Evaluating the effects of oral AP1189 in early rheumatoid arthritis patients

A Randomized, Double Blind, Placebo-controlled, Dose Response, Phase II, Multicentre Trial to Evaluate the Efficacy and Safety of Oral AP1189 Administered at the Doses of 40, 70, or 100 mg for 12 Weeks in Combination With Methotrexate, in DMARD-naïve Participants With Early Rheumatoid Arthritis and Active Inflammation.

This study is testing if a new oral medication called AP1189 can help people with early rheumatoid arthritis feel better when taken with methotrexate.

Quick facts

• Phase: Phase 2
• Study type: Interventional
• Enrollment: 240 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: SynAct Pharma Aps (Industry-sponsored)
• Drugs / interventions: methotrexate
• Locations: 11 sites (Cutler Bay, Florida and 10 other locations)
• Trial ID: NCT06671054 on ClinicalTrials.gov

What this trial studies

This clinical trial is a randomized, double-blind, placebo-controlled, phase II study designed to assess the efficacy and safety of oral AP1189 at doses of 40, 70, or 100 mg, administered daily for 12 weeks in combination with methotrexate. The study will involve 240 participants who are DMARD-naïve and have early rheumatoid arthritis with active inflammation. Participants will be randomized into four groups to receive either AP1189 or a matching placebo alongside methotrexate, allowing for a comprehensive evaluation of the treatment's effects.

Who should consider this trial

Good fit: Ideal candidates are individuals diagnosed with early rheumatoid arthritis who have not previously received DMARD therapy.

Not a fit: Patients with a history of treatment with DMARDs or those with a disease duration exceeding 6 months may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment could provide a new effective option for managing early rheumatoid arthritis.

How similar studies have performed: Other studies have shown promise in evaluating similar approaches for treating rheumatoid arthritis, but this specific combination is novel.

Eligibility criteria

Inclusion Criteria:

* Signed and dated informed consent obtained before undergoing any trial-specific procedure.
* Participants with definite RA diagnosis according to the 2010 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) classification criteria.
* Disease duration no longer than 6 months from diagnosis at the time of Baseline Visit and with a history of RA symptoms which does not exceed 18 months.
* Participants must be naïve to any Disease-modifying anti-rheumatic drugs (DMARDs)
* Participants with at least 6/68 tender and 6/66 swollen joints at Screening Visit and Baseline.
* Participants with "high" disease activity as documented by a Disease Activity Score 28 (DAS28) (C-Reactive Protein - CRP) index score \> 5.1 at screening, and Clinical disease activity index (CDAI) \>22 at Screening Visit and Baseline.
* Participants with serum high sensitive C-Reactive Protein (hsCRP) ≥3 mg/L at the time of screening.
* Participants positive for serum rheumatoid factor (RF), AND/OR anti-cyclic citrullinated peptide antibodies (anti-CCP). If seronegative RA, hsCRP ≥6 mg/L at the time of screening.
* Willing and able to comply with the scheduled study visits, the treatment plan, and all study procedures.
* Females of childbearing potential must have a negative pregnancy test at screening and again at baseline.
* Sexually active female participants of childbearing potential and male participants are excluded if not practicing two different methods of birth control with their partner during the study and for 90 days after the last dose of study drug or who will not remain abstinent during the study and for 90 days after the last dose.

Exclusion Criteria:

* Functional class IV of Global Functional Status in RA, as defined by the ACR Classification.
* Rheumatic autoimmune disease other than RA, i.e. systemic lupus erythematosus, mixed connective tissue disease, scleroderma, polymyositis, or significant systemic involvement secondary to RA.
* Current inflammatory joint disease other than RA.
* Non-inflammatory type of musculoskeletal condition that in the Investigator's opinion is symptomatic and/or severe enough to interfere with the subject's primary diagnosis of RA or the evaluation of the effect of the study drug.
* Gastrointestinal diseases known to interfere with the absorption or excretion of medications.
* Severe, progressive, or uncontrolled renal, hepatic, hematologic, gastrointestinal, metabolic, endocrine, pulmonary, cardiac or neurologic disease.
* Malignancy active during the 12 months preceding the Screening Visit.
* Acute hepatitis, chronic hepatitis, or detection of any unexplained elevation of serum ALT or AST greater than 1.5-fold ULN, at least twice in the 6 months before the Screening Visit) or HIV infection.
* History of alcohol or drug abuse during the 12 months preceding the Screening Visit.
* Vaccination with live vaccines during the 6 weeks preceding the Screening Visit.
* Haemoglobin \<9 g/dL or Haematocrit \<30% at the Screening Visit
* White blood cell (WBC) count \<3.0 x 109/L at the Screening Visit.
* Absolute neutrophil count \<1.2 x 109/L at the Screening Visit.
* Platelet count \<100 x 109/L at the Screening Visit.
* Serum alkaline-phosphatase, or gamma-glutamyl-transferase greater than 3-fold ULN; alanine aminotransferase, or aspartate aminotransferase, or total bilirubin greater than 2-fold ULN At the Screening Visit.
* Estimated creatinine clearance less than 45 mL/min/1.73 m2 (MDRD) at the Screening Visit.
* 12-lead electrocardiogram (ECG) with abnormal clinically significant findings, as judged by the Investigator, at the Screening Visit.
* Positive QuantiFERON-in-Tube test (QFG-IT).
* Use of hydroxychloroquine during the 30 weeks preceding the Screening Visit.
* Treatment with any systemic or intraarticular corticosteroid within 6 weeks before the Screening Visit.
* Intermittent use of nonsteroidal anti-inflammatory drugs (NSAIDs). Use of NSAIDs is allowed if used in a stable dose regimen for at least 4 weeks prior to the Screening Visit.
* Use of other investigational drugs/treatments, or enrolment in a clinical trial during the 6 months preceding the Screening Visit.
* Any other clinically relevant disease and condition that, in the opinion of the Investigator, may jeopardize efficacy or safety assessments or may compromise the subject's safety during trial participation.

Where this trial is running

Cutler Bay, Florida and 10 other locations

• Nouvelle Clinical Research LLC — Cutler Bay, Florida, United States (Recruiting)
• Millennium Medical Research LLC — Miami, Florida, United States (Recruiting)
• Altoona Center for Clinical Research — Duncansville, Pennsylvania, United States (Recruiting)
• Diagnostic Consultative Center Aleksandrovska — Sofia, Bulgaria (Recruiting)
• Medical Center Tera Medico — Vratsa, Bulgaria (Recruiting)
• Sanos Clinic Herlev — Herlev, Denmark (Recruiting)
• IMSP Spitalul Clinic Municipal "Sfanta Treime" — Chisinau, Moldova (Recruiting)
• M2Mmed — Chorzów, Poland (Recruiting)
• Vita Longa Sp. z o. o. — Katowice, Poland (Recruiting)
• Medyczne Centrum Hetmańska — Poznan, Poland (Recruiting)
• DC-MED Michal Kowalski S.K. — Swidnica, Poland (Recruiting)

Study contacts

• Study coordinator: Thomas Jonassen, MD

Conditions Rheumatoid Arthritis