Helping paraplegic individuals regain the ability to walk
Transformation of Paraplegic Paralysis to Overground Stepping in Humans
['FUNDING_R01'] · UNIVERSITY OF LOUISVILLE · NIH-10686352
This study is exploring new ways to help people with complete paralysis walk and move again by using safe spinal cord stimulation and medications, along with training in a special suit, to improve their mobility and overall quality of life.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF LOUISVILLE (nih funded) |
| Locations | 1 site (LOUISVILLE, UNITED STATES) |
| Trial ID | NIH-10686352 on ClinicalTrials.gov |
What this research studies
This research investigates innovative methods to enable individuals with complete paralysis to regain the ability to walk and perform voluntary movements. By using noninvasive spinal cord stimulation combined with pharmacological treatments, the study aims to enhance motor control in paralyzed subjects. The approach includes training with an exoskeleton to improve mobility and quality of life for participants. The research builds on previous successes in animal models and aims to translate these findings to human applications.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with complete paralysis due to spinal cord injuries who are seeking to regain locomotor function.
Not a fit: Patients with incomplete paralysis or those whose paralysis is due to conditions other than spinal cord injuries may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve mobility and independence for individuals with paraplegia.
How similar studies have performed: Previous studies have shown promising results in animal models, indicating potential for success in human applications.
Where this research is happening
LOUISVILLE, UNITED STATES
- UNIVERSITY OF LOUISVILLE — LOUISVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: OVECHKIN, ALEXANDER VLADIMIROVICH — UNIVERSITY OF LOUISVILLE
- Study coordinator: OVECHKIN, ALEXANDER VLADIMIROVICH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.