Condition

Cutaneous Squamous Cell Carcinoma clinical trials and research

• 20Clinical trials
• 12NIH research projects
• 1New in 30 days
• 7Countries

Newest Cutaneous Squamous Cell Carcinoma clinical trials

All recruiting trials (20)

• Cemiplimab with Quad Shot Radiation for Head and Neck Cutaneous Squamous Cell Carcinoma

  This study tests whether giving cemiplimab together with a short course of Quad Shot radiation can be safely delivered in several rounds to elderly or frail patients with head and neck skin cancer.

  Recruiting Early Phase 1 Vanderbilt-Ingram Cancer Center · St Louis, Missouri · NCT07869823

• IDP-001 in advanced or metastatic solid tumors (including head and neck and skin cancers)

  A first- and second-phase study will test IDP-001 in people with advanced or metastatic solid tumors to see if it is safe and tolerable and to look for signs of activity.

  Recruiting at 6 sites Phase 1/2 InduPro, Inc. · Los Angeles, California and 5 other locations · NCT07602842

• Cosibelimab for tough CSCC in kidney transplant recipients or blood cancers

  This trial tests cosibelimab in people with advanced cutaneous squamous cell carcinoma who have a kidney transplant or certain blood cancers to see if it is safe and helpful for them.

  Recruiting at 2 sites Phase 4 Dana-Farber Cancer Institute · Boston, Massachusetts and 1 other locations · NCT07426484

• 3D ultrasound of removed cutaneous squamous cell carcinoma specimens

  For adults having surgery to remove cutaneous squamous cell carcinoma, this will try ex vivo 3D ultrasound of the removed specimen to see if it can accurately measure the deep margin compared with standard pathology.

  Recruiting Copenhagen University Hospital, Rigshospitalet · Copenhagen · NCT07402616

• Lifileucel (TIL) plus chemotherapy and IL-2 for advanced cutaneous squamous cell and Merkel cell carcinoma

  This trial will try lifileucel (tumor-infiltrating lymphocytes) combined with lymphodepleting chemotherapy and interleukin-2 in adults with unresectable or metastatic cutaneous squamous cell carcinoma or Merkel cell carcinoma who have previously received immunotherapy.

  Recruiting Phase 2 Dana-Farber Cancer Institute · Boston, Massachusetts · NCT07288073

• Using blood tests to monitor skin cancer treatment

  This study is testing whether blood tests can help track how well treatment is working for people with skin cancer called cutaneous squamous cell carcinoma.

  Recruiting Massachusetts Eye and Ear Infirmary · Boston, Massachusetts · NCT06875609

• Using immunotherapy to treat cutaneous squamous cell carcinoma without surgery

  This study is testing if a combination of immunotherapy drugs can help patients with skin cancer avoid surgery.

  Recruiting Phase 2 The Netherlands Cancer Institute · Maastricht, Limburg and 4 other locations · NCT06823479

• Adding superficial heat therapy (wIRA) to standard palliative radiotherapy

  This project will test whether adding superficial hyperthermia (wIRA) to standard palliative radiotherapy helps control superficial tumours in adults with inoperable or recurrent head and neck, cutaneous, or recurrent breast cancers.

  Recruiting at 2 sites King's College London · London and 1 other locations · NCT06659146

• Testing ivonescimab for advanced skin cancer

  This study is testing if ivonescimab can help people with advanced skin cancer feel better and control their disease.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT06567314

• Personalized immunotherapy platform for cancer treatment

  This study is testing a new way to identify melanoma and skin cancer patients who might not respond well to immunotherapy by analyzing their tumor samples.

  Recruiting at 3 sites Melanoma Institute Australia · Sydney, New South Wales and 2 other locations · NCT06536257

• Neoadjuvant therapy using Nivolumab and Relatlimab for skin cancer

  This study is testing a new combination of two immunotherapy drugs, Nivolumab and Relatlimab, to see if they can help people with advanced skin cancer do better before surgery.

  Recruiting Phase 2 Melanoma Institute Australia · Wollstonecraft, New South Wales · NCT06288191

• Testing a new treatment for advanced solid tumors

  This study is testing a new treatment called tolododekin alfa for people with advanced solid tumors that haven't improved with standard therapies to see how safe it is and how well it works.

  Recruiting at 5 sites Phase 1 Ankyra Therapeutics, Inc · Bethesda, Maryland and 4 other locations · NCT06171750

• MQ710 with or without pembrolizumab for advanced skin and other solid tumors

  This will test different doses of MQ710, alone or together with pembrolizumab, in adults with advanced or recurrent solid tumors (including skin cancers) to find a safe dose with mild side effects.

  Recruiting at 5 sites Phase 1 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT05859074

• Analyzing real-world treatment data for advanced skin cancer patients in Europe

  This study looks at real-world treatment experiences of people in Europe with advanced skin cancer to see how they are being treated and what outcomes they have.

  Recruiting EuMelaReg gGmbH · Brussels · NCT05741073

• Evaluating staging systems for skin cancer

  This study is trying to see how well current staging systems for skin cancer can predict serious outcomes in people with cutaneous squamous cell carcinoma.

  Recruiting Queen Mary University of London · London and 1 other locations · NCT05695222

• Microneedle patches delivering doxorubicin for skin cancer treatment

  This study is testing a new way to treat skin cancer by using tiny microneedle patches to deliver a cancer-fighting drug directly to the tumor, focusing on both healthy and immunocompromised patients.

  Recruiting Phase 1/2 University of Pittsburgh · Pittsburgh, Pennsylvania · NCT05377905

• Using sentinel lymph node biopsy to assess cutaneous squamous cell carcinoma in the head and neck

  This study is testing if a special biopsy can help find hidden tumors in patients with a certain type of skin cancer in the head and neck to see if they need more intense treatment.

  Recruiting Indiana University · Indianapolis, Indiana · NCT05108090

• Oncolytic virus treatment combined with nivolumab for advanced solid tumors

  This study is testing a new virus treatment combined with an existing cancer drug to see if it can help people with advanced solid tumors, like lung cancer, whose cancer has not improved with previous treatments.

  Recruiting Phase 1 Memgen, Inc. · Tampa, Florida and 1 other locations · NCT05076760

• Using Cemiplimab before surgery for skin cancers

  This study is testing if giving a new immunotherapy drug before surgery can help people with certain types of skin cancer have better outcomes.

  Recruiting Phase 1 H. Lee Moffitt Cancer Center and Research Institute · Tampa, Florida · NCT04975152

• Investigating BCA101 for advanced solid tumors driven by EGFR

  This study is testing a new treatment called BCA101 to see if it can help people with advanced solid tumors that are driven by EGFR, especially those who haven't responded to other therapies.

  Recruiting at 21 sites Phase 1 Bicara Therapeutics · La Jolla, California and 20 other locations · NCT04429542

NIH-funded research (12)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Genomic map of cutaneous squamous cell carcinoma and its earliest genetic changes

  This project looks at the genes involved in a common skin cancer (cutaneous squamous cell carcinoma) to understand what mutations drive its growth and how it evolves from benign skin lesions.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11398277

• Genetic landscape and evolution of cutaneous squamous cell carcinoma

  Researchers will look at DNA changes in skin squamous cell carcinoma and in nearby precursor lesions to find mutations that drive the cancer.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11136374

• Understanding Twist1 to Prevent and Treat Skin Cancer

  This work explores how a protein called Twist1 contributes to squamous cell skin cancer and aims to find new ways to stop or treat this disease.

  NIH research University of Texas at Austin · Austin, United States · NIH-11092757

• Understanding the genetic changes in skin cancer

  This study is looking at how certain genetic changes in skin cells can lead to squamous cell carcinoma, a type of skin cancer, by comparing cancerous spots with their non-cancerous beginnings, to help find better ways to catch and treat this cancer early for patients like you.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11064287

• Exploring how epigenetic changes affect skin cancer development

  This study is looking at how a specific gene might affect the development of skin cancer, especially in military personnel who are often exposed to the sun, with the hope of finding new ways to treat this common condition.

  NIH research Minneapolis VA Medical Center · Minneapolis, United States · NIH-10927704

• Understanding the genetic changes in skin cancer

  This study is looking at how certain genetic changes in skin cells can turn a harmless skin condition into squamous cell carcinoma, a type of skin cancer, to help find better ways to diagnose and treat it.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-10914884

• Investigating T cells that target specific cancer proteins in skin cancer

  This study is looking at how certain immune cells can help fight a common skin cancer called cutaneous squamous cell carcinoma (cSCC), using a mouse model to learn how to make treatments that boost the immune system even better for patients.

  NIH research University of Arizona · Tucson, United States · NIH-10899423

• Understanding how immune responses affect skin cancer development

  This study is looking at how the immune system responds to skin cancer in people who have had organ transplants and are more likely to get this type of cancer, to find out how the cancer hides from the immune system and discover new ways to treat it.

  NIH research University of Arizona · Tucson, United States · NIH-10880258

• Investigating Twist1 for preventing and treating skin cancer

  This study is looking at a protein called Twist1 to see how it influences skin cancer, specifically cutaneous squamous cell carcinoma, and aims to find new ways to target it to help prevent and treat this type of skin cancer, especially in relation to how skin cells react to UV light.

  NIH research University of Texas at Austin · Austin, United States · NIH-10876471

• Understanding genetic changes in skin cancer progression

  This study is looking at how certain genetic changes in skin cancer can help us understand why it spreads and how to find better treatments, and we’re inviting patients to share their genetic samples and health information to help with this important research.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-10836131

• Targeting genetic changes to treat skin cancer

  This study is looking at how long-term sun exposure affects your genes and may lead to skin cancer, and it hopes to find new ways to reverse these changes to help stop tumor growth, which could lead to better treatments for people with skin cancer.

  NIH research University of Washington · Seattle, United States · NIH-10705718

• New topical cream to treat precancerous skin lesions and prevent skin cancer.

  This study is testing a new cream that combines two medicines to help treat actinic keratosis and lower the chances of getting skin cancer, and it's designed for people who want a more effective and easy-to-use treatment for these skin issues.

  NIH research Phd Skin Care LLC · La Jolla, UNITED STATES · NIH-10701001

Related topics

Quick answers

How many Cutaneous Squamous Cell Carcinoma clinical trials are recruiting right now?

20, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 7 countries. The most sites are in United States (13 trials), Australia (3 trials), United Kingdom (2 trials), Canada (2 trials), Denmark (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 5, Phase 2: 4, Phase 1/2: 2, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →