NIH-funded research NIH-funded research

Understanding how biologic treatments affect severe asthma in minority patients

Official title: Synthesizing Trial and Real-world Data on the Use of Biologics in Patients with Severe Asthma

Funded at Brigham and Women's Hospital · NIH-10996196 · Data updated 2026-11-12

This study is looking at how well biologic treatments work for people with severe asthma, especially focusing on African-American and Puerto Rican patients, to better understand their thoughts and experiences with these therapies.

More Asthma research and trials

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionBrigham and Women's Hospital
NIH-funded
Lab location1 site (Boston, United States)
Project startDecember 26, 2020
Project endDecember 31, 2025
Funding year2025
Award (this year)$179,279
NIH project number5R00MD015767-05
Project IDNIH-10996196 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are individuals with severe asthma, particularly those who identify as African-American or Puerto Rican.

Less likely to help

Patients with mild asthma or those who do not belong to the targeted minority groups may not benefit from this research.

What this research studies

This research investigates the use of biologic therapies in patients with severe asthma, particularly focusing on African-American and Puerto Rican populations who experience higher rates of asthma-related issues. The study aims to gather real-world data and patient perspectives on biologics, exploring their attitudes and beliefs about these treatments. By employing mixed methods and analyzing various patient and provider factors, the research seeks to understand how these elements influence the effectiveness and utilization of biologics in these communities.

Why it matters

Potential benefit: If successful, this research could lead to improved asthma treatment strategies that are more effective for minority patients.

How similar studies have gone: Previous research has shown that addressing disparities in treatment can lead to improved health outcomes, suggesting that this approach has potential for success.

Where this research is happening

  • Brigham and Women's Hospital
    Boston, United States
    Active

Researchers

  • Principal investigator: Akenroye, Ayobami T — Brigham and Women's Hospital
  • Study coordinator: Akenroye, Ayobami T

Related research

Other NIH-funded projects on the same topics.

  • Neutrophils' role in severe asthma

    This project looks at how certain white blood cells called neutrophils drive severe asthma in people who do not respond to current treatments.

    NIH research Northwestern University · Chicago, United States · NIH-11387532

  • Alternative pathobiology in severe asthma affects more than just the classic allergic pathway

    This Mentored Patient-Oriented Research Career Development Award aims to understand a non-traditional pathway (T1 inflammation) that may drive severe asthma in patients who don’t respond to standard therapies.

    NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11377239

  • Nebulized STAT3 inhibitor for severe asthma in adults and children

    A new inhaled therapy aims to calm overactive airway inflammation in people with severe asthma by delivering a STAT3-inhibiting compound directly to lung cells.

    NIH research Mercer University Macon · Macon, United States · NIH-11361259

  • Understanding how LIGHT affects severe asthma and airway remodeling

    Scientists are studying how a molecule called LIGHT drives severe asthma by promoting dangerous changes in the airways, with the goal of finding new ways to help people who don’t respond to current treatments.

    NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11360603

  • How airway lining cells and immune cells drive severe steroid-resistant asthma

    This project looks at how immune cells and the cells that line the airways interact in people whose severe asthma does not respond to corticosteroids, to find clearer markers and better treatment options.

    NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11330457

  • Immune and cell‑aging changes in steroid‑resistant severe asthma

    This project looks at immune system changes and early cell aging in people whose severe asthma doesn't improve with steroid treatment to find new treatment ideas.

    NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11292422

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.