100% plant-based diet for adults with rheumatoid arthritis
Official title: PLATE: Health Effects of Plant-Based Diet in Patients With Rheumatoid Arthritis
Run by Center for Clinical Research and Prevention · NCT07268326 · Data updated 2026-11-12
This trial will test whether following a 100% plant-based diet for 16 weeks helps adults with rheumatoid arthritis lower disease activity, reduce symptoms, and improve quality of life.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 180 (estimated) |
| Sponsor | Center for Clinical Research and Prevention Research network |
| Locations | 2 sites (Frederiksberg and 1 other locations) |
| Status | Recruiting |
| Started | December 15, 2025 |
| Main results expected | December 2028 |
| Study ends | December 2028 |
| Registry record updated | March 18, 2026 |
| Trial ID | NCT07268326 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (≥18) with a physician-diagnosed RA for at least one year, low disease activity (DAS28 ≤3.2) without swollen joints, and on stable RA medication would be ideal candidates, provided they are not smokers, not diabetic, not pregnant, and not already following a plant-based diet.
✕Probably not a fit
Patients with higher disease activity (DAS28 >3.2), current prednisolone treatment, diabetes, pregnancy or planned pregnancy, smokers, those already on a plant-based diet, or with relevant food allergies/intolerances are unlikely to qualify or to gain benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized controlled trial compares a 16-week 100% plant-based diet (PBD) intervention to participants' habitual diet in adults with rheumatoid arthritis. The intervention group receives weekly food box deliveries, a daily multivitamin, continuous dietetic guidance, a practical cooking class, and three online supervision sessions, while the control group continues their usual diet with the same visit schedule. Primary outcomes include change in disease activity measured by DAS28, with secondary outcomes covering cardio-metabolic health, physical function, mental health, sleep, and health-related quality of life. Eligible participants are adults with RA for at least one year, low disease activity (DAS28 ≤3.2) without swollen joints, and stable pharmacological treatment prior to enrollment.
Why it matters
Potential benefit: If successful, this could provide a practical dietary approach that lowers RA disease activity and improves symptoms and overall quality of life.
How similar studies have gone: Previous dietary interventions in RA have produced mixed results, and fully 100% plant-based diets have been only sparsely and inconclusively studied to date.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥18 years * DAS28 score ≤3.2, and without swollen joints * RA diagnosis of minimum one year * Stable pharmacological treatment for at least four months and with no planned change in treatment within eight weeks Exclusion Criteria: * Smokers * Diabetes mellitus * Pregnancy / planned pregnancy * Prednisolone treatment * DAS28 above 3.2 * Current dietary habits resembling intervention diet (e.g., PBD lifestyle) * Food allergies and intolerances * Unable to understand the informed consent and study procedures
Where it's running
-
Bispebjerg and Frederiksberg Hospital, Center for Clinical Research and Prevention
Frederiksberg, Denmark Recruiting -
The Department of Rheumatology and Spine Diseases, Copenhagen Center for Arthritis Research (COPECARE), Rigshospitalet, Glostrup
Glostrup Municipality, Denmark Recruiting
Study contacts
- Study coordinator: Nikita Misella Hansen, Postdoc
- Email: nikita.misella.hansen@regionh.dk
- Phone: +4520661876
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.