CoPE II: Personalizing patient-reported outcomes for vocal fold paralysis care
Official title: CoPE II: Individualizing patient-reported outcomes in patient care for vocal fold paralysis in the clinic and in research
Funded at University of Wisconsin-Madison · NIH-11378997 · Data updated 2026-11-12
Aimed at tailoring patient-reported outcome measures to each person with unilateral vocal fold paralysis to better guide treatment decisions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | September 18, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $481,528 |
| NIH project number | 5R01DC021431-04 |
| Project ID | NIH-11378997 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults 21+ with unilateral vocal fold paralysis experiencing voice, swallowing, or psychosocial symptoms.
✕Less likely to help
Patients without vocal fold paralysis or those not experiencing PROM-defined concerns may not benefit.
What this research studies
This project focuses on making PROM scores more meaningful for individual patients with vocal fold paralysis by creating a personalized minimally clinically important difference (MCID). We will examine how factors like baseline severity and demographics affect PROM interpretation and how to apply this in clinical decisions. The work builds on existing methods and the Cord Paralysis Experience (CoPE) PROM to capture patient experiences and preferences. The goal is to improve responsiveness of PROMs to treatments in a diverse patient group. The study uses statistical methods to validate a personalized approach in a real clinical setting at UW–Madison.
Why it matters
Potential benefit: Patients could receive more personalized care choices that reflect what matters most to them and how they feel after treatment.
How similar studies have gone: Previous work has established CoPE and related PROM approaches; this project adds an individualized MCID layer to improve interpretation.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Francis, David O. — University of Wisconsin-Madison
- Study coordinator: Francis, David O.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.