Personalized symptom scores for people with one-sided vocal fold paralysis
CoPE II: Individualizing patient-reported outcomes in patient care for vocal fold paralysis in the clinic and in research
['FUNDING_R01'] · UNIVERSITY OF WISCONSIN-MADISON · NIH-11169094
This project will create personalized ways to interpret patient questionnaires so people with one-sided vocal fold paralysis get care matched to their symptoms and preferences.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WISCONSIN-MADISON (nih funded) |
| Locations | 1 site (MADISON, UNITED STATES) |
| Trial ID | NIH-11169094 on ClinicalTrials.gov |
What this research studies
You would complete the CoPE questionnaire about your voice, swallowing, breathing, and quality of life, and researchers will use your answers plus your medical background to tailor what counts as a meaningful change for you. The team will combine baseline severity, sociodemographic details, and symptom patterns with statistical models to produce an individualized minimal clinically important difference (MCID) for each person. They will test these personalized thresholds in clinic and research settings to see if they help doctors and patients make better treatment decisions. This work builds on a validated CoPE questionnaire and aims to make PROM scores more useful for individual care.
Who could benefit from this research
Good fit: Adults (age 21 and older) with unilateral vocal fold paralysis who have voice, swallowing, breathing, or related quality-of-life concerns and receive care at participating clinics.
Not a fit: People without vocal fold paralysis, children under 21, or those not seen at participating sites would not be expected to benefit directly from this project.
Why it matters
Potential benefit: If successful, this could help your care team know whether a treatment made a meaningful difference for your voice, swallowing, or breathing based on your own situation.
How similar studies have performed: The team has previously developed and validated the CoPE patient questionnaire, but creating and using individualized MCID thresholds is a novel approach not yet widely implemented in routine care.
Where this research is happening
MADISON, UNITED STATES
- UNIVERSITY OF WISCONSIN-MADISON — MADISON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FRANCIS, DAVID O. — UNIVERSITY OF WISCONSIN-MADISON
- Study coordinator: FRANCIS, DAVID O.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.