Understanding immune system changes in severe asthma that doesn't respond to corticosteroids
Official title: Dysregulated Immunometabolism and Premature Senescence in Corticosteroid-Refractory Severe Asthma
Funded at University of Pittsburgh at Pittsburgh · NIH-11017767 · Data updated 2026-11-12
This study is looking at why some people with severe asthma don’t get better with regular treatments, and it’s for patients who want to help us understand their condition better by sharing their samples and information, which could lead to new ways to treat asthma.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | February 1, 2023 |
| Project end | January 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $666,208 |
| NIH project number | 5R35HL166219-03 |
| Project ID | NIH-11017767 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with severe asthma who do not respond well to corticosteroid treatments.
✕Less likely to help
Patients with mild asthma or those who respond well to corticosteroid treatments may not benefit from this research.
What this research studies
This research investigates the immune mechanisms behind severe asthma that does not respond to standard corticosteroid treatments. By analyzing immune cells from patients and using advanced laboratory models, the study aims to identify specific immune responses that contribute to this condition. The researchers are particularly focused on a subset of patients showing a strong immune response that may require different therapeutic strategies. Patients may have the opportunity to contribute to this research by providing samples and data that could lead to new treatment options.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with severe asthma who currently have limited options.
How similar studies have gone: Other research has shown promising results in understanding immune responses in severe asthma, suggesting that this approach may lead to significant advancements.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Ray, Anuradha — University of Pittsburgh at Pittsburgh
- Study coordinator: Ray, Anuradha
Related research
Other NIH-funded projects on the same topics.
-
Immune and cell‑aging changes in steroid‑resistant severe asthma
This project looks at immune system changes and early cell aging in people whose severe asthma doesn't improve with steroid treatment to find new treatment ideas.
-
Neutrophils' role in severe asthma
This project looks at how certain white blood cells called neutrophils drive severe asthma in people who do not respond to current treatments.
-
Alternative pathobiology in severe asthma affects more than just the classic allergic pathway
This Mentored Patient-Oriented Research Career Development Award aims to understand a non-traditional pathway (T1 inflammation) that may drive severe asthma in patients who don’t respond to standard therapies.
-
Nebulized STAT3 inhibitor for severe asthma in adults and children
A new inhaled therapy aims to calm overactive airway inflammation in people with severe asthma by delivering a STAT3-inhibiting compound directly to lung cells.
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Understanding how LIGHT affects severe asthma and airway remodeling
Scientists are studying how a molecule called LIGHT drives severe asthma by promoting dangerous changes in the airways, with the goal of finding new ways to help people who don’t respond to current treatments.
-
How airway lining cells and immune cells drive severe steroid-resistant asthma
This project looks at how immune cells and the cells that line the airways interact in people whose severe asthma does not respond to corticosteroids, to find clearer markers and better treatment options.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.