Novel idea: Epstein-Barr virus and eye cancer in people living with HIV in Zimbabwe

Who could benefit from this research

What this research studies

This project looks at a potential viral cause of conjunctival squamous cell carcinoma in people with HIV, focusing on how EBV might contribute to eye cancer in this population. Researchers plan to collect and analyze biological samples to understand the link between EBV and cancer development. The work involves international collaboration, combining laboratory analyses with clinical insights to uncover possible pathways that could inform prevention or treatment. The grant supports a multi-year effort to generate data that could guide future clinical strategies in settings with high HIV prevalence.

Why it matters

Where this research is happening

• H. Lee Moffitt Cancer Ctr & Res Inst
  Tampa, United States Active

Researchers

• Principal investigator: Borok, Margaret Ziona — H. Lee Moffitt Cancer Ctr & Res Inst
• Study coordinator: Borok, Margaret Ziona

Related research

Other NIH-funded projects on the same topics.

• Oral cancer recurrence predictor using tumor microbes and gene activity

  This NIH grant explores how bacteria and immune signals inside oral cancer tumors relate to whether the cancer comes back, with the aim of making a practical risk predictor for patients.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11591548

• Data-driven classification of aggressive tissue traits to predict cancer outcomes in HPV-negative head and neck cancer

  A clinician-science grant uses data science and AI to identify tissue patterns in HPV-negative head and neck cancer that may predict how long patients stay cancer-free.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11505841

• Targeting PIPKIγi5 to boost immune responses against head and neck cancer

  A study to see if blocking a specific enzyme, PIPKIγi5, can make head and neck cancer more visible to the immune system and more responsive to existing immunotherapies.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-11449300

• Targeted approaches for lung squamous cell carcinoma with key gene changes

  A study at a major university is exploring new targets in lung squamous cell carcinoma to help people with this cancer find better treatments.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11449092

• Baculovirus-based therapy to treat head and neck cancer with a gentle, minimally invasive approach

  A new, minimally invasive approach using baculovirus-delivered CRISPR gene editing aims to treat head and neck squamous cell carcinoma while aiming to preserve essential tissues.

  NIH research University of Kentucky · Lexington, United States · NIH-11445557

• Reducing bacteria inside oral cancer tumors to boost immune response

  In people with head and neck cancer, this study tests whether lowering bacteria in tumors can help the immune system fight the cancer better.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11439220

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.