Early breathing therapy just one hour after CABG extubation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults undergoing elective CABG are randomized to receive respiratory physiotherapy either one hour after extubation or starting the following postoperative day. The study aims to see if earlier therapy improves lung function, reduces lung-related complications, shortens ICU and hospital stays, and eases pain and anxiety. It uses standardized physiotherapy procedures and perioperative care to ensure consistent assessment. Conducted at University Hospital Centre Zagreb, the trial follows good clinical practice and ethical guidelines.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults aged 18-80 years
* Male and female participants
* Elective coronary artery bypass grafting (CABG)
* Body mass index (BMI) \< 30 kg/m²
* Left ventricular ejection fraction (EF) \> 25%
* Extubated on postoperative day 0 (POD 0)
* Able and willing to provide written informed consent
* Able to perform spirometry and follow study instructions

Exclusion Criteria:

* Refusal or inability to provide informed consent
* Emergency CABG surgery
* Previous cardiac surgery
* Severe cardiac arrhythmias (e.g., ventricular tachycardia/fibrillation, third-degree atrioventricular block)
* Previous stroke
* Motor impairment of upper or lower extremities due to neurological or musculoskeletal disease
* Dyskinesia
* Not extubated on POD 0
* Significant postoperative neurological complications
* Peripheral arterial disease of the lower extremities or previous lower-limb amputation
* Acute or chronic pulmonary disease
* Preoperative FEV1 \<30% of predicted (greater than 70% reduction)
* Inability to perform spirometry correctly
* Cancelled surgery after preoperative assessment
* Extubation later than 24 hours after surgery
* Requirement for continuous positive airway pressure (CPAP) after extubation SpO₂ \<90% one hour after extubation despite oxygen supplementation (4 L/min by nasal cannula)
* Return to the operating room after the initial CABG procedure
* Requirement for dialysis (acute or chronic)

Where it's running

• University Hospital Centre Zagreb
  Zagreb, Croatia Recruiting

Study contacts

• Principal investigator: Dijana Filipović, MSc — Clinical Hospital Centre Zagreb
• Study coordinator: Dijana Filipović, MSc
• Email: dijana.filipovic@kbc-zagreb.hr
• Phone: +385 99 4663124

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Bedside Spirometry to see if tidal volume matches ideal body weight in non-intubated ARDS

  This pilot study tests whether tidal volume measured at bedside with high-flow oxygen and after NIV settings can help classify ARDS patients who are not intubated.

  Recruiting Centre Hospitalier Departemental Vendee · La Roche-sur-Yon and 1 other locations · NCT07750717

• Nonintubated anesthesia for adults undergoing cardiac surgery with bypass

  This trial tests a nonintubated airway approach with the goal of seeing if avoiding endotracheal intubation during elective valve or bypass surgery can reduce lung problems and help patients recover faster.

  Recruiting The First Affiliated Hospital of Guangzhou Medical University · Guangzhou, Guangdong · NCT07744009

• Structured inpatient physiotherapy before and after CABG for high-risk patients

  This trial tests whether starting a structured inpatient physiotherapy program at least two days before CABG and continuing after surgery helps high-risk patients recover faster than the same program used only after surgery.

  Recruiting Bezmialem Vakif University · Istanbul, Eyupsultan · NCT07725887

• Humidification methods in trauma ICU patients on mechanical ventilation

  This study tests whether active heated humidifiers or passive heat-and-moisture exchangers work better in trauma ICU patients who need long-term mechanical ventilation.

  Recruiting Assiut University · Asyut, Asyut Governorate · NCT07713238

• Timing of Recruitment Maneuver in Robotic Prostate Surgery

  This study tests whether doing a recruitment maneuver before or after CO2 insufflation during robotic prostate surgery helps prevent lung problems afterward.

  Recruiting Ankara University · Ankara · NCT07662642

• Del Nido vs Blood Cardioplegia for Heart Muscle Health During CABG

  This study tests whether Del Nido cardioplegia helps preserve heart muscle better than standard blood cardioplegia in people undergoing coronary artery bypass grafting.

  Recruiting at 2 sites Klinički Bolnički Centar Zagreb · Zagreb and 1 other locations · NCT07637266

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.