Condition

Head and Neck Squamous Cell Carcinoma clinical trials and research

• 125Clinical trials
• 1New in 30 days
• 25Countries

Newest Head and Neck Squamous Cell Carcinoma clinical trials

All recruiting trials (125)

• Neoadjuvant therapy with nimotuzumab, toripalimab, nab-paclitaxel, and cisplatin for locally advanced head and neck cancer

  This study tests a pre-surgery treatment combining targeted therapy, immunotherapy, and chemotherapy to see if it helps patients with locally advanced, resectable head and neck squamous cell carcinoma.

  Recruiting Phase 2 Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Hebei, Hebei · NCT07906587

• ICG with near-infrared imaging to visualize head and neck cancer during surgery

  This study tests whether first-window indocyanine green fluorescence seen during surgery matches the cancer extent seen on pathology in patients with head and neck squamous cell carcinoma.

  Recruiting Phase 2 Washington University School of Medicine · St Louis, Missouri · NCT07825597

• ABBV-253 in adults with advanced solid tumors

  This study tests ABBV-253 to see if it is safe, how it affects the cancer, and how the drug moves in the body for adults with advanced solid tumors.

  Recruiting at 3 sites Phase 1 AbbVie · Grand Rapids, Michigan and 2 other locations · NCT07807956

• Online Sharing for Head & Neck Cancer Support

  A mobile app designed for adults with head and neck cancer undergoing radiotherapy to see if daily social sharing and peer interaction can help reduce psychological distress.

  Recruiting West China Hospital · Chengdu, Sichuan · NCT07766226

• Telisotuzumab Adizutecan with Pembrolizumab as first-line treatment for recurrent or metastatic head and neck cancer

  This study tests a combination treatment to see if it helps people with newly diagnosed recurrent or metastatic head and neck squamous cell carcinoma who express the c-Met protein.

  Recruiting at 5 sites Phase 2 AbbVie · Duarte, California and 4 other locations · NCT07744126

• Mild heat therapy added to standard treatment for locally advanced head and neck cancer

  This early-stage trial tests whether mild hyperthermia can be safely added to standard radiotherapy with or without chemotherapy for locally advanced head and neck cancer.

  Recruiting Phase 1 Erasmus Medical Center · Rotterdam, South Holland · NCT07690618

• Docetaxel and SX-682 in head and neck cancers and prostate cancer

  This trial tests a new drug SX-682 together with docetaxel in adults whose head and neck cancers or prostate cancer have returned or spread.

  Recruiting Phase 1/2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT07667400

• CCR2 PET Imaging for Head and Neck Squamous Cell Carcinoma

  This trial tests whether Cu-64 DOTA-ECL1i PET/CT can reliably detect HNSCC in adults, including those with new locally advanced disease or suspected/confirmed recurrent/metastatic cancer.

  Recruiting Phase 2 Washington University School of Medicine · St Louis, Missouri · NCT07659678

• First-in-human test of HH160 in people with advanced solid tumors

  HH160 is being tested to see if it is safe and how it behaves in the body, to see if it has early signs of helping various advanced cancers in adults.

  Recruiting at 3 sites Phase 1 Huahui Health · Waratah, New South Wales and 2 other locations · NCT07623369

• IDP-001 in advanced or metastatic solid tumors (including head and neck and skin cancers)

  A first- and second-phase study will test IDP-001 in people with advanced or metastatic solid tumors to see if it is safe and tolerable and to look for signs of activity.

  Recruiting at 6 sites Phase 1/2 InduPro, Inc. · Los Angeles, California and 5 other locations · NCT07602842

• Nimotuzumab plus Immunotherapy and Chemotherapy before surgery for locally advanced head and neck cancer

  This phase 2 trial tests whether adding nimotuzumab to immunotherapy and chemotherapy before surgery helps people with locally advanced head and neck squamous cell carcinoma.

  Recruiting Phase 2 Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine · Shanghai · NCT07601737

• IBI3028 in advanced solid tumors

  This phase 1 study tests IBI3028 in adults with unresectable or metastatic solid tumors to see if it is safe and how patients tolerate it.

  Recruiting Phase 1 Innovent Biopharmaceutical Technology (Hangzhou) Co., LTD. · Tianjin, Tianjin Municipality · NCT07589205

• Pucotenlimab plus Becotatug Vedotin in locally advanced resectable head and neck cancer

  This study tests whether giving Pucotenlimab with Becotatug Vedotin around surgery helps patients with resectable head and neck squamous cell carcinoma.

  Recruiting Phase 2 Lepu Biopharma Co., Ltd. · Beijing, Beijing Municipality and 14 other locations · NCT07586124

• Pre-surgery immune checkpoint therapy plus mitochondrial vaccine for operable head and neck cancer

  This trial will try a mitochondrial vaccine together with immune checkpoint drugs before and after surgery to see if it helps people with IMP3-positive, operable locally advanced head and neck cancer.

  Recruiting Phase 2 West China Hospital · Chengdu, Sichuan and 1 other locations · NCT07572864

• CFH protein delivered by ice microneedles to prevent radiation-related skin fibrosis

  This phase 1 test gives CFH protein with ice microneedle patches to people with head and neck squamous cell carcinoma getting postoperative radiotherapy to see if it is safe and may prevent radiation-related skin fibrosis.

  Recruiting Phase 1 West China Hospital · Chengdu, Sichuan · NCT07567235

• Galenos 2: Immunonutrition for head and neck, lung, and rectal cancer patients

  This trial tests whether taking a twice-daily galenic immunonutrition supplement can reduce side effects and help people with head and neck, lung, or locally advanced rectal cancer complete their cancer therapy.

  Recruiting Fondazione del Piemonte per l'Oncologia · Candiolo, Torino (TO) · NCT07514754

• GALENOS 1: Longitudinal nutrition and body composition in head and neck, lung, and rectal cancer patients

  This project will see how nutritional status and body composition change over time in adults with head and neck, lung, or locally advanced rectal cancer who are receiving standard anticancer treatments.

  Recruiting Fondazione del Piemonte per l'Oncologia · Candiolo, Torino (TO) · NCT07511413

• IDE034 for adults with advanced solid tumors that express B7-H3 and PTK7

  This trial will test IDE034 to see if it is safe and works in adults with advanced or metastatic solid tumors that express B7-H3 and PTK7.

  Recruiting at 26 sites Phase 1 IDEAYA Biosciences · Duarte, California and 25 other locations · NCT07503808

• EPI-326 for EGFR-mutant non-small cell lung cancer and head and neck squamous cell carcinoma

  This phase 1 trial will try EPI-326, a new drug, in people with EGFR-mutant non‑small cell lung cancer or advanced head and neck squamous cell carcinoma to find safe doses, study how the body handles it, and look for early signs it shrinks tumors.

  Recruiting at 8 sites Phase 1 EpiBiologics · Los Angeles, California and 7 other locations · NCT07462377

• Selective dose reduction of neck radiation in HPV-associated oropharyngeal cancer

  This trial tests whether lowering radiation doses to certain neck lymph nodes or gross disease areas is safe and can reduce side effects for adults with HPV-related oropharyngeal cancer.

  Recruiting at 4 sites Phase 2 University of Maryland, Baltimore · Baltimore, Maryland and 3 other locations · NCT07418034

• H101 Plus TACE for advanced head and neck cancer

  This study tests whether adding H101 to transarterial chemoembolization can help treat recurrent or metastatic head and neck squamous cell carcinoma.

  Recruiting Phase 2 West China Hospital · Chengdu, Sichuan · NCT07398664

• Becotatug Vedotin with or without Immunotherapy before surgery for locally advanced head and neck cancer

  This trial tests Becotatug Vedotin alone or together with immune checkpoint inhibitors to see if pre-surgery treatment can improve outcomes for people with resectable locally advanced head and neck squamous cell carcinoma.

  Recruiting Phase 2 West China Hospital · Chengdu, Sichuan · NCT07381075

• Testing SIM0610 for adults with advanced solid tumors

  This will test whether SIM0610 is safe and can shrink tumors in adults with locally advanced or metastatic solid cancers such as non-small cell lung, colorectal, liver, and head and neck cancers.

  Recruiting Phase 1 Jiangsu Simcere Pharmaceutical Co., Ltd. · Chongqing, Chongqing Municipality and 6 other locations · NCT07348211

• Lutetium [177Lu]-BL-ARC001 for advanced lung, breast, head and neck and other solid tumors

  This study will test a radiolabeled drug called Lutetium [177Lu]-BL-ARC001 in adults with advanced or metastatic solid tumors (such as lung, breast, or head and neck cancers) whose standard treatments have not worked.

  Recruiting Phase 1 Sichuan Baili Pharmaceutical Co., Ltd. · Chengdu, Sichuan · NCT07274852

• SYS6010 combined with Enlonstobart for recurrent or metastatic head and neck squamous cell carcinoma

  This trial will test whether giving SYS6010 together with Enlonstobart can help people aged 18–75 who have recurrent or metastatic head and neck squamous cell carcinoma and are not candidates for surgery or chemoradiotherapy.

  Recruiting Phase 2 CSPC Megalith Biopharmaceutical Co.,Ltd. · Shanghai, Shanghai Municipality · NCT07254585

• BL-M24D1 for advanced head and neck and other solid tumors

  This study will try BL-M24D1 in adults with locally advanced or metastatic head and neck squamous cell carcinoma or other solid tumors to see if it is safe and shows early signs of benefit.

  Recruiting Phase 1 Sichuan Baili Pharmaceutical Co., Ltd. · Chengdu, Sichuan · NCT07232524

• Using [18F]NOTA-ABY030 PET/CT to clarify indeterminate head and neck squamous cell carcinoma lesions

  This trial will test whether the new PET imaging agent [18F]NOTA-ABY030 is safe and can better detect unclear primary or metastatic lesions in adults with head and neck squamous cell carcinoma.

  Recruiting Phase 1 Vanderbilt-Ingram Cancer Center · Nashville, Tennessee · NCT07217028

• FT836 alone or with chemotherapy and antibody drugs for advanced solid tumors.

  This trial will test if FT836, given alone or with paclitaxel and/or the antibodies trastuzumab or cetuximab, is safe and tolerable for people with advanced solid tumors who have already received prior treatment.

  Recruiting at 5 sites Phase 1 Fate Therapeutics · La Jolla, California and 4 other locations · NCT07216105

• CUE-101 with pembrolizumab for locally advanced HPV‑16 positive oropharyngeal cancer

  This trial tests whether CUE-101 alone or combined with pembrolizumab before definitive therapy helps people with newly diagnosed, locally advanced HPV‑16 positive oropharyngeal cancer who are HLA‑A*02:01 positive.

  Recruiting Phase 2 Yale University · New Haven, Connecticut · NCT07172256

• Testing AZD6750 safety in adults with selected advanced or metastatic solid tumors

  This trial tests whether AZD6750, a CD8-guided IL-2 medicine given alone or with other cancer drugs, is safe and how it behaves in adults with certain advanced or metastatic solid tumors.

  Recruiting at 13 sites Phase 1/2 AstraZeneca · Grand Rapids, Michigan and 12 other locations · NCT07115043

• TER-2013 for advanced solid tumors with AKT/PI3K/PTEN pathway changes

  This trial tests whether TER-2013, alone or with fulvestrant, is safe and can help people with advanced breast, ovarian, endometrial, lung, or head-and-neck cancers that have AKT/PI3K/PTEN pathway alterations.

  Recruiting at 20 sites Phase 1/2 Terremoto Biosciences Inc. · Duarte, California and 24 other locations · NCT07109726

• Nimotuzumab plus Adebrelimab with chemotherapy for cisplatin‑ineligible head and neck cancer

  This trial will try combining nimotuzumab and adebrelimab with chemotherapy to see if the regimen is safe and helps people with recurrent or metastatic head and neck squamous cell carcinoma who cannot receive high‑dose cisplatin.

  Recruiting Phase 1/2 Fudan University · Shanghai, Shanghai Municipality · NCT07105592

• Personalized compartment-sparing postoperative radiation for head and neck cancer

  This trial tests whether targeted, compartment-sparing postoperative radiation can reduce side effects while keeping cancer control for people with surgically treated head and neck squamous cell carcinoma.

  Recruiting at 3 sites Phase 2 Insel Gruppe AG, University Hospital Bern · Basel and 2 other locations · NCT07058805

• DR-0202 for advanced, relapsed, or treatment-resistant carcinomas

  This trial tests DR-0202 in adults with advanced or metastatic carcinomas—such as certain breast, lung, cervical, and prostate cancers—that have relapsed or stopped responding to standard treatments.

  Recruiting at 10 sites Phase 1 Dren Bio · Denver, Colorado and 9 other locations · NCT06999187

• Olanzapine to prevent appetite loss during chemoradiation for head and neck cancer

  This trial tests whether adding olanzapine to usual symptom care can help prevent appetite loss and weight loss in adults receiving chemoradiation for head and neck cancer.

  Recruiting Phase 2 Roswell Park Cancer Institute · Buffalo, New York · NCT06995508

• High-dose gabapentin versus placebo to prevent opioid use for mouth pain during chemoradiation for head and neck cancer

  This will test whether taking high-dose gabapentin during cisplatin chemoradiation for head and neck cancer helps people avoid needing opioid pain medicine for painful mouth sores.

  Recruiting at 191 sites Phase 3 Alliance for Clinical Trials in Oncology · Gilbert, Arizona and 215 other locations · NCT06992427

• Cemiplimab with or without CDX-1140 given before surgery for stage III-IV head and neck cancer

  This trial tests whether adding the immune stimulant CDX-1140 to cemiplimab before surgery helps shrink tumors in people with resectable stage III-IV head and neck squamous cell carcinoma.

  Recruiting at 12 sites Phase 2 National Cancer Institute (NCI) · Irvine, California and 11 other locations · NCT06980038

• Comparing two imaging techniques for assessing blood vessel effects in head and neck cancer patients receiving radiation therapy

  This study is testing if a new type of imaging can better spot blood vessel problems in head and neck cancer patients getting radiation therapy compared to the usual imaging method.

  Recruiting Early Phase 1 Emory University · Atlanta, Georgia · NCT06914999

• Biomarker analysis for patients with advanced head and neck cancer

  This study is testing if certain biomarkers in biopsy samples can help predict how well patients with advanced head and neck cancer will respond to their treatment.

  Recruiting National Cancer Institute, Naples · Naples · NCT06905145

• Treatment for adult patients with solid tumors that have a specific p53 mutation

  This study is testing a new treatment for adults with advanced solid tumors that have a specific p53 mutation to see if it is safe and effective.

  Recruiting at 21 sites Phase 1 Clasp Therapeutics, Inc. · Scottsdale, Arizona and 20 other locations · NCT06778863

• Investigating ALE.P02 for treating specific solid tumors in adults

  This study is testing a new treatment called ALE.P02 to see if it can safely help adults with advanced solid tumors that have a specific marker called Claudin-1.

  Recruiting at 39 sites Phase 1/2 Alentis Therapeutics AG · Scottsdale, Arizona and 40 other locations · NCT06747585

• Assessing cervical lymph nodes response in head and neck cancer after treatment

  This study is testing if a special ultrasound can help doctors see how well treatment is working on lymph nodes in patients with head and neck cancer.

  Recruiting Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Guangzhou, Guangdong · NCT06727162

• Combining chemotherapy, radiotherapy, and immunotherapy for advanced head and neck cancer

  This study is testing a new treatment that combines chemotherapy, radiation, and immunotherapy for patients with advanced head and neck cancer who can't have surgery to see if it helps them live longer and feel better.

  Recruiting Phase 2 Beijing Tongren Hospital · Beijing, Beijing Municipality · NCT06725498

• Tiny, direct injections of PBA-0111 into solid tumors to see local immune and tumor responses

  This study will try tiny, localized injections of PBA-0111 into tumors of adults with head and neck cancer, selected soft-tissue sarcomas, or triple-negative breast cancer to see if it triggers immune activity and tumor cell killing in the tumor microenvironment.

  Recruiting Early Phase 1 Pure Biologics S.A. · Shreveport, Louisiana · NCT06700070

• Evaluating the effects of AHCC in HPV-positive head and neck cancer patients

  This study is testing whether AHCC capsules are safe and well-tolerated for adults with HPV-positive head and neck cancer who are undergoing surgery.

  Recruiting Phase 2 University of California, Irvine · Orange, California · NCT06693323

• Patient-derived organoid drug sensitivity testing for recurrent/metastatic head and neck cancer

  This project will test whether drug-sensitivity results from a patient's tumor-derived organoids predict which systemic treatments work best for people with recurrent or metastatic head and neck cancer.

  Recruiting Huashan Hospital · Shanghai, Shanghai Municipality and 1 other locations · NCT06686342

• Remote hearing tests for patients with head and neck cancer receiving chemotherapy or radiation

  This study is testing if remote hearing tests can help patients with advanced head and neck cancer keep track of their hearing loss during chemotherapy or radiation, making it easier for those who live far away to participate.

  Recruiting Emory University · Atlanta, Georgia · NCT06662058

• Adding superficial heat therapy (wIRA) to standard palliative radiotherapy

  This project will test whether adding superficial hyperthermia (wIRA) to standard palliative radiotherapy helps control superficial tumours in adults with inoperable or recurrent head and neck, cutaneous, or recurrent breast cancers.

  Recruiting at 2 sites King's College London · London and 1 other locations · NCT06659146

• Using Afatinib to treat patients with Fanconi Anemia and advanced head and neck cancer

  This study is testing if Afatinib can help people with advanced head and neck cancer who also have Fanconi Anemia feel better and improve their condition.

  Recruiting at 2 sites Phase 1/2 Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau · Hanover and 1 other locations · NCT06648096

• Imaging study using two antibody fragments in patients with solid tumors

  This study is testing two special antibody fragments in people with solid tumors to see how well they target cancer cells and how they move through the body.

  Recruiting Early Phase 1 Var2 Pharmaceuticals · Groningen, Provincie Groningen · NCT06645808

• Comparing AK112 and AK117 to Pembrolizumab for Head and Neck Cancer

  This study is testing if a new combination treatment of AK112 and AK117 can work better than the standard drug pembrolizumab for people with advanced head and neck cancer.

  Recruiting at 2 sites Phase 3 Akeso · Wuhan, Hubei and 1 other locations · NCT06601335

• Combining ACR-368 and low dose gemcitabine for treating advanced head and neck cancer

  This study is testing if combining ACR-368 with a low dose of gemcitabine can help people with advanced head and neck cancer feel better and live longer.

  Recruiting Phase 2 H. Lee Moffitt Cancer Center and Research Institute · Tampa, Florida · NCT06597565

• Effects of neoadjuvant therapy on pain, anxiety, and depression in head and neck cancer patients

  This study is testing how a combination of chemotherapy and immunotherapy affects pain, anxiety, and depression in patients with head and neck cancer who are preparing for surgery.

  Recruiting Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Guanzhou, Guangdong · NCT06575322

• Enhanced MRI for detecting lymph node metastasis in head and neck cancer

  This study is testing a new MRI contrast agent to see if it can help doctors better detect cancer spread in lymph nodes for people with head and neck cancer.

  Recruiting Phase 1 MegaPro Biomedical Co. Ltd. · Taipei · NCT06540443

• Adding BMX-001, a drug that protects normal tissue from radiation damage, to standard chemoradiation for head and neck cancer

  This trial tests whether giving BMX-001 along with usual mouth-care reduces severe mouth sores in people getting cisplatin-based chemoradiation for HPV-related and other head and neck cancers.

  Recruiting at 146 sites Phase 2 NRG Oncology · Gilbert, Arizona and 152 other locations · NCT06532279

• Combining cadonilimab with low-dose radiation for advanced head and neck cancer

  This study is testing if combining a new antibody treatment with low-dose radiation can help people with advanced head and neck cancer who haven't responded to previous treatments.

  Recruiting Phase 2 Fudan University · Shanghai, Shanghai Municipality · NCT06494995

• Combining immune therapy and chemotherapy for advanced head and neck cancer

  This study is testing if combining two immune therapies with chemotherapy can help people with advanced head and neck cancer have better treatment results before surgery.

  Recruiting Phase 1/2 Fudan University · Shanghai, Shanghai Municipality · NCT06494943

• LY4052031 for advanced or metastatic urothelial and other nectin‑4–expressing solid tumors

  This trial will test whether LY4052031 is safe and can help people with advanced or metastatic urothelial cancer or other solid tumors that express nectin‑4.

  Recruiting at 36 sites Phase 1 Eli Lilly and Company · Duarte, California and 39 other locations · NCT06465069

• Testing ZM008 alone and with Pembrolizumab in patients with advanced solid tumors

  This study is testing a new treatment called ZM008, alone and with another drug called Pembrolizumab, to see if it can help patients with advanced solid tumors who have run out of other treatment options.

  Recruiting at 3 sites Phase 1 Zumutor Biologics Inc. · Boston, Massachusetts and 2 other locations · NCT06451497

• Treatment of advanced solid tumors with VET3-TGI immunotherapy

  This study is testing a new cancer treatment called VET3-TGI to see if it can safely target and kill cancer cells in patients with advanced solid tumors, either by injecting it directly into the tumors or giving it through an IV.

  Recruiting at 7 sites Phase 1 KaliVir Immunotherapeutics · Los Angeles, California and 6 other locations · NCT06444815

• Neoadjuvant immunotherapy combined with chemotherapy for advanced head and neck cancer

  This study is testing whether combining three different immunotherapy drugs with chemotherapy can help people with advanced head and neck cancer before surgery.

  Recruiting Phase 2 West China Hospital · Chengdu, Sichuan · NCT06444009

• Combination therapy for recurrent or metastatic head and neck cancer

  This study is testing a new combination treatment for adults with recurrent or metastatic head and neck cancer to see if it helps them better than current options.

  Recruiting Phase 2 Sichuan Baili Pharmaceutical Co., Ltd. · Shanghai, Shanghai Municipality · NCT06437522

• Reducing dosing frequency of immune checkpoint inhibitors in advanced cancers

  This study is testing if giving immune checkpoint inhibitors less often can still help people with advanced cancers feel better while making treatment easier and cheaper.

  Recruiting Phase 2 National University Hospital, Singapore · Singapore · NCT06422403

• Combining Tislelizumab with chemotherapy before surgery for head and neck cancer

  This study is testing if giving Tislelizumab with chemotherapy before surgery helps people with head and neck cancer do better than just having surgery right away.

  Recruiting Phase 2 Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Guangzhou, Yuexiu · NCT06323369

• Personalized treatment intensification for head and neck cancer patients

  This study is testing whether personalizing treatment for head and neck cancer patients by using different types of radiotherapy can lead to better outcomes.

  Recruiting at 3 sites Phase 3 Lund University Hospital · Gävle and 10 other locations · NCT06248996

• Combination treatment for advanced head and neck cancer

  This study is testing a new combination treatment for people with advanced head and neck cancer to see if it can boost their immune response and help fight the disease.

  Recruiting at 2 sites Phase 2 Dana-Farber Cancer Institute · Boston, Massachusetts and 1 other locations · NCT06239220

• Treatment of advanced head and neck cancer with SIBP-03

  This study is testing a new treatment called SIBP-03 for people with advanced head and neck cancer to see if it works better than a placebo and how safe it is.

  Recruiting at 2 sites Phase 2 Shanghai Institute Of Biological Products · Shanghai, Shanghai Municipality and 1 other locations · NCT06194656

• Evaluating skin reactions in head and neck cancer patients receiving proton therapy

  This study is testing a new way to reduce skin reactions in head and neck cancer patients getting proton therapy by using a special technique and personalized treatment plans.

  Recruiting Covenant Health Cancer Center · Knoxville, Tennessee · NCT06183268

• Combining chemotherapy and immunotherapy for high-risk head and neck cancer patients after surgery

  This study is testing if adding a new immune treatment to standard chemotherapy after surgery can help high-risk head and neck cancer patients stay cancer-free longer.

  Recruiting Phase 2 Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Beijing, Beijing Municipality · NCT06170710

• Longitudinal biomarker profiling for patients with head and neck cancer

  This study is trying to see how the molecular makeup of head and neck cancer changes over time in patients who are receiving first-line anti-PD1 or PDL1 therapy.

  Recruiting at 31 sites Tempus AI · Duarte, California and 31 other locations · NCT06163534

• Using methylnaltrexone before surgery for head and neck cancer

  This study is testing if giving methylnaltrexone to patients with oral cavity squamous cell carcinoma for two weeks before surgery is safe and tolerable.

  Recruiting Phase 4 M.D. Anderson Cancer Center · Houston, Texas · NCT06162377

• Testing CTX-8371 in patients with advanced cancers

  This study is testing a new treatment called CTX-8371 in patients with advanced cancers to see if it can help them when other treatments haven't worked.

  Recruiting at 11 sites Phase 1 Compass Therapeutics · Birmingham, Alabama and 11 other locations · NCT06150664

• Combining Pembrolizumab with Chemotherapy for Advanced Head and Neck Cancer

  This study is testing whether adding a drug called pembrolizumab to standard chemotherapy can help people with advanced head and neck cancer respond better to treatment.

  Recruiting Phase 3 Beijing Tongren Hospital · Beijing, Beijing Municipality · NCT06102395

• Combining PD-1 therapy with chemotherapy for advanced head and neck cancer

  This study is testing if combining a new cancer treatment with chemotherapy can help people with advanced head and neck cancer feel better and have better outcomes.

  Recruiting Phase 2 Beijing Tongren Hospital · Beijing, Beijing Municipality · NCT06100497

• New blood test to reduce radiation in HPV-related throat cancer treatment

  This study is testing a new blood test to see if it can help identify patients with HPV-related throat cancer who might not need radiation after surgery, aiming to reduce side effects while keeping survival rates high.

  Recruiting at 2 sites Phase 2 University of Maryland, Baltimore · Baltimore, Maryland and 4 other locations · NCT06088381

• Escalating radiation doses for head and neck cancer treatment

  This study is testing whether giving higher doses of radiation to certain areas of head and neck cancer can help patients with hypoxic tumors do better than with standard treatment.

  Recruiting Phase 2 Rajiv Gandhi Cancer Institute & Research Center, India · Delhi · NCT06087614

• Assessing the effects of ABBV-400 on advanced solid tumors

  This study is testing a new drug called ABBV-400 to see if it can help adults with advanced solid tumors like liver, pancreatic, and triple negative breast cancer feel better and manage their disease.

  Recruiting at 47 sites Phase 1 AbbVie · Duarte, California and 53 other locations · NCT06084481

• Testing NEO212 for treating certain brain tumors and metastases

  This study is testing a new treatment called NEO212 for people with certain types of brain tumors to see if it is safe and effective when combined with standard treatments.

  Recruiting at 8 sites Phase 1/2 Neonc Technologies, Inc. · Beverly Hills, California and 7 other locations · NCT06047379

• Testing ONM-501 alone and with Cemiplimab for advanced solid tumors and lymphomas

  This study is testing a new treatment called ONM-501, both alone and with another drug called cemiplimab, to see if it can help people with advanced solid tumors and lymphomas who have run out of other treatment options.

  Recruiting at 5 sites Phase 1 OncoNano Medicine, Inc. · Los Angeles, California and 15 other locations · NCT06022029

• HS-20093 treatment for head and neck cancer and other solid tumors

  This study is testing a new treatment called HS-20093 to see if it can help people with advanced head and neck cancer and other solid tumors who haven't had success with standard therapies.

  Recruiting at 24 sites Phase 2 Hansoh BioMedical R&D Company · Hefei, Anhui and 24 other locations · NCT06007729

• Investigating new treatments for recurrent or metastatic head and neck cancer

  This study is testing two new drugs to see if they can help people with recurrent or metastatic head and neck cancer feel better when other treatments haven't worked.

  Recruiting Phase 2 Sichuan Baili Pharmaceutical Co., Ltd. · Shanghai, Shanghai Municipality · NCT06006169

• Assessing tumor hypoxia using MRI to improve radiation therapy

  This study is testing if special MRI scans can help doctors understand and improve radiation treatment for patients with head and neck cancer or brain metastases by looking at how much oxygen their tumors are getting.

  Recruiting Early Phase 1 Vanderbilt-Ingram Cancer Center · Nashville, Tennessee · NCT05996432

• Evaluating BL-B01D1 for patients with advanced lung and solid tumors

  This study is testing a new treatment called BL-B01D1 to see if it is safe and effective for people with advanced lung cancer and other solid tumors.

  Recruiting at 37 sites Phase 1 SystImmune Inc. · Beverly Hills, California and 36 other locations · NCT05983432

• HRYZ-T101 injection for HPV18 positive solid tumors

  This study is testing a new injection called HRYZ-T101 to see if it can safely help people with solid tumors that are positive for HPV18.

  Recruiting Phase 1 HRYZ Biotech Co. · Shanghai, Shanghai Municipality · NCT05952947

• Using dual imaging techniques to detect head and neck cancer

  This study is testing two new imaging techniques to see if they can better detect head and neck cancer in patients before surgery.

  Recruiting Phase 1 Vanderbilt-Ingram Cancer Center · Nashville, Tennessee · NCT05945875

• Tirelizumab combined with chemotherapy for treating head and neck cancer

  This study is testing if a new combination of tirelizumab and chemotherapy can help people with head and neck cancer feel better and improve their treatment results before and after surgery.

  Recruiting Phase 2 Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Guangzhou, Guangdong · NCT05941338

• Investigating MRI Biomarkers in Head and Neck Cancer Treatment

  This study is testing if MRI scans can help doctors better tailor treatment for patients with newly diagnosed head and neck cancer to improve their outcomes and reduce side effects.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT05919290

• Testing VLS-1488 for advanced cancers

  This study is testing a new oral medication called VLS-1488 to see if it is safe and effective for people with advanced solid tumors.

  Recruiting at 13 sites Phase 1/2 Volastra Therapeutics, Inc. · Los Angeles, California and 13 other locations · NCT05902988

• Using a radioactive drug to find cancer spread in head and neck patients

  This study is testing a new radioactive drug to see if it can help doctors find cancer spread in the lymph nodes of patients with head and neck cancer before surgery.

  Recruiting Phase 1 Vanderbilt-Ingram Cancer Center · Nashville, Tennessee · NCT05901545

• Using fat flap reconstruction to reduce neck injury after cancer treatment

  This study is testing if a new surgery using fat from the thigh can help people with head and neck cancer feel better and reduce neck problems after their treatment.

  Recruiting Memorial Sloan Kettering Cancer Center · New York, New York · NCT05889091

• Treatment with engineered T cells for advanced solid tumors with a specific mutation

  This study is testing a new T cell therapy for patients with advanced solid tumors that have a specific mutation to see if it can help fight their cancer.

  Recruiting at 16 sites Phase 1 AstraZeneca · Gilbert, Arizona and 19 other locations · NCT05877599

• MQ710 with or without pembrolizumab for advanced skin and other solid tumors

  This will test different doses of MQ710, alone or together with pembrolizumab, in adults with advanced or recurrent solid tumors (including skin cancers) to find a safe dose with mild side effects.

  Recruiting at 5 sites Phase 1 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT05859074

• Reduced postoperative radiotherapy for advanced head and neck cancer

  This study is testing if giving a lower dose of radiation after surgery can help people with advanced head and neck cancer stay cancer-free while causing fewer side effects.

  Recruiting Fifth Affiliated Hospital, Sun Yat-Sen University · Zhuhai, Guangdong · NCT05854823

• Comparing navigation support to standard care for starting radiation therapy in head and neck cancer patients

  This study is testing a new support program to help people with head and neck cancer start their radiation therapy on time compared to the usual care they receive.

  Recruiting at 4 sites Medical University of South Carolina · St Louis, Missouri and 3 other locations · NCT05793151

• Combining TU2218 with KEYTRUDA for advanced solid tumors

  This study is testing a new treatment combining TU2218 and KEYTRUDA to see if it can help people with advanced solid tumors who haven't responded to other therapies.

  Recruiting at 8 sites Phase 1/2 TiumBio Co., Ltd. · San Antonio, Texas and 10 other locations · NCT05784688

• Using a new imaging agent to detect metastases in head and neck cancer

  This study is testing a new imaging agent to see if it can help find hidden cancer spread in people with head and neck cancer better than current methods.

  Recruiting Phase 1 Vanderbilt-Ingram Cancer Center · Nashville, Tennessee · NCT05747625

• Combination of immunotherapy and chemotherapy for head and neck cancer treatment

  This study is testing if combining an immunotherapy drug with chemotherapy before and after surgery can help people with head and neck cancer do better.

  Recruiting Phase 2 Dana-Farber Cancer Institute · Boston, Massachusetts and 1 other locations · NCT05726370

• Using PET/CT to monitor head and neck cancer after treatment

  This study is testing if a special imaging scan can help find any return of head and neck cancer in patients who have finished their treatment.

  Recruiting Copenhagen University Hospital, Rigshospitalet · Copenhagen, Copenhagen · NCT05707078

• Advanced radiation treatment for head and neck cancer palliation

  This study is testing if a new type of radiation treatment can help relieve symptoms and improve quality of life for patients with head and neck cancer who can't be cured.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT05674396

• Evaluating a new imaging agent for detecting head and neck cancer

  This study is testing a new imaging agent to see if it can help doctors find head and neck cancers more easily during surgery, especially in patients with known or unknown cancer.

  Recruiting Phase 2 University of Texas Southwestern Medical Center · Dallas, Texas · NCT05576974

• Reducing radiation and chemotherapy for head and neck cancer treatment

  This study is testing if giving less radiation and chemotherapy before surgery can still effectively treat certain head and neck cancers while reducing side effects for patients.

  Recruiting at 6 sites Phase 2 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 5 other locations · NCT05544136

• Combining radiation with experimental drugs for recurrent head and neck cancer

  This study is testing a new combination of experimental drugs and radiation therapy to see if it can safely help people with recurrent head and neck cancer.

  Recruiting Phase 1 University of Chicago · Chicago, Illinois · NCT05526924

• Combination of pembrolizumab and low-dose chemotherapy for advanced head and neck cancer

  This study is testing if combining a new immune therapy with low-dose chemotherapy can help people with advanced head and neck cancer before their main treatment.

  Recruiting at 6 sites Phase 2 Zhejiang Provincial People's Hospital · Qingdao, Shandong and 6 other locations · NCT05446467

• Using Pembrolizumab with Chemotherapy for Head and Neck Cancer

  This study is testing if combining a blood test that checks tumor DNA with chemotherapy and immunotherapy can help people with head and neck cancer get better results than using immunotherapy alone.

  Recruiting Phase 2 University of Chicago · Chicago, Illinois · NCT05420948

• Pembrolizumab with nab-paclitaxel and cisplatin for locally advanced head and neck cancer

  This trial tries adding pembrolizumab to nab-paclitaxel and cisplatin as initial treatment for adults with resectable, locally advanced head and neck squamous cell carcinoma to see if it increases tumor shrinkage and organ preservation.

  Recruiting Phase 2 Guangdong Provincial People's Hospital · Guangzhou, Guangdong · NCT05272696

• Using a new imaging method to locate head and neck cancer tumors

  This study is testing a new imaging method to see if it can better find and measure head and neck cancer tumors compared to the usual imaging technique.

  Recruiting Early Phase 1 University of Alabama at Birmingham · Birmingham, Alabama · NCT05183048

• Evaluating NX-1607 for advanced cancers

  This study is testing a new treatment called NX-1607 to see if it can help people with advanced cancers who have run out of other options.

  Recruiting at 15 sites Phase 1 Nurix Therapeutics, Inc. · Duarte, California and 16 other locations · NCT05107674

• Combination treatment for advanced head and neck cancer using radiation and immunotherapy

  This study is testing a new treatment for advanced head and neck cancer that combines a special type of radiation with an immunotherapy drug to see if it helps patients with hard-to-treat tumors.

  Recruiting at 2 sites Alpha Tau Medical LTD. · Jerusalem and 2 other locations · NCT05047094

• Using virtual reality to improve head and neck cancer surgery

  This study is testing if using virtual reality during surgery can help improve outcomes for patients with head and neck cancer.

  Recruiting Thomas Jefferson University · Philadelphia, Pennsylvania · NCT05031910

• Assessing the safety and effects of Azirkitug in cancer patients

  This study is testing a new cancer drug called Azirkitug to see how safe it is and how well it works for adults with certain types of lung and head and neck cancers.

  Recruiting at 47 sites Phase 1 AbbVie · Duarte, California and 47 other locations · NCT05005403

• Pembrolizumab with chemotherapy for advanced head and neck cancer in China

  This study is testing if combining pembrolizumab with chemotherapy can help people in China with advanced head and neck cancer feel better and live longer.

  Recruiting Phase 2 Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Beijing, Beijing Municipality · NCT04857164

• Preoperative treatment for head and neck cancer using Toripalimab with chemotherapy

  This study is testing if the drug Toripalimab, alone or with chemotherapy, can safely help people with head and neck cancer before their surgery.

  Recruiting Phase 2 Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Guangzhou, Guangdong · NCT04807140

• Combining chemotherapy and immunotherapy for head and neck cancer treatment

  This study is testing if combining chemotherapy with immunotherapy drugs can help people with head and neck cancer before surgery and possibly reduce the need for radiation therapy afterward.

  Recruiting at 7 sites Phase 1 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT04722523

• Combination treatment with a PARP inhibitor and immunotherapy for HPV-negative head and neck cancer

  This study is testing a new combination of two treatments for people with HPV-negative head and neck cancer to see if it can help them before and after surgery.

  Recruiting Phase 2 Gruppo Oncologico del Nord-Ovest · Brescia · NCT04681469

• Identifying Methylation Patterns in Head and Neck Cancer

  This study is trying to find unique chemical patterns in the blood of people with head and neck cancer to better understand the disease.

  Recruiting Aalborg University Hospital · Aalborg · NCT04567056

• Observing HPV DNA and genetic markers in oropharyngeal cancer

  This study is testing if checking for certain gene changes and HPV DNA in the blood can help predict if oropharyngeal cancer will come back in newly diagnosed patients.

  Recruiting at 2 sites UNC Lineberger Comprehensive Cancer Center · Rochester, Minnesota and 2 other locations · NCT04564989

• Investigating BCA101 for advanced solid tumors driven by EGFR

  This study is testing a new treatment called BCA101 to see if it can help people with advanced solid tumors that are driven by EGFR, especially those who haven't responded to other therapies.

  Recruiting at 21 sites Phase 1 Bicara Therapeutics · La Jolla, California and 20 other locations · NCT04429542

• Cetuximab treatment for advanced head and neck cancer after immunotherapy

  This study is testing if the drug Cetuximab can help people with advanced head and neck cancer who didn’t respond to or couldn’t tolerate previous immunotherapy treatments.

  Recruiting Phase 2 Wake Forest University Health Sciences · Winston-Salem, North Carolina · NCT04375384

• Gene modified immune cells for treating advanced melanoma and metastatic solid tumors

  This study is testing if modified immune cells can safely target and attack advanced melanoma and other solid tumors in patients after they receive chemotherapy.

  Recruiting at 3 sites Phase 1 Stanford University · Duarte, California and 2 other locations · NCT04119024

• Combining a special virus with immune cells to treat advanced HER2 positive cancers

  This study is testing a new treatment that combines a special virus and immune cells to see if it can help people with advanced HER2 positive cancers.

  Recruiting Phase 1 Baylor College of Medicine · Houston, Texas · NCT03740256

• Treatment of solid tumors or lymphoma with VMD-928

  This study is testing a new oral medication called VMD-928 to see if it can help adults with advanced solid tumors or lymphoma that haven't improved with standard treatments.

  Recruiting at 13 sites Phase 1/2 VM Oncology, LLC · Santa Rosa, California and 12 other locations · NCT03556228

• Testing a new bispecific antibody for advanced solid tumors

  This study is testing a new treatment called MCLA-158 to see if it can help people with advanced solid tumors, especially those with metastatic colorectal cancer, when other options have run out.

  Recruiting at 45 sites Phase 1/2 Genmab · La Jolla, California and 53 other locations · NCT03526835

• Immunotherapy after surgery for head and neck cancer

  This study is testing if a new immunotherapy treatment after surgery can help people with recurring head and neck cancer live longer without the disease coming back, compared to older treatments.

  Recruiting Phase 2 Gustave Roussy, Cancer Campus, Grand Paris · Villejuif, Val De Marne · NCT03406247

• Reducing radiation therapy for HPV-positive head and neck cancer

  This study is testing if giving less radiation after surgery helps people with HPV-positive head and neck cancer avoid side effects while still keeping the cancer under control.

  Recruiting at 9 sites Technische Universität Dresden · Tübingen, Baden-Wurttemberg and 9 other locations · NCT03396718

• Comparing radiation therapy alone or with cisplatin for advanced head and neck cancer after surgery

  This study is testing whether adding the chemotherapy drug cisplatin to radiation therapy helps people with advanced head and neck cancer feel better after surgery compared to just radiation alone.

  Recruiting at 463 sites Phase 2 Eastern Cooperative Oncology Group · Birmingham, Alabama and 678 other locations · NCT02734537

Related topics

Quick answers

How many Head and Neck Squamous Cell Carcinoma clinical trials are recruiting right now?

125, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 25 countries. The most sites are in United States (68 trials), China (39 trials), Spain (8 trials), Italy (7 trials), South Korea (7 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 46, Phase 1: 35, Phase 1/2: 13, Early Phase 1: 5. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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