Condition

Respiratory Insufficiency clinical trials and research

• 21Clinical trials
• 3NIH research projects
• 21Countries

Newest Respiratory Insufficiency clinical trials

All recruiting trials (21)

• Bedside Spirometry to see if tidal volume matches ideal body weight in non-intubated ARDS

  This pilot study tests whether tidal volume measured at bedside with high-flow oxygen and after NIV settings can help classify ARDS patients who are not intubated.

  Recruiting Centre Hospitalier Departemental Vendee · La Roche-sur-Yon and 1 other locations · NCT07750717

• Early breathing therapy just one hour after CABG extubation

  This trial tests whether starting respiratory physiotherapy one hour after extubation improves recovery for adults after elective CABG compared with starting on the first postoperative day.

  Recruiting Alma Mater Europaea - Slovenia · Zagreb · NCT07730034

• Humidification methods in trauma ICU patients on mechanical ventilation

  This study tests whether active heated humidifiers or passive heat-and-moisture exchangers work better in trauma ICU patients who need long-term mechanical ventilation.

  Recruiting Assiut University · Asyut, Asyut Governorate · NCT07713238

• Turkish version of the S3-NIV questionnaire: testing its reliability for home NIV patients

  We’re testing whether the Turkish S3-NIV questionnaire reliably measures how well patients on home non-invasive ventilation can manage daily use and comfort.

  Recruiting Istanbul Saglik Bilimleri University · Istanbul · NCT07610122

• Compliance-guided Closure Strategy for Large Ventral Hernia Repair

  This study tests whether using a structured intraoperative plan based on respiratory system stiffness helps decide how to close the abdominal wall in people with large ventral hernias.

  Recruiting Swissmed Hospital · Gdansk · NCT07422441

• Impact of Low vs High PEEP on Diaphragm and Lung Function in Mechanically Ventilated Patients

  This study tests whether different levels of PEEP (low, medium, high) change diaphragm effort and ventilation effectiveness in adults on pressure-support ventilation in the ICU.

  Recruiting Vastra Gotaland Region · Gothenburg, Västra Götaland County and 1 other locations · NCT07188038

• Early Non-Invasive Ventilation in ALS

  This study tests whether starting non-invasive ventilation earlier in adults with ALS can help improve breathing and quality of life.

  Recruiting at 3 sites Phase 2 University of Pennsylvania · Hershey, Pennsylvania and 2 other locations · NCT07071935

• Comparing home and hospital care for non-invasive ventilation in motor neurone disease

  This study is testing whether using non-invasive ventilation at home can help people with Motor Neurone Disease breathe better and live more comfortably compared to getting treatment in the hospital.

  Recruiting Papworth Hospital NHS Foundation Trust · Cambridge · NCT06844370

• Using a special bed to reduce pressure injuries in critically ill patients

  This study is testing if a special bed can help prevent pressure injuries in critically ill adults and elderly patients on ventilators better than regular repositioning methods.

  Recruiting University of Sao Paulo General Hospital · São Paulo, São Paulo · NCT06819943

• Evaluating respiratory functions and exercise capacity in children with neuromuscular diseases

  This study is trying to see how well children with Duchenne Muscular Dystrophy and Spinal Muscular Atrophy can breathe and exercise compared to healthy kids.

  Recruiting Lokman Hekim University · Ankara, Çankaya · NCT06756633

• Continuing oral intake versus fasting for adults with acute respiratory failure

  This trial tests if letting adults in the ICU with acute respiratory failure continue oral intake is as safe as keeping them fasting.

  Recruiting at 13 sites University Hospital, Tours · Blois and 13 other locations · NCT06510972

• Testing different facemasks for noninvasive ventilation in respiratory failure

  This study tests which of three different facemasks works best for helping people with severe breathing problems get rid of carbon dioxide.

  Recruiting at 2 sites Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Roma and 1 other locations · NCT06483984

• Comparing blood thinners for patients on ECMO support

  This study is testing whether two different blood thinners, argatroban and enoxaparin, can work as well as the usual treatment, heparin, for patients on ECMO support.

  Recruiting Phase 4 Medical University of Vienna · Vienna, State of Vienna · NCT06442267

• Decision-making support for families considering home ventilation for children

  This study is testing a new website to help families and doctors make better decisions about home ventilation for children with chronic breathing issues.

  Recruiting at 4 sites Johns Hopkins University · Tampa, Florida and 3 other locations · NCT06102330

• Breathing and swallowing training for people with ALS

  This study is testing if breathing and swallowing training can help people with ALS breathe better and improve their quality of life.

  Recruiting Nova Southeastern University · Fort Lauderdale, Florida · NCT05913882

• Using diaphragm ultrasound to predict respiratory complications after surgery

  This study is testing if using ultrasound to check diaphragm function can help predict breathing problems after major surgeries.

  Recruiting at 2 sites Karolinska University Hospital · Stockholm, Stockholm County and 1 other locations · NCT05906030

• Reducing respiratory drive using a novel gas flow system

  This study tests a new gas flow system to see if it can help patients on mechanical ventilation breathe better and avoid lung injuries.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT05642832

• Evaluating new treatments for acute respiratory failure

  This study is testing new treatments for patients with severe breathing problems to see if different ventilation methods can help them survive better in the hospital.

  Recruiting at 100 sites University Health Network, Toronto · Tucson, Arizona and 102 other locations · NCT05440851

• Tracking chest and abdominal motion to detect breathing mismatch in children

  This project will test whether small motion sensors placed on a child's chest and belly can detect mismatched breathing (thoracoabdominal asynchrony) to help guide when to start, change, or stop breathing support.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT04626154

• Partial neuromuscular blockade to enable safe spontaneous breathing in acute hypoxemic respiratory failure

  This tests whether a low-dose infusion of the muscle-paralyzing drug cisatracurium can let people with moderate to severe low-oxygen respiratory failure on mechanical ventilation or venovenous ECMO breathe safely on their own while protecting their lungs.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT04524585

• Doxapram treatment for preterm infants with breathing issues

  This study is testing if doxapram can help preterm infants with breathing problems avoid serious complications and reduce the need for breathing machines.

  Recruiting at 18 sites Phase 3 Erasmus Medical Center · Brussels, Avenaue Hippocrate 10 and 23 other locations · NCT04430790

NIH-funded research (3)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Optimizing gene therapy to help breathing in Duchenne muscular dystrophy

  A Duke University team is testing a gene therapy approach to improve breathing in boys with Duchenne muscular dystrophy.

  NIH research Duke University · Durham, United States · NIH-11372247

• Improving Gene Therapy for Breathing Problems in Duchenne Muscular Dystrophy

  This research aims to make gene therapy better at helping children with Duchenne muscular dystrophy breathe more easily.

  NIH research Duke University · Durham, United States · NIH-11145834

• Improving gene therapy for breathing problems in Duchenne muscular dystrophy

  This study is looking at a new gene therapy to help improve breathing and muscle health for people with Duchenne muscular dystrophy (DMD) by using a special virus to deliver a helpful gene, and it's being tested in mouse models that mimic human conditions.

  NIH research Duke University · Durham, United States · NIH-10980431

Related topics

Quick answers

How many Respiratory Insufficiency clinical trials are recruiting right now?

21, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 21 countries. The most sites are in United States (5 trials), Canada (4 trials), Italy (2 trials), Turkey (Türkiye) (2 trials), Sweden (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 1, Phase 3: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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