Developing a new treatment for severe mouth sores in cancer patients
Official title: IND-enabling toxicology studies to reach IND approval for a proprietary biologic to treat oral mucositis in cancer patients
Funded at Allander Biotechnologies, INC. · NIH-10933015 · Data updated 2026-11-12
This study is testing a new gel treatment for mouth sores that can happen during cancer radiation therapy, aiming to help patients heal better and feel more comfortable while they receive their treatment.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Allander Biotechnologies, INC. NIH-funded |
| Lab location | 1 site (Aurora, United States) |
| Project start | September 21, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $1,230,285 |
| NIH project number | 5SB1DE024659-05 |
| Project ID | NIH-10933015 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are cancer patients undergoing radiation therapy who are at risk of developing oral mucositis.
✕Less likely to help
Patients who are not undergoing radiation therapy or who do not develop oral mucositis may not benefit from this research.
What this research studies
This research focuses on creating a new biologic treatment for oral mucositis, a painful condition that often affects cancer patients undergoing radiation therapy. The approach involves applying a specially formulated gel to the oral mucosa, which has shown promising results in preclinical trials with animals. The goal is to improve healing and reduce the severity of mouth sores, allowing patients to tolerate cancer treatments better. The research will also ensure that the treatment meets regulatory standards for safety and efficacy.
Why it matters
Potential benefit: If successful, this research could provide a new effective treatment option for cancer patients suffering from oral mucositis, improving their quality of life and treatment outcomes.
How similar studies have gone: Previous research has shown success with similar biologic treatments in animal models, indicating potential for effective application in humans.
Where this research is happening
-
Allander Biotechnologies, INC.
Aurora, United States Active
Researchers
- Principal investigator: Young, Christian — Allander Biotechnologies, INC.
- Study coordinator: Young, Christian
Related research
Other NIH-funded projects on the same topics.
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Understanding how biological sex affects radiation-induced oral mucositis
This grant explores why women and men experience different severity of mouth sores during head and neck cancer radiotherapy and how to tailor treatments to reduce pain and healing time.
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First-in-human topical gel for preventing and treating radiation-induced oral ulcers in cancer patients
A new oral gel applied to the mouth is being tested to prevent and treat painful mouth ulcers caused by cancer radiation therapy, with early safety and dosing data gathered in people.
-
New medicine to prevent or lessen painful mouth sores from radiation
This project develops a potential drug to prevent or shorten painful mouth sores that happen after radiation therapy for head and neck cancer.
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Protecting the mouth from radiation in head and neck cancer
A Duke University-based study looks at how the p53 protein may guard the mouth from radiation-related damage in people with head and neck cancer.
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Prophylactic and therapeutic oral gel to prevent and treat radiation-induced mouth ulcers in cancer patients
A new topical gel shown in animals may prevent or treat painful mouth ulcers caused by cancer radiation therapy, with plans to move toward human testing.
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A new medicine to prevent and treat radiation-related mouth sores
A new oral drug is being developed to prevent or shorten painful mouth sores in people getting radiation to the head and neck.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.