Understanding How Priors Influence Hallucinations in Parkinson’s

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study compares Parkinson’s patients with and without visual hallucinations, plus healthy controls, to see if prior expectations affect false perceptions during a face-detection task. Participants complete a computer-based stimulus-detection exercise and a set of neuropsychological tests to explore perceptual processing and cognitive factors. The goal is to identify mechanisms behind hallucinations in Parkinson’s and how expectations shape perception in everyday life. Results may highlight targets for interventions to reduce hallucinations and improve daily functioning.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults diagnosed with Parkinson's disease (with or without visual hallucinations) or healthy volunteers.
* Age 18 - 85 years.
* Consent to participate.

Exclusion Criteria:

* Currently participating in another clinical or therapeutic trial involving the testing of a drug treatment.
* Inability to perform cognitive tests due to:

Non-psychiatric (somatic) conditions likely to affect cognitive abilities. Peripheral sensory or motor deficits. Acute clinical conditions (e.g., agitation, impaired consciousness).

* Diagnosis of dementia.
* Individuals covered by Articles L1121-5 to L1121-8 of the French Public Health Code (Code de la Santé Publique), including:

Pregnant women, women in labor, or breastfeeding mothers. Individuals deprived of liberty by judicial or administrative decision. Individuals receiving psychiatric care under Articles L. 3212-1 and L. 3213-1 (excluding those covered by Article L. 1121-8).

Individuals admitted to a healthcare or social institution for purposes other than research.

Minors or adults under legal guardianship or unable to express consent.

\- Individuals with a hierarchical relationship to any professional involved in the study.

Only for healthy volunteers:

\- Personal history of diagnosed neurological disorders.

Post-Inclusion Exclusion:

\- Participants included in the study but found to have a MoCA score below 24 will be excluded from the study.

Where it's running

• CHU Grenoble Alpes
  Grenoble, France Recruiting
• Grenoble University Hospitals
  La Tronche, France Recruiting

Study contacts

• Principal investigator: Anna Castrioto — University Hospital, Grenoble
• Study coordinator: Anna Castrioto, MD, PhD
• Email: acastrioto@chu-grenoble.fr
• Phone: +33 4 76 76 94 52

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.