Condition

Severe Asthma clinical trials and research

• 22Clinical trials
• 15NIH research projects
• 45Countries

Newest Severe Asthma clinical trials

All recruiting trials (22)

• Structured physical activity program added to tezepelumab for adults with severe asthma

  A 12-week program to help adults with severe asthma who start tezepelumab see if adding guided physical activity improves activity levels and chances of remission.

  Recruiting University of Leeds · Leeds · NCT07735494

• Exercise program for adults with severe asthma starting biologics

  A tailored exercise program is being tested to see if it helps adults with severe asthma who are starting biologic therapy feel better and breathe better.

  Recruiting Helsinki University Central Hospital · Helsinki · NCT07655037

• Frevecitinib (KN-002) for severe asthma: a 12-week dose-ranging study

  This study tests three doses of frevecitinib vs placebo to see if it helps people with severe asthma not controlled by standard inhaled steroids and LABA therapy.

  Recruiting at 9 sites Phase 2 Kinaset Therapeutics Inc · Lancaster, California and 13 other locations · NCT07532265

• Benralizumab treatment for adults with ABPA and severe asthma

  This will test whether benralizumab helps adults (18–75) who have severe asthma with allergic bronchopulmonary aspergillosis (ABPA).

  Recruiting at 2 sites Qianfoshan Hospital · Jinan, Shandong and 1 other locations · NCT07530770

• Tezepelumab to reduce maintenance medication in people with severe asthma

  This will test whether people aged 12–80 with severe asthma in China who start tezepelumab can safely reduce their regular maintenance medicines while keeping asthma controlled.

  Recruiting at 59 sites Phase 3 AstraZeneca · Beijing and 74 other locations · NCT07363642

• GB-0895 as an add-on treatment for severe uncontrolled asthma in adolescents and adults

  This test tries to see if adding GB-0895 every six months helps adolescents and adults whose severe asthma isn't controlled by inhaled steroids and other controllers.

  Recruiting at 158 sites Phase 3 Generate Biomedicines · Bakersfield, California and 157 other locations · NCT07359846

• Remission among Thai adults with severe asthma

  This project will see how common remission is among adults in Thailand with severe asthma and look for links with symptoms, lung function, FeNO, and blood eosinophils.

  Recruiting Thammasat University · Pathum Thani · NCT07328035

• Bronchial thermoplasty for adults whose severe asthma isn't controlled by biologics

  This trial will test whether bronchial thermoplasty helps adults with severe asthma who keep having exacerbations despite biologic treatments or who cannot take biologics.

  Recruiting Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam and 1 other locations · NCT07292805

• GB-0895 added to usual care for adolescents and adults with severe uncontrolled asthma

  This trial will test whether two subcutaneous doses of GB-0895 given six months apart help teens and adults whose severe asthma remains uncontrolled despite medium-to-high dose inhaled steroids and other controllers.

  Recruiting at 152 sites Phase 3 Generate Biomedicines · Northridge, California and 152 other locations · NCT07276724

• How airway mucus plugs affect ventilation and gas exchange on 129Xe MRI in severe asthma

  This project will use hyperpolarized 129Xe MRI to see if mucus plugs cause local airflow and gas-exchange problems in adults with severe asthma who are starting certain biologic medicines.

  Recruiting Duke University · Durham, North Carolina · NCT07139899

• Evaluating lung function in severe asthma patients with mucus plugs

  This study is testing how mucus plugs in the lungs affect breathing and airflow in people with severe asthma using special imaging techniques.

  Recruiting University of Kansas Medical Center · Kansas City, Kansas · NCT06985225

• Survey on patient experiences with biologic treatments for severe asthma

  This study is trying to learn about how people with severe asthma feel about their biologic treatments by having them fill out an online survey about their experiences.

  Recruiting Royal Devon and Exeter NHS Foundation Trust · Exeter, Devon · NCT06903780

• When to stop dupilumab in severe asthma

  This study tests whether stopping dupilumab in people with well-controlled, long-term severe asthma is as safe as continuing it for 24 months.

  Recruiting at 12 sites Phase 4 University Hospital, Toulouse · Toulouse, CHU de Toulouse and 28 other locations · NCT06818019

• Tezepelumab for adults with severe asthma presenting to the emergency department

  This study tests whether a monthly injection of tezepelumab, given in the emergency department, can reduce return visits for asthma flares in adults with severe asthma.

  Recruiting Phase 4 University of Alberta · Edmonton, Alberta and 1 other locations · NCT06705764

• Understanding the experiences of young adults with severe asthma

  This study is trying to understand the daily challenges and support needs of young adults aged 16-25 with severe asthma to help improve their care and outcomes.

  Recruiting Manchester University NHS Foundation Trust · Manchester, Greater · NCT06681545

• Registry for patients with severe asthma in Italy

  This study is collecting information from people with severe asthma in Italy to see how well their treatments are working and to improve care for them over time.

  Recruiting Società Italiana di Allergologia, Asma e Immunologia Clinica · Rozzano, Milano · NCT06625216

• Observational study of patients with uncontrolled severe asthma in Russia

  This study looks at 5,000 adults in Russia with severe asthma to learn more about their treatment and health outcomes while they continue their usual care.

  Recruiting at 36 sites AstraZeneca · Astrakhan and 39 other locations · NCT06472310

• Observational study on severe asthma patients receiving biological therapy

  This study is tracking patients with severe asthma who are starting a new biological therapy for three years to see how well it works and understand their individual responses.

  Recruiting at 2 sites Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Copenhagen and 1 other locations · NCT06126692

• Predicting response to Benralizumab in severe asthma patients

  This study is testing if a specific blood test can help predict how well people with severe asthma will respond to the medication Benralizumab.

  Recruiting at 15 sites Phase 4 Nantes University Hospital · Aix-en-Provence and 19 other locations · NCT04565483

• Creating a database for patients with immune-mediated inflammatory diseases

  This study is creating a database and biobank for patients with immune-related diseases to see if new information can help improve treatments and understand their conditions better.

  Recruiting University Hospital, Lille · Lille · NCT04334031

• Registry for patients with severe asthma in Canada

  This study is collecting health information from people with severe asthma in Canada to see how they respond to treatments and improve their care over the next five years.

  Recruiting at 9 sites University of British Columbia · Edmonton, Alberta and 11 other locations · NCT04045587

• Register for patients with severe asthma

  This study is creating a registry for people with severe asthma in Switzerland to collect important information that can help improve their treatment and care over the next 15 years.

  Recruiting at 10 sites Cantonal Hospital, Baselland · Liestal, Basel-Landschaft and 9 other locations · NCT03984253

NIH-funded research (15)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Neutrophils' role in severe asthma

  This project looks at how certain white blood cells called neutrophils drive severe asthma in people who do not respond to current treatments.

  NIH research Northwestern University · Chicago, United States · NIH-11387532

• Alternative pathobiology in severe asthma affects more than just the classic allergic pathway

  This Mentored Patient-Oriented Research Career Development Award aims to understand a non-traditional pathway (T1 inflammation) that may drive severe asthma in patients who don’t respond to standard therapies.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11377239

• Nebulized STAT3 inhibitor for severe asthma in adults and children

  A new inhaled therapy aims to calm overactive airway inflammation in people with severe asthma by delivering a STAT3-inhibiting compound directly to lung cells.

  NIH research Mercer University Macon · Macon, United States · NIH-11361259

• Understanding how LIGHT affects severe asthma and airway remodeling

  Scientists are studying how a molecule called LIGHT drives severe asthma by promoting dangerous changes in the airways, with the goal of finding new ways to help people who don’t respond to current treatments.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11360603

• How airway lining cells and immune cells drive severe steroid-resistant asthma

  This project looks at how immune cells and the cells that line the airways interact in people whose severe asthma does not respond to corticosteroids, to find clearer markers and better treatment options.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11330457

• Immune and cell‑aging changes in steroid‑resistant severe asthma

  This project looks at immune system changes and early cell aging in people whose severe asthma doesn't improve with steroid treatment to find new treatment ideas.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11292422

• Airway inflammation and scarring in severe asthma

  This project looks at what causes the airways to thicken and scar in people with severe asthma to help find better treatments.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11134396

• Understanding and Treating Severe Asthma Airway Changes

  This research looks at a specific protein called LIGHT to understand how it contributes to severe asthma and to find new ways to help patients.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11078257

• Understanding immune system changes in severe asthma that doesn't respond to corticosteroids

  This study is looking at why some people with severe asthma don’t get better with regular treatments, and it’s for patients who want to help us understand their condition better by sharing their samples and information, which could lead to new ways to treat asthma.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11017767

• Understanding how biologic treatments affect severe asthma in minority patients

  This study is looking at how well biologic treatments work for people with severe asthma, especially focusing on African-American and Puerto Rican patients, to better understand their thoughts and experiences with these therapies.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-10996196

• Understanding different types of severe asthma and how they progress

  This study is looking at the different biological reasons why some adults have severe asthma, so we can better understand the different types of asthma and how they affect people, which will help us find better treatments for you.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-10896787

• Exploring a new cause of severe asthma

  This study is looking at how a specific type of inflammation affects people with severe asthma who don't get better with usual treatments, and it aims to find new ways to help them by examining their immune responses and biological markers over time.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10896314

• Using advanced MRI to improve asthma treatment outcomes with mepolizumab

  This study is looking at a special type of MRI to see how well the asthma treatment mepolizumab works for different people, hoping to find better ways to personalize asthma care and improve treatment outcomes.

  NIH research University of Missouri-Columbia · Columbia, United States · NIH-10891494

• Understanding different types of severe asthma and how they progress

  This study is looking at different types of severe asthma to understand how they work in the body, so we can find better treatments for people with this condition. If you have severe asthma, your participation could help us learn more about your specific needs and improve care for everyone with this condition.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-10684256

• How changes in mucin proteins affect asthma and lung cell aging

  This study is looking at how changes in a protein called mucin on the cells in your airways might make asthma symptoms worse and affect how well your lungs can heal, with the hope of finding new ways to help manage asthma better.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10664889

Related topics

Quick answers

How many Severe Asthma clinical trials are recruiting right now?

22, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 45 countries. The most sites are in United States (5 trials), France (4 trials), United Kingdom (4 trials), Netherlands (3 trials), India (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 3, Phase 4: 3, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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