Understanding early cognitive changes in Alzheimer's disease
Official title: Characterizing the evolution of Subjective Cognitive Decline in preclinical Alzheimer's disease
Funded at Brigham and Women's Hospital · NIH-10762473 · Data updated 2026-11-12
This study is looking at how people notice changes in their thinking skills, especially in the early stages of Alzheimer's, and it’s for anyone who has concerns about their memory; you'll share your thoughts on your cognitive abilities every few months using a device, and the researchers will compare what you say with medical tests to help find ways to catch dementia early.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | March 1, 2019 |
| Project end | November 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $747,953 |
| NIH project number | 5R01AG058825-05 |
| Project ID | NIH-10762473 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are older adults who have noticed persistent changes in their cognitive functioning.
✕Less likely to help
Patients with advanced Alzheimer's disease or those without any cognitive concerns may not benefit from this research.
What this research studies
This research investigates how individuals perceive changes in their cognitive abilities, known as Subjective Cognitive Decline (SCD), particularly in the early stages of Alzheimer's disease. Participants will be recruited from the community and memory clinics, and they will report their cognitive concerns quarterly using personal electronic devices. The study aims to correlate these subjective reports with objective measures of Alzheimer's disease, such as amyloid and tau levels, to better identify individuals at high risk for developing dementia. By focusing on the patient's perspective, the research seeks to enhance early detection and intervention strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved early detection and prevention strategies for Alzheimer's disease.
How similar studies have gone: Previous research has shown promise in using subjective cognitive reports to identify early cognitive decline, suggesting this approach could be effective.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Amariglio, Rebecca E — Brigham and Women's Hospital
- Study coordinator: Amariglio, Rebecca E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.