Condition

Squamous Cell Carcinoma clinical trials and research

• 36Clinical trials
• 114NIH research projects
• 1New in 30 days
• 13Countries

Newest Squamous Cell Carcinoma clinical trials

All recruiting trials (36)

• Safe use of metformin and naproxen to help prevent cancer in people with Fanconi anemia

  This study tests whether metformin and naproxen can lower the chance of cancer developing in adults with Fanconi anemia.

  Recruiting at 2 sites Phase 1 Rockefeller University · Minneapolis, Minnesota and 1 other locations · NCT07901959

• Two-photon microscopy on skin biopsies to help diagnose skin lesions

  This study tests whether images from two-photon fluorescence microscopy of dermatology biopsies can match the diagnosis determined by standard histology.

  Recruiting University of Rochester · Victor, New York · NCT07773688

• Targeted dual-imaging helper for head and neck cancer surgery

  This study tests whether using two imaging agents during surgery can help doctors see tumors and cancerous lymph nodes in adults with head and neck squamous cell carcinoma.

  Recruiting Phase 1 Vanderbilt-Ingram Cancer Center · Nashville, Tennessee · NCT07741643

• Methionine-Reduced Diet in Solid Tumors (early-phase)

  A small pilot study will test whether a methionine-reduced diet can change blood levels in adults with various solid tumors who are receiving standard cancer therapy.

  Recruiting Early Phase 1 University of California, Irvine · Orange, California · NCT07628634

• IDP-001 in advanced or metastatic solid tumors (including head and neck and skin cancers)

  A first- and second-phase study will test IDP-001 in people with advanced or metastatic solid tumors to see if it is safe and tolerable and to look for signs of activity.

  Recruiting at 6 sites Phase 1/2 InduPro, Inc. · Los Angeles, California and 5 other locations · NCT07602842

• Omitting postoperative radiation after HPV-related oropharyngeal cancer guided by ctHPVDNA monitoring

  This study tests whether some patients with HPV-related OPSCC can skip postoperative radiation after surgery if their tumors are low risk and ctHPVDNA looks negative.

  Recruiting Phase 2 Medical University of South Carolina · Charleston, South Carolina · NCT07513389

• Comprehensive multi-omics and functional profiling to fully characterize tumors

  This project tests whether detailed multi-omics and functional testing of tumor samples can better characterize high-risk blood and solid cancers for patients at participating centers.

  Recruiting at 2 sites Azienda Ospedaliero-Universitaria di Parma · Palermo, Palermo and 1 other locations · NCT07403630

• In-home cancer treatment with remote specialist support for patients in the Florida Panhandle

  This program will try giving standard cancer treatments at home to people living in the Florida Panhandle and nearby areas to see if they prefer it and have better treatment satisfaction.

  Recruiting Phase 2 Mayo Clinic · Jacksonville, Florida · NCT07285044

• Vitamin D and light therapy to boost skin cancer response before surgery

  This study tests whether giving Vitamin D or a placebo around the time of a light-based treatment (PDT) can help boost skin cancer treatment before Mohs surgery or ED&C in adults with basal cell or squamous cell carcinoma.

  Recruiting Case Comprehensive Cancer Center · Cleveland, Ohio · NCT07241585

• Subcutaneous versus intravenous immune therapy: which do patients prefer?

  This project will test whether patients with advanced cancers prefer subcutaneous (under‑the‑skin) versus intravenous nivolumab or, if available, pembrolizumab.

  Recruiting Phase 2 University of Pittsburgh · Pittsburgh, Pennsylvania · NCT07223424

• Induction therapy with toripalimab plus cisplatin and docetaxel for head and neck squamous cell carcinoma

  This study tests whether adding toripalimab to cisplatin and docetaxel induction therapy is safe and tolerable for adults with newly diagnosed locally advanced head and neck squamous cell carcinoma.

  Recruiting at 2 sites Phase 2 Massachusetts General Hospital · Boston, Massachusetts and 1 other locations · NCT07214987

• Neoadjuvant chemoimmunotherapy with PD-1 blockade to reduce surgery for advanced head and neck cancer

  This approach will try a short course of chemotherapy plus the PD-1 drug toripalimab before standard treatment for people with advanced head and neck cancers to shrink tumors and allow less extensive surgery or radiation.

  Recruiting Phase 2 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT07209189

• How TRPV4 in Schwann cells contributes to oral cancer pain

  This project will test whether pressure- and stretch-triggered pain at oral cancer sites differs from the healthy tongue and whether TRPV4 in Schwann cells contributes to that pain.

  Recruiting New York University · New York, New York · NCT07095608

• Anal cancer screening for men on PrEP

  This study will test how well anal swabs and DNA methylation testing find high-grade anal lesions (HSIL) and how common those lesions are in men who have sex with men using PrEP, and whether HSIL affects quality of life.

  Recruiting at 6 sites Universitair Ziekenhuis Brussel · Bruges and 7 other locations · NCT07029152

• Fractional laser plus tirbanibulin ointment for basal and squamous cell skin cancers

  This trial will try combining fractional laser treatment with tirbanibulin ointment to see if it can treat biopsy-confirmed basal cell and squamous cell skin cancers and reduce the need for surgery.

  Recruiting Phase 1/2 Bruce Robinson, MD · New York, New York · NCT07010692

• Long-term clinical and tissue data collection for people with thoracic cancers

  This project will collect medical records, imaging, quality-of-life information, and tissue/blood samples over time from adults with thoracic cancers to try to find factors that predict outcomes.

  Recruiting at 11 sites Dutch Society of Physicians for Pulmonology and Tuberculosis · Ede, Gelderland and 22 other locations · NCT06996249

• Toripalimab plus carboplatin and docetaxel before surgery for sinonasal cancer

  This study tests whether giving toripalimab with carboplatin and docetaxel before surgery helps people with locally advanced sinonasal cancers.

  Recruiting at 2 sites Phase 2 Dana-Farber Cancer Institute · Boston, Massachusetts and 1 other locations · NCT06940180

• Using special imaging to reduce throat surgery complications

  This study tests if using special imaging during throat surgery can help reduce complications, like infections, for patients with throat cancer.

  Recruiting Phase 2 University of Pittsburgh · Pittsburgh, Pennsylvania · NCT06831149

• Electrochemotherapy for unresectable visceral tumors including liver metastases

  This will try electrochemotherapy with bleomycin in adults who have unresectable primary or metastatic visceral tumors, such as liver metastases.

  Recruiting Istituto Oncologico Veneto IRCCS · Padova · NCT06753136

• Lidocaine injection before surgery for oropharyngeal cancer

  This study tests if giving a lidocaine injection before surgery can help improve outcomes for patients with oropharyngeal cancer.

  Recruiting Phase 1 Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT06747390

• Gene therapy to reduce skin cancer recurrence in patients with a specific genetic condition

  This study is testing a new gene therapy to see if it can help people with a specific skin condition reduce the chances of skin cancer coming back after treatment.

  Recruiting at 2 sites Phase 2 Stanford University · Redwood City, California and 1 other locations · NCT06731933

• Alpha DaRT treatment for skin squamous cell cancer in immunocompromised patients

  This study tests whether placing Alpha DaRT seeds directly into a skin squamous cell carcinoma can shrink tumors and improve outcomes in people with compromised immune systems.

  Recruiting at 6 sites Alpha Tau Medical LTD. · Gilbert, Arizona and 10 other locations · NCT06615635

• Treatment of advanced solid tumors with VET3-TGI immunotherapy

  This study is testing a new cancer treatment called VET3-TGI to see if it can safely target and kill cancer cells in patients with advanced solid tumors, either by injecting it directly into the tumors or giving it through an IV.

  Recruiting at 7 sites Phase 1 KaliVir Immunotherapeutics · Los Angeles, California and 6 other locations · NCT06444815

• Using Raman Spectroscopy to assess skin cancer tumors

  This study is testing a new imaging technique to see if it can help doctors better understand the size and spread of skin cancer tumors in patients with basal cell and squamous cell carcinoma.

  Recruiting Stony Brook University · Stony Brook, New York · NCT06384924

• Treatment for advanced lung squamous cell carcinoma using BAI-BACE

  This study is testing a new treatment for advanced lung cancer that directly delivers chemotherapy to the tumor to see if it helps patients who haven't responded to other therapies.

  Recruiting Sun Yat-sen University · Beijing, Beijing Municipality · NCT06377735

• Personalized radiation therapy for head and neck cancer

  This study is testing whether using MRI to tailor radiation therapy can improve treatment for people with head and neck cancer.

  Recruiting Phase 2 H. Lee Moffitt Cancer Center and Research Institute · Tampa, Florida · NCT06137274

• Testing NEO212 for treating certain brain tumors and metastases

  This study is testing a new treatment called NEO212 for people with certain types of brain tumors to see if it is safe and effective when combined with standard treatments.

  Recruiting at 8 sites Phase 1/2 Neonc Technologies, Inc. · Beverly Hills, California and 7 other locations · NCT06047379

• Testing a new antibody treatment for advanced squamous cell cancers

  This study is testing a new antibody treatment combined with chemotherapy for people with advanced squamous cell cancers that haven't responded to standard therapies.

  Recruiting at 17 sites Phase 1/2 Hummingbird Bioscience · Sydney, New South Wales and 19 other locations · NCT05910827

• Understanding survival and factors affecting squamous cell carcinoma of the nasal vestibule

  This study looks at how well people with squamous cell carcinoma of the nasal vestibule do after surgery and what factors might affect their survival.

  Recruiting at 6 sites Istituto Clinico Humanitas · Toulouse, Touluse and 5 other locations · NCT05693116

• Using sentinel lymph node biopsy to assess cutaneous squamous cell carcinoma in the head and neck

  This study is testing if a special biopsy can help find hidden tumors in patients with a certain type of skin cancer in the head and neck to see if they need more intense treatment.

  Recruiting Indiana University · Indianapolis, Indiana · NCT05108090

• Spectroscopic analysis of tongue cancer tissue during surgery

  Researchers will use a real-time spectroscopic tool during tongue cancer surgery to see if tissue looks cancerous or not, helping guide removal in patients with squamous cell carcinoma of the tongue.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens, Picardie · NCT05104619

• Combination of immunotherapy and chemotherapy for advanced nasal cavity cancer

  This study is testing a new treatment that combines immunotherapy with chemotherapy to see if it can help people with advanced nasal cavity cancer respond better and live longer.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT05027633

• Early diagnosis of upper digestive tract diseases using breath tests

  This study is testing a breath test to see if it can help find upper digestive tract cancers earlier in patients who are already getting checked for digestive issues.

  Recruiting Imperial College London · London · NCT04475952

• Treatment of advanced solid tumors with T3011 and pembrolizumab

  This study is testing a new treatment called T3011, given as an injection, alone and with another drug called pembrolizumab, to see if it helps people with advanced solid tumors like melanoma and head and neck cancer.

  Recruiting at 8 sites Phase 1/2 ImmVira Pharma Co. Ltd · Gilbert, Arizona and 8 other locations · NCT04370587

• T Cell Receptor Immunotherapy for Metastatic Non-Small Cell Lung Cancer

  This study is testing a new treatment for advanced lung cancer that uses special immune cells from patients' own tumors to see if it can help shrink their cancer.

  Recruiting Phase 2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT02133196

• Comparing chemotherapy combinations for advanced head and neck cancer

  This study is testing two different chemotherapy combinations to see which one works better for people with advanced head and neck cancer while they also receive radiation therapy.

  Recruiting Phase 2 University of Pittsburgh · Pittsburgh, Pennsylvania · NCT02128906

NIH-funded research (newest 40 of 114)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Novel idea: Epstein-Barr virus and eye cancer in people living with HIV in Zimbabwe

  A study explores whether Epstein-Barr virus could cause a type of eye cancer in people living with HIV in Zimbabwe.

  NIH research H. Lee Moffitt Cancer Ctr & Res Inst · Tampa, United States · NIH-11625534

• Oral cancer recurrence predictor using tumor microbes and gene activity

  This NIH grant explores how bacteria and immune signals inside oral cancer tumors relate to whether the cancer comes back, with the aim of making a practical risk predictor for patients.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11591548

• Data-driven classification of aggressive tissue traits to predict cancer outcomes in HPV-negative head and neck cancer

  A clinician-science grant uses data science and AI to identify tissue patterns in HPV-negative head and neck cancer that may predict how long patients stay cancer-free.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11505841

• Targeting PIPKIγi5 to boost immune responses against head and neck cancer

  A study to see if blocking a specific enzyme, PIPKIγi5, can make head and neck cancer more visible to the immune system and more responsive to existing immunotherapies.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-11449300

• Targeted approaches for lung squamous cell carcinoma with key gene changes

  A study at a major university is exploring new targets in lung squamous cell carcinoma to help people with this cancer find better treatments.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11449092

• Baculovirus-based therapy to treat head and neck cancer with a gentle, minimally invasive approach

  A new, minimally invasive approach using baculovirus-delivered CRISPR gene editing aims to treat head and neck squamous cell carcinoma while aiming to preserve essential tissues.

  NIH research University of Kentucky · Lexington, United States · NIH-11445557

• Reducing bacteria inside oral cancer tumors to boost immune response

  In people with head and neck cancer, this study tests whether lowering bacteria in tumors can help the immune system fight the cancer better.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11439220

• Novel look at EBV as a possible cause of eye cancer in people with HIV in Zimbabwe

  A study will explore whether Epstein-Barr virus may contribute to an eye cancer (cSCC) in people living with HIV in Zimbabwe.

  NIH research H. Lee Moffitt Cancer Ctr & Res Inst · Tampa, United States · NIH-11418498

• Does Epstein-Barr virus cause conjunctival (eye) cancer in people with HIV in Zimbabwe?

  This project looks for a link between the Epstein-Barr virus and conjunctival squamous cell carcinoma in people living with HIV in Zimbabwe.

  NIH research H. Lee Moffitt Cancer Ctr & Res Inst · Tampa, United States · NIH-11414781

• Hypoxia and metabolism as targets to improve immunotherapy in head and neck cancer

  This grant tests new combinations of metabolic drugs with immunotherapy to help people with head and neck cancer respond better to treatment.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11404946

• CD1530: A promising oral cavity cancer prevention approach using a RAR gamma activator

  A researcher is testing a drug that activates a receptor in the lining of the mouth to help prevent squamous cell cancers before they start or spread.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11403870

• Postoperative ctDNA in Drain Fluid to Detect Remaining Cancer in Head and Neck Cancer

  A patient-friendly test using fluid from surgical drains after head and neck cancer surgery may reveal tiny remaining cancer cells sooner.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11402625

• Genomic map of cutaneous squamous cell carcinoma and its earliest genetic changes

  This project looks at the genes involved in a common skin cancer (cutaneous squamous cell carcinoma) to understand what mutations drive its growth and how it evolves from benign skin lesions.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11398277

• Chromosome 3 Aneuploidy in Squamous Cell Carcinoma and its Impact on Key Cancer Pathways

  This grant studies how losing or gaining parts of chromosome 3 drives squamous cell cancers and alters important cell signaling and growth pathways.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11398272

• MiR-27a* as a new therapy approach for head and neck cancer

  Aims to use a small RNA, miR-27a*, to hit several cancer pathways at once in head and neck squamous cell carcinoma to help fight the disease.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11381876

• Splice-variant neoantigens as a vaccine target for head and neck cancer

  A patient-focused approach to identifying unique tumor antigens from abnormal RNA splicing in head and neck cancer and testing a vaccine to help the immune system recognize and fight the cancer.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11380029

• Biomarkers and AI insights to understand OSCC racial survival gaps

  A patient-facing look at using AI to understand why oral cavity squamous cell carcinoma affects African ancestry patients differently and what biomarkers and imaging can reveal.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-11375147

• Racial differences in how head and neck cancer develops at the molecular level

  This NIH grant explores how genetic and immune factors may drive head and neck cancer to grow and spread, with a focus on racial differences.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11373510

• REASON Score: an epigenetic and clinicopathologic approach to predict survival risk in early oral cancer

  A new biomarker-based score using DNA methylation and clinicopathology to predict survival risk for people with early-stage oral squamous cell carcinoma.

  NIH research Loma Linda University · Loma Linda, UNITED STATES · NIH-11372175

• New vulnerability in oral cancer linked to p53 loss

  A cancer research grant is exploring a surprising weakness in head and neck cancer to help people with HPV-negative oral squamous cell carcinoma.

  NIH research Thomas Jefferson University · Philadelphia, United States · NIH-11370165

• Biomarker test to predict immunotherapy response in head and neck cancer

  A multi-site study aims to validate blood-based and immune biomarkers to predict which head and neck cancer patients will respond to immunotherapy.

  NIH research Dartmouth College · Hanover, United States · NIH-11342927

• CCR2 PET imaging in head and neck cancer

  A new PET imaging approach uses a CCR2-targeted tracer to visualize cancer and immune cells in head and neck squamous cell carcinoma (HNSCC) to help guide treatment.

  NIH research Washington University · Saint Louis, United States · NIH-11342138

• Mouth bacteria that may speed up oral cancer

  This work looks at whether specific mouth bacteria help oral squamous cell carcinoma grow and spread in people who have or are at risk for oral cancer.

  NIH research Oklahoma State University Stillwater · Stillwater, United States · NIH-11335589

• Stromal cells and head-and-neck cancer: uncovering how supporting cells drive tumor growth

  Aims to understand how special stromal cells in head and neck cancer interact with tumor cells to influence progression, using advanced 3D models and single-cell data to inform future therapies.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11332553

• Skin electrical scanning to tell if a spot is basal or squamous cell skin cancer

  This project uses a handheld skin electrical scanner with smart computer analysis to help doctors tell whether common skin spots are harmless, precancerous, or invasive basal or squamous cell cancers.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11328116

• Targeting a stress-specific function of a DNA replication protein to boost oral cancer therapy

  A short, targeted NIH grant explores a new way to make existing treatments work better for oral cancer by attacking a special function of a DNA replication protein that cancer cells rely on.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11321521

• Imaging immune cells (macrophages) inside head and neck cancer with fluorine-19 MRI

  This project will use a special fluorine-19 MRI scan after an injected tracer to show macrophage immune cells in tumors of people with recurrent head and neck cancer.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11319716

• Dermal therapy to treat skin squamous cell carcinoma

  A new topical treatment is being developed for people with skin squamous cell carcinoma, especially when surgery isn’t an option.

  NIH research Via Therapeutics, LLC · Austin, United States · NIH-11316113

• AI-powered miRNA test to tell oral cancer from benign leukoplakia without surgery

  A noninvasive brush-based test using artificial intelligence analyzes tiny RNA patterns to distinguish oral cancer from benign oral lesions, helping people avoid delays.

  NIH research Arphion, LTD · Chicago, United States · NIH-11314925

• Stopping early lung squamous changes before they become cancer

  Researchers are building better lab models that mirror early lung squamous changes to help find medicines that stop premalignant lesions from becoming cancer in people at risk.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11310165

• NRF2 gene activity and squamous cell lung cancer

  This project will find out how changes in a gene called NRF2 affect the start and treatment resistance of lung squamous cell carcinoma in people.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11306569

• Immune clues for preventing oral cancer from early lesions

  A doctor-scientist team will look at how the immune system behaves in early mouth lesions to predict which ones become cancer and how to intervene earlier.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11301814

• Personalized vaccine plus anti-PD-1 for recurrent or metastatic head and neck cancer

  A personalized vaccine made from each patient's tumor is combined with anti‑PD‑1 immunotherapy for adults with recurrent or metastatic head and neck cancer.

  NIH research Emory University · Atlanta, United States · NIH-11300175

• Investigating how tissue damage leads to a specific type of skin cancer.

  This study is looking at how skin cancer develops in people with a rare genetic condition called Recessive Dystrophic Epidermolysis Bullosa (RDEB), to find out what causes it and how to improve treatment options for those affected.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11293811

• Targeting HER3 and EGFR pathways in head and neck cancer

  A Yale-led project aims to find better ways to treat head and neck cancer by using targeted antibodies and antibody-drug conjugates to block EGFR and HER3 signaling.

  NIH research Yale University · New Haven, United States · NIH-11265317

• Targeted immune-boosting therapy for head and neck cancer

  This work uses a tumor-targeted drug that turns on a cancer-cell immune alarm called STING to help radiation and chemotherapy work better for people with head and neck cancer.

  NIH research Yale University · New Haven, United States · NIH-11252352

• Blocking NRF2 to help radiation work better for head and neck cancer

  Trying drugs that block a protein called NRF2 to help radiation therapy work better for people with head and neck squamous cell carcinoma.

  NIH research Washington University · Saint Louis, United States · NIH-11249676

• Engineered CAR-T cells targeting CSPG4 for head and neck cancer

  This trial gives engineered immune cells (CAR‑T) that target a protein called CSPG4 to adults with head and neck squamous cell carcinoma that has not responded to platinum chemotherapy and PD‑1 therapy.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11235163

• Antibody-microRNA therapy for head and neck cancer

  A new medicine links the anti‑EGFR antibody cetuximab to a microRNA mimic to treat people with advanced head and neck squamous cell carcinoma.

  NIH research Mirecule, INC. · Gaithersburg, UNITED STATES · NIH-11194434

• Targeting low oxygen and abnormal metabolism to help immunotherapy work better in head and neck cancer

  This research tests whether changing tumor oxygen levels and metabolism can help immunotherapy work better for people with recurrent or metastatic head and neck cancer.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11192275

Related topics

Quick answers

How many Squamous Cell Carcinoma clinical trials are recruiting right now?

36, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 13 countries. The most sites are in United States (27 trials), Italy (4 trials), France (2 trials), Australia (2 trials), United Kingdom (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 12, Phase 1/2: 5, Phase 1: 4, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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