99mTc-CTR-FAPI SPECT imaging to detect inflamed joints in rheumatoid arthritis
Official title: Research on the Application of 99mTc-TCR-FAPI SPECT Imaging in Rheumatoid Arthritis
Run by Peking Union Medical College Hospital · NCT07138729 · Data updated 2026-11-12
This trial will test whether 99mTc-CTR-FAPI SPECT scans can detect active joint inflammation as well as 68Ga-FAPI PET/CT in adults with moderate-to-high rheumatoid arthritis.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 75 Years |
| Sex | All |
| Enrollment | 20 (estimated) |
| Sponsor | Peking Union Medical College Hospital Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Status | Recruiting |
| Started | May 10, 2025 |
| Main results expected | December 1, 2027 |
| Study ends | April 28, 2028 |
| Registry record updated | August 24, 2025 |
| Trial ID | NCT07138729 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–75 who meet the 2010 ACR/EULAR RA criteria and have moderate-to-high disease activity, and who can undergo nuclear imaging without contraindications, are suitable candidates.
✕Probably not a fit
Patients who are pregnant or breastfeeding, have other autoimmune diseases, concurrent cancer, active infection, severe claustrophobia, or who have low disease activity are unlikely to benefit from this imaging comparison.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Twenty adults with rheumatoid arthritis and moderate-to-high disease activity will undergo both 99mTc-CTR-FAPI SPECT and 68Ga-FAPI PET/CT for direct, head-to-head comparison. Scans will be read independently by two nuclear medicine physicians with ≥10 years' experience, and a joint-by-joint comparison will be made between the two imaging methods. Imaging findings will be compared with tender and swollen joint counts from physical examination and correlated with clinical disease activity scores (CDAI/SDAI). The goal is to determine if the 99mTc SPECT approach provides consistent diagnostic information while offering lower cost and radiation exposure.
Why it matters
Potential benefit: If successful, this could offer a lower-cost, lower-radiation imaging option to monitor joint inflammation and guide long-term RA care.
How similar studies have gone: 68Ga-FAPI PET/CT has shown promise for imaging synovitis in prior reports, but using a 99mTc-labeled FAPI agent with SPECT is a newer approach with limited prior validation.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age: 18-75 years old; 2. Meet the classification criteria for rheumatoid arthritis of the American College of Rheumatology/European Union for Rheumatology in 2010; 3. The highest disease activity in clinical practice (CDAI or SDAI score Exclusion Criteria: 1. Patients with other autoimmune diseases; 2. Patients with concurrent tumors; 3. Women who are pregnant or planning to become pregnant, women in the preconception period, pregnant and lactating women, and women with child-rearing plans during the study period; Subjects of childbearing age need to take effective contraceptive measures during the research process; 4. Active infection 5. Suffering from claustrophobia or other mental disorders, with poor compliance resulting in inability to cooperate with this researcher; (6) Situations where other researchers consider it inappropriate to participate in this clinical trial.
Where it's running
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Peking Union Medical College Hospital
Beijing, Beijing Municipality, China Recruiting
Study contacts
- Principal investigator: Yaping LUO — Peking Union Medical College Hospital
- Study coordinator: Yaping Luo, MD
- Email: luoyaping@live.com
- Phone: 86-010-69154716
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.