Condition

Adenocarcinoma clinical trials and research

• 19Clinical trials
• 174NIH research projects
• 10Countries

Newest Adenocarcinoma clinical trials

All recruiting trials (19)

• Methionine-Reduced Diet in Solid Tumors (early-phase)

  A small pilot study will test whether a methionine-reduced diet can change blood levels in adults with various solid tumors who are receiving standard cancer therapy.

  Recruiting Early Phase 1 University of California, Irvine · Orange, California · NCT07628634

• TriAdeno and N-803 vaccine in early prostate cancer on active surveillance

  A vaccine combo called TriAdeno plus the N-803 drug is being tested to see if it can help slow or stop growth in men with early-stage, low- to intermediate-risk prostate cancer who are being watched rather than treated right away.

  Recruiting Phase 2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT07574541

• LM-302 with tislelizumab plus chemotherapy for stomach and gastroesophageal junction cancer

  This phase 3 study tests whether LM-302 added to tislelizumab is better or safer than tislelizumab with chemotherapy in patients with newly diagnosed, unresectable or metastatic stomach/GEJ adenocarcinoma that express CLDN18.2.

  Recruiting Phase 3 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. · Hefei, Anhui and 105 other locations · NCT07385703

• Relacorilant with nab-paclitaxel and gemcitabine for metastatic pancreatic adenocarcinoma

  This trial tests whether adding relacorilant to standard chemotherapy (nab-paclitaxel plus gemcitabine) helps people with previously untreated metastatic pancreatic adenocarcinoma.

  Recruiting at 19 sites Phase 2 Corcept Therapeutics · Scottsdale, Arizona and 19 other locations · NCT07259317

• Long-term clinical and tissue data collection for people with thoracic cancers

  This project will collect medical records, imaging, quality-of-life information, and tissue/blood samples over time from adults with thoracic cancers to try to find factors that predict outcomes.

  Recruiting at 11 sites Dutch Society of Physicians for Pulmonology and Tuberculosis · Ede, Gelderland and 22 other locations · NCT06996249

• Multimodal ablation with Tislelizumab, lenvatinib and TACE for unresectable primary liver cancer

  This trial will test whether combining multimodal ablation with Tislelizumab (a PD‑1 antibody), lenvatinib, and TACE helps people with unresectable primary liver cancer.

  Recruiting Shanghai Zhongshan Hospital · Shanghai, Shanghai Municipality · NCT06794073

• Evaluating the effects of oxaliplatin on liver and nerve toxicity in cancer patients

  This study is testing how the cancer drug oxaliplatin affects the liver and nerves in patients with pancreatic and esophageal cancers to help make chemotherapy safer and more effective.

  Recruiting University Hospital, Clermont-Ferrand · Clermont-Ferrand · NCT06649474

• Young adults with gastrointestinal and neuroendocrine cancers

  This study is trying to gather samples from young adults with gastrointestinal and neuroendocrine cancers to learn more about their specific needs and improve treatment options for them.

  Recruiting European Institute of Oncology · Milan · NCT06337760

• Biobank for pancreatic adenocarcinoma research

  This study is collecting samples and information from people with pancreatic cancer to help find better ways to diagnose and treat the disease.

  Recruiting University Hospital, Toulouse · Béthune and 7 other locations · NCT06128343

• Combining radiotherapy and immunotherapy for limited metastatic gastric cancer

  This study is testing a new treatment that combines radiation, chemotherapy, and immunotherapy to see if it can help people with limited metastatic gastric cancer live longer and improve their health.

  Recruiting Phase 2 Fudan University · Shanghai · NCT06121700

• Understanding factors affecting prostate cancer progression

  This study is trying to find out what factors affect how prostate cancer grows in different people to help improve treatment and prevention for those at higher risk.

  Recruiting Centre Hospitalier Universitaire de la Guadeloupe · Rennes, Ille-et-Vilaine and 1 other locations · NCT06046131

• Platform program for evaluating treatments in metastatic HER2-positive breast cancer

  This study is testing different new treatments for people with advanced HER2-positive breast cancer to see which ones work best before moving them to larger trials.

  Recruiting at 5 sites Phase 1/2 QuantumLeap Healthcare Collaborative · Birmingham, Alabama and 9 other locations · NCT05868226

• Surgery followed by tailored treatment for advanced cervical cancer

  This study is testing whether surgery followed by personalized treatment can help women with advanced cervical cancer live longer and healthier compared to standard treatment alone.

  Recruiting at 33 sites Phase 3 Institut Claudius Regaud · Ostrava and 36 other locations · NCT05581121

• Evaluating MRI and biopsy methods for prostate cancer detection

  This study is testing whether a new type of MRI and a different way to do biopsies can help find prostate cancer more accurately in men who might have it.

  Recruiting at 14 sites Imperial College London · Southend-on-Sea, Essex and 14 other locations · NCT05574647

• Creating a serum bank to find early markers for pancreatic cancer

  This study is trying to collect blood samples from people with pancreatic cancer to see if certain markers can help catch the disease earlier.

  Recruiting at 2 sites Centre Hospitalier Universitaire de Saint Etienne · Saint-Etienne and 1 other locations · NCT04374175

• Combining irinotecan with multiple chemotherapy agents for cancer treatment

  This study is testing a new combination of chemotherapy drugs, including irinotecan, to see if it can safely help people with advanced gastrointestinal cancers like pancreatic and gastroesophageal junction adenocarcinoma who haven't had success with other treatments.

  Recruiting Phase 1 University of Chicago · Chicago, Illinois · NCT04361708

• Daily online MRI for improving radiotherapy precision

  This study is testing a new way to use MRI scans during radiotherapy to help doctors target tumors more accurately and protect healthy tissue in patients with adenocarcinoma.

  Recruiting Institute of Cancer Research, United Kingdom · Sutton, Surrey · NCT02973828

• Improving treatment planning for recurrent colorectal cancer using MRI

  This study is testing a new way to use MRI scans to help doctors plan better treatments for patients with recurrent colorectal cancer.

  Recruiting at 4 sites Imperial College London · Oslo and 3 other locations · NCT02292641

• T Cell Receptor Immunotherapy for Metastatic Non-Small Cell Lung Cancer

  This study is testing a new treatment for advanced lung cancer that uses special immune cells from patients' own tumors to see if it can help shrink their cancer.

  Recruiting Phase 2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT02133196

NIH-funded research (newest 40 of 174)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Natural products to block IL-8 signaling and prevent Barrett's Esophagus from turning into esophageal cancer

  A搜索-friendly plan to use safe natural compounds to interrupt a key inflammatory signal (IL-8) and stop Barrett’s esophagus from turning into esophageal cancer in people with GERD.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11580206

• Understanding how CDH1 loss drives aggressive stomach cancer and how to target it

  Researchers are studying why certain advanced stomach cancers grow and spread, with a focus on CDH1 inactivation and related pathways to find ways to improve treatment for patients.

  NIH research Louisiana State Univ Hsc Shreveport · Shreveport, United States · NIH-11512968

• Understanding a highly flexible cell state in lung cancer that worsens outcomes

  A doctor-scientist at Cedars-Sinai wants to learn how a highly adaptable lung cancer cell state drives disease progression and resistance to therapy, using models that resemble human tumors.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-11505050

• Fibrin-rich tumor stroma as a new driver of immune response in pancreatic cancer

  This grant explores how fibrin-involved tumor surroundings in pancreatic cancer might affect immune therapy, with the goal of making treatments work better for patients.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11455114

• TREM2+ macrophages and liver metastases in pancreatic cancer

  Researchers are studying immune cells in liver metastases from pancreatic cancer to understand how they influence the cancer’s spread and more effective treatments.

  NIH research Washington University · Saint Louis, United States · NIH-11452084

• Protein S could slow pancreatic cancer and blood clots

  A potential treatment study looks at restoring a natural blood protein, Protein S, to help people with pancreatic cancer by slowing tumor growth and reducing dangerous clots.

  NIH research Lsu Health Sciences Center · New Orleans, United States · NIH-11450513

• Overcoming Immunotherapy Resistance in Metastatic Gastric/Esophageal Cancer

  A Mayo Clinic-led study aims to find better combos of immune therapy and standard treatment to help people with metastatic gastric and esophageal cancer who don’t respond well to current options.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11448895

• NEK2's role in esophageal cancer development

  A study looking at how the NEK2 protein contributes to the development and progression of esophageal adenocarcinoma in conditions like Barrett’s esophagus.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11448644

• In vivo B7-H3 CAR-T cells for pancreatic cancer therapy

  A patient-friendly look at a new approach that aims to produce CAR-T cells directly inside the body to target pancreatic cancer.

  NIH research Mucommune, LLC · Morrisville, UNITED STATES · NIH-11416630

• Common stem cell origin in Barrett's-related cancers

  This research looks at whether a single stem cell type drives both esophageal and gastric cancers that arise from Barrett’s esophagus, with the aim of finding shared clues to prevent or treat these diseases.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11416592

• PASSCODE: Coordinating and Sharing PDAC stromal research data

  A networked effort at NYU School of Medicine aims to study how the pancreatic cancer stroma shapes tumor growth and patient outcomes, by coordinating researchers, sharing data, and educating the field.

  NIH research New York University School of Medicine · New York, United States · NIH-11413859

• Metabolic changes in pancreatic cancer when treated with crisantaspase

  Aims to understand how pancreatic cancer cells adapt their metabolism when treated with crisantaspase to inform better treatment strategies for patients.

  NIH research West Virginia University · Morgantown, United States · NIH-11413687

• New combination therapy for pancreatic cancer in animals

  A new therapy designed to weaken the tumor’s protective surroundings and boost treatment effects in pancreatic cancer models.

  NIH research Proda Biotech, LLC · Marietta, United States · NIH-11409793

• Novel combo therapy using oncolytic adenovirus and immune drugs for pancreatic cancer

  Aims to combine an oncolytic virus with immune therapies to help shrink pancreatic tumors before surgery and keep them from coming back.

  NIH research Uinta Bio, INC. · Park City, UNITED STATES · NIH-11407396

• Oncostatin M Receptor in Pancreatic Cancer

  Aims to understand how a molecule called Oncostatin M and its receptor affect pancreatic cancer to find new ways to help patients.

  NIH research Portland VA Medical Center · Portland, United States · NIH-11402385

• 5mC and 5hmC DNA blood biomarkers for early detection of pancreatic cancer

  A blood-based test using DNA modifications (5mC and 5hmC) is being developed to detect pancreatic cancer early, aiming to catch the disease before it advances.

  NIH research Beckman Research Institute/city of Hope · Duarte, United States · NIH-11400457

• Improving Early PDAC Detection Using Electronic Medical Records

  A patient-centered approach to use electronic health records to spot signs of pancreatic cancer early, especially in people with new or changing blood sugar levels.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-11399853

• Shared stem cell source for lower esophagus and upper stomach cancers

  This project looks at whether the same type of stem cell drives cancers that start in Barrett's esophagus and the nearby stomach, with implications for people who have Barrett's esophagus or gastric intestinal metaplasia.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11399448

• Total Neoadjuvant Therapy for Borderline or Locally Advanced Pancreatic Cancer

  A multi-part treatment approach tests giving all chemotherapy and targeted radiotherapy before surgery to help patients with tough-to-remove pancreatic cancer become eligible for curative surgery.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11397470

• Understanding why some esophageal cancer patients don’t respond to chemoradiation

  A research project at MD Anderson is looking at why esophageal cancer patients often don’t fully respond to chemoradiation and how tumor biology and the surrounding environment affect treatment.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11395551

• Low-dose, motion-aware MRI to study pancreatic cancer

  A new MRI method using low-dose contrast and motion-resolved imaging is being explored to better characterize pancreatic cancer in patients.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11394353

• AI-powered screening to detect Barrett’s esophagus and early esophageal cancer

  A Mayo Clinic team is testing an AI-assisted tool that uses health data to identify people at risk for Barrett’s esophagus and early esophageal cancer so they can get timely endoscopic evaluation.

  NIH research Mayo Clinic Arizona · Scottsdale, United States · NIH-11384589

• Breaking cytokine loops in LKB1-mutant lung cancer and the immune system

  A researcher at NYU School of Medicine is studying why a common lung cancer subtype with a specific mutation doesn’t respond well to current immunotherapy, with the aim of finding new ways to improve treatment.

  NIH research New York University School of Medicine · New York, United States · NIH-11381978

• Mucin-1 targeted nanoparticles delivering chemotherapy for pancreatic cancer

  A new targeted nanoparticle system is being developed to deliver chemotherapy directly to pancreatic cancer cells in order to improve treatment outcomes.

  NIH research University of North Carolina Charlotte · Charlotte, United States · NIH-11380928

• Lung Adenocarcinoma: From Genome Changes to New Therapies

  This NIH grant supports research on lung adenocarcinoma to better understand its genome changes and translate that knowledge into better diagnosis and treatments for patients.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-11380915

• Understanding how lung cancer and immune cells influence each other in early lung cancer development

  A study looks at how lung cells and immune cells change together as early lung cancer (lung adenocarcinoma) develops, with the goal of finding points to intervene early.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11371145

• Making pancreatic cancer early by intercepting the disease before it progresses

  A researchers are testing strategies to catch and stop pancreatic cancer early, aiming to prevent it from becoming deadly.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11366831

• Understanding how immune-friendly cancer-associated fibroblasts shape pancreatic cancer

  Aimed at mapping a special type of support cell in pancreatic cancer to see how it helps the tumor hide from the immune system and resist treatment.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11366758

• Autophagy and AMPK in pancreatic cancer metabolism

  A cancer research program tests how a cellular recycling process (autophagy) driven by AMPK affects pancreatic cancer growth and treatment resistance.

  NIH research Salk Institute for Biological Studies · La Jolla, UNITED STATES · NIH-11364227

• Overcoming therapeutic resistance in pancreatic cancer

  Researchers are tackling why pancreatic ductal adenocarcinoma often outsmarts treatments and exploring new ways to overcome it to help patients live longer.

  NIH research Salk Institute for Biological Studies · La Jolla, UNITED STATES · NIH-11364210

• SOX4-driven transcription in esophageal cancer

  Researchers are studying how a specific gene network drives esophageal cancer that can arise from Barrett's esophagus, aiming to uncover new targets for therapy.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11362549

• Understanding how a DNA repair protein helps esophageal cancer resist treatment

  A new NIH grant is exploring how a DNA repair protein called APE1 helps esophageal cancer cells survive and resist chemotherapy in Barrett’s esophagus toward preventing or treating esophageal cancer.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11362545

• Disruption of Transcription Networks in Esophageal Adenocarcinoma Tumorigenesis

  A research program at a major medical school is studying how certain gene networks and cellular processes contribute to the development of esophageal cancer in people with Barrett's esophagus and reflux.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11362544

• Targeting a cancer pathway to stop metastasis in SMARCA4-deficient lung cancer

  This grant aims to understand and interrupt a key pathway that drives spread of a specific type of lung cancer in people whose tumors have SMARCA4 mutations.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11361630

• Combining imaging and biopsy genes to spot aggressive vs. slow-growing early lung cancer before surgery

  Aimed at people with early-stage lung adenocarcinoma, this project tests a combined imaging and biopsy gene‑marker approach to better predict tumor aggressiveness before surgery.

  NIH research Boston University Medical Campus · Boston, United States · NIH-11361072

• SOAT1 as a target in pancreatic cancer

  Researchers are studying a specific enzyme, SOAT1, to see if blocking it can slow down or stop pancreatic cancer progression in models that mimic human disease.

  NIH research Cold Spring Harbor Laboratory · Cold Spring Harbor, United States · NIH-11360158

• Collagen-targeted PET imaging to guide pancreatic cancer treatment planning

  A doctor-scientist at a major hospital is testing a new PET imaging probe to better map fibrosis in pancreatic cancer so treatments can be planned more accurately.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11353991

• Aberrant glycogen in lung adenocarcinoma tumor growth

  A new project will study how abnormal glycogen in lung adenocarcinoma tumors may drive cancer growth and help identify targets for future therapies.

  NIH research University of Florida · Gainesville, United States · NIH-11350893

• Early detection biomarkers for pancreatic cancer and high-risk lesions

  A study at Johns Hopkins aims to find blood-based biomarkers that could flag pancreatic cancer and high-risk precursor lesions early, especially in people already under surveillance.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11348928

• Origins of lung adenocarcinoma from lung cells like AT1 and AT2

  A cancer research project is exploring where a common form of lung cancer starts in the lung’s air sacs and how it develops.

  NIH research Beckman Research Institute/city of Hope · Duarte, United States · NIH-11348850

Related topics

Quick answers

How many Adenocarcinoma clinical trials are recruiting right now?

19, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 10 countries. The most sites are in United States (6 trials), France (5 trials), China (3 trials), United Kingdom (3 trials), Italy (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 4, Phase 3: 2, Phase 1/2: 1, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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