Understanding immune system changes in severe asthma that doesn't respond to corticosteroids
Dysregulated Immunometabolism and Premature Senescence in Corticosteroid-Refractory Severe Asthma
This study is looking at why some people with severe asthma don’t get better with regular treatments, and it’s for patients who want to help us understand their condition better by sharing their samples and information, which could lead to new ways to treat asthma.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11017767 on NIH RePORTER |
What this research studies
This research investigates the immune mechanisms behind severe asthma that does not respond to standard corticosteroid treatments. By analyzing immune cells from patients and using advanced laboratory models, the study aims to identify specific immune responses that contribute to this condition. The researchers are particularly focused on a subset of patients showing a strong immune response that may require different therapeutic strategies. Patients may have the opportunity to contribute to this research by providing samples and data that could lead to new treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with severe asthma who do not respond well to corticosteroid treatments.
Not a fit: Patients with mild asthma or those who respond well to corticosteroid treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with severe asthma who currently have limited options.
How similar studies have performed: Other research has shown promising results in understanding immune responses in severe asthma, suggesting that this approach may lead to significant advancements.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Ray, Anuradha — University of Pittsburgh at Pittsburgh
- Study coordinator: Ray, Anuradha
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.