Condition

Paralysis clinical trials and research

• 10Clinical trials
• 28NIH research projects
• 3Countries

Newest Paralysis clinical trials

All recruiting trials (10)

• Robotic implantation of a precise brain‑computer interface to restore communication

  This project tests whether a robotically implanted Neuralink N1 brain implant can help adults with severe, irreversible speech loss from ALS, spinal cord injury, or stroke communicate again.

  Recruiting Neuralink Corp · Dallas, Texas · NCT07224256

• Robotically implanted brain-computer interface for patients with severe paralysis

  This study is testing a new brain implant that uses a robot to help people with severe paralysis communicate and control devices better.

  Recruiting at 2 sites Neuralink Corp · Phoenix, Arizona and 1 other locations · NCT06429735

• MindEx multifocal cognitive brain‑machine interface for people with severe paralysis

  This trial will test the MindEx system, which uses four tiny implanted brain chips to let people with severe paralysis control a computer or tablet with their thoughts.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT05936619

• MindEx multifocal cognitive brain‑machine interface for people with severe paralysis

  This trial will test the MindEx system, which uses four tiny implanted brain chips to let people with severe paralysis control a computer or tablet with their thoughts.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT05936619

• Evaluating the Nomad powered KAFO for improving mobility in individuals with lower-extremity impairments

  This study is testing if a new powered brace can help people with leg injuries move better and feel more balanced compared to their regular braces.

  Recruiting Shirley Ryan AbilityLab · Chicago, Illinois · NCT05644522

• Training system to improve spinal reflexes in individuals with spinal cord injuries

  This study is testing a new training system to see if it can help people with spinal cord injuries reduce leg stiffness and improve their movement.

  Recruiting Medical University of South Carolina · Charleston, South Carolina and 1 other locations · NCT05094362

• Using electrical stimulation to improve movement in people with paralysis or weakness

  This study is testing if using electrical stimulation can help people with paralysis or weakness from spinal cord injuries or strokes improve their movement.

  Recruiting Early Phase 1 Northwell Health · Manhasset, New York · NCT04755699

• Detecting awareness in patients with disorders of consciousness

  This study tests if a special brain-monitoring technology can help doctors see if patients with severe consciousness disorders are aware and then teach those who are aware how to communicate.

  Recruiting at 17 sites University of Ulster · Dublin and 17 other locations · NCT03827187

• A device to improve sitting posture and balance for individuals with spinal cord injuries

  This study is testing a new device that helps people with spinal cord injuries sit better and improve their balance by using electrical stimulation to strengthen their muscles.

  Recruiting VA Office of Research and Development · Cleveland, Ohio · NCT01474148

• Evaluation of a neuroprosthesis for improving mobility in paralyzed individuals

  This study is testing a new device that helps people with paralysis improve their movement and balance through a special electrical stimulation system implanted in their muscles.

  Recruiting at 2 sites Case Western Reserve University · Cleveland, Ohio and 1 other locations · NCT00623389

NIH-funded research (28)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Neuromuscular Junction Problems in Hyperkalemic Paralysis

  A clinician-scientist is pursuing five years of advanced training and research to better understand and care for people with neuromuscular diseases related to hyperkalemic paralysis.

  NIH research Wright State University · Dayton, United States · NIH-11393593

• Restoring movement after paralysis with AI-powered copilots

  A patient-facing AI-aided system would help people with paralysis perform everyday tasks by interpreting the user’s intent and guiding assistive robots.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11387866

• CoPE II: Personalizing patient-reported outcomes for vocal fold paralysis care

  Aimed at tailoring patient-reported outcome measures to each person with unilateral vocal fold paralysis to better guide treatment decisions.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11378997

• Mobile brain-computer interface to help veterans with paralysis control devices

  Aimed at improving a mobile brain-computer interface to help veterans with paralysis better control assistive devices at home.

  NIH research Providence VA Medical Center · Providence, United States · NIH-11328988

• Preventing awareness during paralysis in emergency ventilated patients and reducing PTSD

  This project will change emergency department medication defaults to cut back on a paralytic drug and see if that lowers the chance that adults put on ventilators wake up while paralyzed and later develop PTSD.

  NIH research Washington University · Saint Louis, United States · NIH-11325301

• Muscle stem cells to repair paralyzed vocal cords

  This project uses muscle-derived stem cells to rebuild and strengthen paralyzed vocal cords in adults with vocal fold paralysis.

  NIH research Washington University · Saint Louis, United States · NIH-11292852

• Brain-controlled device to restore movement after paralysis

  This project works to turn signals from two brain areas into controls so people with tetraplegia can steer devices or robotic limbs more naturally.

  NIH research California Institute of Technology · Pasadena, United States · NIH-11266028

• CaV1.1-linked hypokalemic periodic paralysis: causes and treatment approaches

  This project studies how CaV1.1 gene mutations cause low‑potassium muscle weakness and explores ways to stop attacks and slow permanent weakness in people with hypokalemic periodic paralysis.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11235194

• Improving a Mobile Brain-Computer Interface for Veterans with Paralysis

  This work is making a portable brain-computer interface better and easier to use for Veterans who have paralysis from conditions like spinal cord injury, stroke, or ALS.

  NIH research Providence VA Medical Center · Providence, United States · NIH-11193231

• Personalized symptom scores for people with one-sided vocal fold paralysis

  This project will create personalized ways to interpret patient questionnaires so people with one-sided vocal fold paralysis get care matched to their symptoms and preferences.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11169094

• Understanding Muscle Weakness and Stiffness Conditions

  This project explores the reasons behind muscle weakness and stiffness in conditions like periodic paralysis and myotonia, aiming to find new ways to help patients.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11126637

• A new therapy to restore voice in patients with vocal fold paralysis

  This study is testing a new treatment for vocal fold paralysis, which can cause voice loss, by using special cells from your own body to help improve muscle function in your vocal cords, and right now, they are trying it out in large animals to see how well it works.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11097326

• Developing a prosthetic device to help people with paralysis control movement.

  This study is exploring how certain parts of the brain can help people with paralysis control robotic arms or other assistive devices, making them work better and respond more naturally to what the user wants to do.

  NIH research California Institute of Technology · Pasadena, United States · NIH-11077790

• Investigating awareness and PTSD in patients on mechanical ventilation in the emergency department

  This study is looking at how many patients on ventilators in the emergency department are aware of what's happening around them and how that might affect their mental health, especially in terms of PTSD, so we can find better ways to help them feel more comfortable and supported during their care.

  NIH research Washington University · Saint Louis, United States · NIH-11060876

• Using muscle cells to treat vocal fold paralysis

  This study is looking at how special muscle cells can help improve voice and swallowing for people with vocal fold paralysis, often caused by nerve damage during thyroid surgery, and it will first test this treatment in dogs before moving on to humans.

  NIH research Washington University · Saint Louis, United States · NIH-11058973

• Exploring ways to prevent falls for people using exoskeletons with lower-limb paralysis

  This study is looking to make powered exoskeletons safer and better for veterans with lower-limb paralysis by finding ways to stop them from falling while they walk, so they can enjoy more independence in their daily lives.

  NIH research Louis Stokes Cleveland VA Medical Center · Cleveland, United States · NIH-11031349

• Annual symposium to advance treatments for spinal cord injury

  This symposium is bringing together researchers, advocates, and people who have experienced spinal cord injuries to work together on new treatments and make sure everyone has a voice in the process, especially those from underrepresented groups.

  NIH research Emory University · Atlanta, United States · NIH-11000598

• Developing a device to help restore walking in people with partial paralysis

  This study is looking to help Veterans with spinal cord injuries, strokes, or multiple sclerosis walk better and more safely in their everyday lives by testing a special device that stimulates their muscles, and it’s making sure the device is safe for those who need regular MRI scans.

  NIH research Louis Stokes Cleveland VA Medical Center · Cleveland, United States · NIH-10996763

• Improving patient care for vocal fold paralysis through personalized outcome measures

  This study is all about finding a better way to understand how people with vocal fold paralysis feel about their condition and treatment, so we can create personalized care plans that really fit each person's unique needs.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-10931717

• Understanding how sepsis affects the immune system and metabolism

  This study is looking at how sepsis affects the immune system, especially how it can weaken it, and it’s for critically ill patients to help find new ways to understand and treat this condition by examining their blood samples.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-10912771

• Understanding and treating muscle paralysis caused by genetic mutations

  This study is looking at Hyperkalemic Periodic Paralysis, a genetic condition that causes muscle weakness and paralysis, using mice to better understand how it works and to find better treatments for people living with this condition.

  NIH research Wright State University · Dayton, United States · NIH-10906368

• Enhancing arm movement control after paralysis

  This study is exploring a new way to help people with paralysis from spinal cord injuries move their arms again by using special technology that reads brain signals and stimulates muscles, so they can control their movements just by thinking about them.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-10879119

• Understanding muscle disorders that cause weakness and stiffness

  This study is looking into how certain genetic changes affect muscle function in people with periodic paralysis and myotonia, with the hope of finding new treatments to help improve their muscle strength and reduce stiffness.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-10863854

• Improving a mobile brain-computer interface for Veterans with paralysis

  This study is working on a new brain-computer interface that helps people with paralysis, especially Veterans, control devices like computers and prosthetics just by thinking about it, making it easier and more convenient for them to use at home.

  NIH research Providence VA Medical Center · Providence, United States · NIH-10854781

• Improving facial reanimation surgery outcomes for patients with facial paralysis

  This study is looking at ways to improve the results of facial reanimation surgery for people with facial paralysis by using 3D imaging to track recovery and comparing different surgical methods, all while considering how patients feel about their appearance and overall happiness after the surgery.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-10763039

• Controlling a robotic arm using head and facial movements for people with high-level paralysis

  This study is exploring how people with severe paralysis can use their head, tongue, and facial movements to control a robotic arm, helping them do everyday tasks like eating and personal care without needing surgery, all to improve their independence and quality of life.

  NIH research University of Arizona · Tucson, United States · NIH-10741948

• Understanding how muscles control voice production in people with vocal fold paralysis

  This study is looking at how the muscles in your voice box work to produce sound, especially for people who have trouble with their vocal cords, and it hopes to find better ways to help improve their voices.

  NIH research Rochester Institute of Technology · Rochester, United States · NIH-10696434

• Helping paraplegic individuals regain the ability to walk

  This study is exploring new ways to help people with complete paralysis walk and move again by using safe spinal cord stimulation and medications, along with training in a special suit, to improve their mobility and overall quality of life.

  NIH research University of Louisville · Louisville, United States · NIH-10686352

Related topics

Quick answers

How many Paralysis clinical trials are recruiting right now?

10, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 3 countries. The most sites are in United States (9 trials), Ireland (1 trial), United Kingdom (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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