Understanding and treating muscle paralysis caused by genetic mutations
Official title: Treating Hyperkalemic Periodic Paralysis
Funded at Wright State University · NIH-10906368 · Data updated 2026-11-12
This study is looking at Hyperkalemic Periodic Paralysis, a genetic condition that causes muscle weakness and paralysis, using mice to better understand how it works and to find better treatments for people living with this condition.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wright State University NIH-funded |
| Lab location | 1 site (Dayton, United States) |
| Project start | September 1, 2022 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $53,974 |
| NIH project number | 5F30AR081675-03 |
| Project ID | NIH-10906368 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Hyperkalemic Periodic Paralysis or those with a family history of the condition.
✕Less likely to help
Patients with other types of muscle disorders unrelated to HyperKPP may not benefit from this research.
What this research studies
This research focuses on Hyperkalemic Periodic Paralysis (HyperKPP), a genetic condition that leads to episodes of muscle weakness and paralysis. By using a mouse model that mimics the human condition, researchers aim to uncover the underlying mechanisms of muscle dysfunction and develop improved treatment strategies. The study involves advanced techniques to measure muscle responses and calcium signaling, which are critical for muscle contraction. The ultimate goal is to enhance current therapies and provide better management options for patients suffering from this condition.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with HyperKPP, reducing the frequency and severity of their muscle paralysis episodes.
How similar studies have gone: Previous research on ion channelopathies has shown promise in understanding and treating similar muscle disorders, indicating that this approach could yield valuable insights.
Where this research is happening
-
Wright State University
Dayton, United States Active
Researchers
- Principal investigator: Dupont, Christopher — Wright State University
- Study coordinator: Dupont, Christopher
Related research
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A clinician-scientist is pursuing five years of advanced training and research to better understand and care for people with neuromuscular diseases related to hyperkalemic paralysis.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.