Evaluating lung function in severe asthma patients with mucus plugs

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study uses xenon MRI to assess the impact of mucus plugs on lung ventilation and gas exchange in patients with severe asthma. Mucus plugs will be identified through CT imaging, and the study aims to evaluate the regional functional consequences of these plugs on lung function. Participants will undergo imaging to determine how these obstructions affect airflow and overall respiratory health.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adequate completion of informed consent process with written documentation
* Patients 18 - 65 years old
* • Physician diagnosis of muco-obstructive pulmonary disease, including cystic fibrosis, severe asthma, chronic obstructive pulmonary disease, or non-cystic fibrosis bronchiectasis for \> 1 year
* Able to perform reproducible spirometry according to ATS criteria based on clinical PFTs.

Exclusion Criteria:

* Respiratory tract infection within the 4 weeks prior to Visit 1
* Body mass index (BMI) \> 30 at Visit 1
* One-time doses such as intra-articular injections require a 4-week washout prior to Visit 1
* ER visit related to pulmonary condition within the previous 4 weeks of Visit 1
* Significant concomitant medical illness, including (but not limited to) heart disease, cancer, uncontrolled diabetes, other chronic lung diseases (determined by the Investigator.)
* Resting O2 saturation \<90% with maximum supplemental O2 delivered by nasal canula
* Positive urine pregnancy test
* Participation in an intervention study (including bronchoscopy) or use of investigative drugs within the past 30 days or plans to enroll in such a trial during the study
* Unable or unlikely to complete study assessments in the opinion of the Investigator
* Study intervention poses undue risk to patient in the opinion of the Investigator
* Conditions that will prohibit MRI scanning determined by the MRI safety screening.

Where it's running

• University of Kansas Medical Center
  Kansas City, Kansas, United States Recruiting

Study contacts

• Study coordinator: Cristal Monge
• Email: chernandez@kumc.edu
• Phone: (913) 945-9399

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.