CCR2 PET imaging in head and neck cancer

Who could benefit from this research

What this research studies

This project aims to use a CCR2-targeted PET radiotracer, 64Cu-DOTA-ECL1i, to image tumors and tumor-associated macrophages in patients with newly diagnosed head and neck squamous cell carcinoma. By combining PET/CT imaging with biomarker information, doctors may better predict prognosis and tailor therapies for each patient. The study builds on prior findings showing CCR2 expression is linked with worse outcomes and that the tracer can visualize CCR2+ cells in tumors. Enrollment would involve imaging participants and correlating imaging findings with clinical outcomes and pathology. The goal is to create an imaging biomarker that helps select the most effective treatment strategy for HNSCC patients.

Why it matters

Where this research is happening

• Washington University
  Saint Louis, United States Active

Researchers

• Principal investigator: Dehdashti, Farrokh — Washington University
• Study coordinator: Dehdashti, Farrokh

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.