Understanding different types of severe asthma and how they progress
Official title: Immunometabolic phenotypes in adult severe asthma and disease progression
Funded at Brigham and Women's Hospital · NIH-10684256 · Data updated 2026-11-12
This study is looking at different types of severe asthma to understand how they work in the body, so we can find better treatments for people with this condition. If you have severe asthma, your participation could help us learn more about your specific needs and improve care for everyone with this condition.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 23, 2019 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $3,233,979 |
| NIH project number | 5U01HL146002-05 |
| Project ID | NIH-10684256 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who have been diagnosed with severe asthma.
✕Less likely to help
Patients with mild asthma or those who do not meet the criteria for severe asthma may not benefit from this research.
What this research studies
This research investigates the various biological mechanisms behind severe asthma by conducting extensive assessments over time. It aims to identify distinct phenotypes of severe asthma patients, focusing on those with persistent type 2 inflammation and those with non-type 2 disease. By analyzing these differences, the study seeks to improve therapeutic strategies and clinical management for patients suffering from severe asthma. Participants will undergo comprehensive immunometabolic phenotyping to better understand their specific condition and treatment needs.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatments for patients with severe asthma.
How similar studies have gone: Previous research has shown success in identifying distinct asthma phenotypes, indicating that this approach has potential for meaningful advancements.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Levy, Bruce D — Brigham and Women's Hospital
- Study coordinator: Levy, Bruce D
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This project looks at how immune cells and the cells that line the airways interact in people whose severe asthma does not respond to corticosteroids, to find clearer markers and better treatment options.
-
Immune and cell‑aging changes in steroid‑resistant severe asthma
This project looks at immune system changes and early cell aging in people whose severe asthma doesn't improve with steroid treatment to find new treatment ideas.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.