Understanding how sepsis affects the immune system and metabolism
Official title: Cellular and Metabolic Dysfunction in Sepsis-Induced Immune Paralysis
Funded at Weill Medical Coll of Cornell Univ · NIH-10912771 · Data updated 2026-11-12
This study is looking at how sepsis affects the immune system, especially how it can weaken it, and it’s for critically ill patients to help find new ways to understand and treat this condition by examining their blood samples.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $196,020 |
| NIH project number | 5K23GM151730-02 |
| Project ID | NIH-10912771 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include critically ill patients diagnosed with sepsis, particularly those exhibiting signs of immune paralysis.
✕Less likely to help
Patients who are not critically ill or do not have a diagnosis of sepsis may not benefit from this research.
What this research studies
This research investigates the effects of sepsis on the immune system, particularly focusing on a condition known as sepsis-induced immune paralysis. It aims to explore how changes in fatty acid metabolism and immune cell signaling contribute to this condition. By analyzing blood samples from critically ill patients, the study will identify specific metabolic and protein biomarkers that could help in understanding and potentially treating sepsis-related immune dysfunction.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and treatments for patients suffering from sepsis and its long-term effects.
How similar studies have gone: Previous research has shown promising results in understanding immune dysfunction in sepsis, but this specific approach focusing on metabolic biomarkers is relatively novel.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Torres, Lisa Kristina — Weill Medical Coll of Cornell Univ
- Study coordinator: Torres, Lisa Kristina
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.