Understanding different types of severe asthma and how they progress
Official title: Immunometabolic phenotypes in adult severe asthma and disease progression
Funded at Brigham and Women's Hospital · NIH-10896787 · Data updated 2026-11-12
This study is looking at the different biological reasons why some adults have severe asthma, so we can better understand the different types of asthma and how they affect people, which will help us find better treatments for you.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 23, 2019 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $216,239 |
| NIH project number | 3U01HL146002-05S1 |
| Project ID | NIH-10896787 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who have been diagnosed with severe asthma.
✕Less likely to help
Patients with mild asthma or those who do not meet the criteria for severe asthma may not benefit from this research.
What this research studies
This research investigates the various biological mechanisms behind severe asthma in adults, focusing on how these mechanisms differ among patients. By conducting extensive immunometabolic phenotyping, the study aims to identify distinct subtypes of severe asthma, including those with persistent type 2 inflammation and those with non-type 2 disease. The approach involves long-term monitoring of patients to understand how these phenotypes relate to disease severity and progression, ultimately informing better treatment strategies. Patients may undergo various assessments to help characterize their specific asthma type and response to therapies.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatments for patients with severe asthma.
How similar studies have gone: Previous research has shown success in identifying distinct asthma phenotypes, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Levy, Bruce D — Brigham and Women's Hospital
- Study coordinator: Levy, Bruce D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.