Long-term clinical and tissue data collection for people with thoracic cancers

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, observational Dutch cohort enrolling adults with confirmed or strongly suspected thoracic malignancies and following them from diagnosis until death. Clinical data, imaging, pathology, treatment details, adverse events, and patient-reported outcomes will be collected longitudinally, with optional consent for biobanking of blood, tumor tissue, and imaging for research and AI use. The cohort is designed to serve as an infrastructure for future embedded interventions using a Trials within Cohorts (TwiCs) approach, with separate consent required for non-standard treatments. Recruitment occurs across multiple participating hospitals in the Netherlands and participation requires informed consent.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years;
* Histo/cytopathological proof of a thoracic malignancy, or a strong suspicion (after imaging and multidisciplinary board);
* Informed consent for longitudinal observational data collection;

Exclusion Criteria:

* Mentally challenged patients that are unable to provide conscientious informed consent as determined by the investigator.
* Inability to provide a written or electronic informed consent.

Where it's running

• Ziekenhuis Gelderse Vallei
  Ede, Gelderland, Netherlands Recruiting
• Máxima MC
  Eindhoven, North Brabant, Netherlands Recruiting
• Tergooi MC
  Hilversum, Utrecht, Netherlands Recruiting
• Diakonessenhuis
  Utrecht, Utrecht, Netherlands Recruiting
• Meander MC
  Amersfoort, Netherlands Recruiting
• Mumc+
  Maastricht, Netherlands Recruiting

Study contacts

• Principal investigator: W.K. de Jong, Dr. — UMC Utrecht
• Study coordinator: F.T.A. van der Velde
• Email: dutoc@umcutrecht.nl
• Phone: +31 6 296 86 985

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.