Condition

Hematological Malignancies clinical trials and research

• 20Clinical trials
• 16NIH research projects
• 15Countries

Newest Hematological Malignancies clinical trials

All recruiting trials (20)

• Lower Dose Cyclophosphamide After Haploidentical Stem Cell Transplant

  This trial tests whether giving half the usual amount of cyclophosphamide after haploidentical stem cell transplantation can still prevent GVHD in adults with blood cancers.

  Recruiting Phase 2 Tata Memorial Centre · Navi Mumbai, Maharashtra and 1 other locations · NCT07719946

• Chlorophyllin to reduce mouth sores before allogeneic stem cell transplant

  This phase II study tests whether taking chlorophyllin by mouth can lower the chances and severity of mouth ulcers in patients aged 12–65 undergoing radiation-based conditioning before a first allogeneic stem cell transplant.

  Recruiting Phase 2 Tata Memorial Centre · Navi Mumbai, Maharashtra · NCT07709195

• First-in-human test of DS3790a for hematological malignancies

  This first-in-human trial will test DS3790a alone and with other drugs to see if it's safe, how it behaves in the body, and whether it helps adults with hematological malignancies.

  Recruiting at 8 sites Phase 1/2 Daiichi Sankyo · New York, New York and 7 other locations · NCT07220616

• 18F‑Pentixafor PET imaging for blood cancers

  This will test whether 18F‑Pentixafor PET scans help diagnose, stage, and check treatment response in adults with suspected or confirmed hematologic malignancies.

  Recruiting First Affiliated Hospital of Zhejiang University · Hangzhou, Zhejiang · NCT07122674

• Improving GVHD prevention after donor stem cell transplant

  This study will test whether a lower dose versus the standard dose of post-transplant cyclophosphamide, given with sirolimus and MMF, improves quality of life for people aged 60 and older having a reduced-intensity allogeneic stem cell transplant.

  Recruiting Phase 2 University of Nebraska · Omaha, Nebraska · NCT06799195

• Long-term follow-up for patients treated with Galapagos CAR T-cell therapies

  This study is checking how well Galapagos CAR T-cell therapies work and their safety for patients over 15 years after treatment.

  Recruiting at 11 sites Phase 3 Lakefront Biotherapeutics NV · Boston, Massachusetts and 10 other locations · NCT06652633

• Longitudinal study of CAR-T cell therapy in patients with blood cancers

  This study looks at how well CAR-T cell therapy works for Chinese patients with blood cancers by gathering information from those who have already received this treatment.

  Recruiting Institute of Hematology & Blood Diseases Hospital, China · Tianjin, Tianjin Municipality · NCT06607289

• Registry for drug response profiling in pediatric blood cancers

  This study is testing how well different cancer drugs work on blood cancer cells from kids to help find the best treatment for those who haven't responded to other therapies.

  Recruiting University Children's Hospital, Zurich · Zurich, Canton of Zurich · NCT06550102

• Oral treatment with HMPL-506 for patients with blood cancers

  This study is testing an oral medication called HMPL-506 to see if it can safely help patients with blood cancers like relapsed or refractory Acute Myeloid Leukemia and Acute Lymphocytic Leukemia.

  Recruiting at 13 sites Phase 1 Hutchmed · Changsha and 15 other locations · NCT06387082

• Hematopoietic stem cell transplant using haploidentical donor grafts depleted of TCRα/β and CD45RA

  This pilot, single-arm study tests a specially prepared haploidentical stem cell graft in adults needing a transplant due to blood cancers when a matched donor isn’t available.

  Recruiting Miltenyi Biomedicine GmbH · Duarte, California · NCT06225050

• Evaluating DXC006 for patients with advanced solid tumors and blood cancers

  This study is testing a new treatment called DXC006 to see if it's safe and effective for adults with advanced solid tumors and blood cancers who haven't had success with other therapies.

  Recruiting at 5 sites Phase 1 Hangzhou DAC Biotechnology Co., Ltd. · Hefei, Anhui and 4 other locations · NCT06224855

• Using inhaled ginger and lemon aromatherapy to reduce nausea and vomiting in cancer patients

  This study is testing if breathing in a mix of ginger and lemon scents can help cancer patients feel less nauseous and vomit less during chemotherapy.

  Recruiting at 4 sites University Hospital, Limoges · Brivé and 3 other locations · NCT06150469

• Evaluating ICP-248 for treating mature B-cell cancers

  This study is testing a new treatment called ICP-248, alone and with another drug, to see if it can help people with mature B-cell cancers.

  Recruiting at 22 sites Phase 1 Beijing InnoCare Pharma Tech Co., Ltd. · Bengbu, Anhui and 21 other locations · NCT05728658

• Using physical activity and relaxation techniques to reduce anxiety in ICU patients with blood cancers

  This study is testing if physical activity and relaxation techniques can help reduce anxiety in ICU patients with blood cancers.

  Recruiting Centre Hospitalier Régional Metz-Thionville · Metz · NCT05475600

• Nurse-led conversations to integrate palliative care for children with cancer

  This study is testing if having nurses lead conversations about palliative care can help children with cancer and their families get better support right after a diagnosis or relapse.

  Recruiting Children's Hospital of Fudan University · Shanghai, Minhang · NCT05306509

• Evaluating SMART101 for immune recovery in patients with blood cancers after stem cell transplant

  This study is testing if a new treatment called SMART101 can help improve immune recovery in kids and adults who have had a stem cell transplant for blood cancers.

  Recruiting Phase 1/2 Smart Immune SAS · New York, New York · NCT04959903

• Evaluating talquetamab for patients with relapsed or refractory multiple myeloma

  This study is testing a new drug called talquetamab to see if it can help people with relapsed or refractory multiple myeloma feel better and manage their disease.

  Recruiting at 14 sites Phase 2 Janssen Research & Development, LLC · Birmingham, Alabama and 77 other locations · NCT04634552

• Cord blood transplantation with a specific conditioning regimen and post-transplant treatment

  This study is testing a new way to use cord blood for transplants to see if a specific treatment can help prevent complications and improve recovery for patients receiving the transplant.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Roma, RM · NCT03802773

• Assessing molecular changes in blood cancers

  This study is trying to see how changes in blood samples from people with early blood cancers can help us understand their condition better and find new treatment options.

  Recruiting at 7 sites Dana-Farber Cancer Institute · Boston, Massachusetts and 6 other locations · NCT02269592

• Observational study of neutropenic patients in Cologne

  This study looks at patients who have low white blood cell counts after chemotherapy for blood cancers to see how it affects their health and what treatments work best for them.

  Recruiting University Hospital of Cologne · Cologne, North Rhine-Westphalia · NCT01821456

NIH-funded research (16)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Engineering CD19 mimotopes to boost and broaden CD19-CAR T cell therapy

  A patient-focused look at improving existing CD19-CAR T cell therapy so more people with blood cancers might benefit.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-11449957

• Disrupting BM niches and boostingCAR-T therapy in blood cancers

  A program at Washington University is developing better ways to collect stem cells for transplantation, reduce graft-versus-host disease, and improve CAR-T cell therapies for blood cancers.

  NIH research Washington University · Saint Louis, United States · NIH-11446216

• Time-restricted eating to help fatigue in blood cancer survivors

  A 12-week program tests whether eating within a daytime 10-hour window can reduce fatigue in people who have survived blood cancers.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-11382896

• Optimizing Blood Stem Cell Transplants for Blood C cancers and related diseases

  This grant supports improving how stem cell transplants are collected and given, with the goal of better outcomes and fewer side effects for people with blood cancers and some autoimmune or inherited conditions.

  NIH research Washington University · Saint Louis, United States · NIH-11370616

• Tailoring a fun, tech-assisted mental health program for teens and young adults with blood cancers

  A planning grant to adapt a technology-based cognitive behavioral therapy program to meet the unique needs of adolescents and young adults with hematologic cancers.

  NIH research University of Chicago · Chicago, United States · NIH-11362023

• Off-the-Shelf Immune Cells to Fight Childhood Blood Cancers

  A US study from Minnesota is exploring ready-to-use immune cells to treat kids with leukemia that may not respond to standard therapies.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11324629

• Improving care for leukemia and other blood cancers

  This program is developing better ways to diagnose, predict outcomes, and treat leukemia and related blood cancers for children and adults.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11263185

• Heat shock factors and how they help leukemia cells survive

  Researchers are exploring whether blocking a protein called HSF1 can make adults with acute myeloid leukemia (AML) respond better to treatment.

  NIH research Augusta University · Augusta, United States · NIH-11251979

• Improving Stem Cell Transplants for Blood Cancers and Other Diseases

  This work aims to make stem cell transplants safer and more effective for people with blood cancers, autoimmune diseases, and other serious conditions.

  NIH research Washington University · Saint Louis, United States · NIH-11228615

• Daily time-restricted eating to ease fatigue after blood cancers

  This project sees whether limiting eating to a 10-hour daytime window can help people who finished treatment for blood cancers feel less tired.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-11187059

• Changing the bone marrow environment to help immunotherapy for blood cancers

  Developing new ways to alter the bone marrow so immunotherapies and donor stem-cell transplants work better for people with blood cancers and related disorders.

  NIH research Washington University · Saint Louis, United States · NIH-11171350

• Investigating genetic mutations in aggressive blood cancers.

  This study is looking at how certain gene changes might lead to peripheral T cell lymphoma, an aggressive blood cancer, using special mice that have similar genetic traits to help find new ways to treat the disease, which could ultimately help patients understand and manage their condition better.

  NIH research Texas A&m University Health Science Ctr · College Station, United States · NIH-11063983

• Investigating the role of heat shock factors in blood cancers

  This study is looking at how certain proteins called heat shock transcription factors affect the growth of acute myeloid leukemia (AML) and other blood cancers, with the goal of finding better treatments that could help patients feel better and live longer.

  NIH research Augusta University · Augusta, United States · NIH-11001951

• Using time-restricted eating to help cancer survivors with fatigue

  This study is looking at whether eating all your meals within a 10-hour window each day can help reduce tiredness in people who have survived blood cancers, and it’s designed for those who want to feel more energetic after their treatment.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-10978430

• Investigating how BAK protein activation affects blood cancers

  This study is looking at how a protein called BAK helps trigger the death of cancer cells, especially in patients with acute myeloid leukemia (AML), by examining blood samples and leukemia cells to find new ways to make cancer treatments more effective.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-10886663

• Training program for childhood blood cancers

  This program is all about helping new scientists learn how to create better treatments for kids with blood cancers by using the latest genetic discoveries, so they can improve how these cancers are diagnosed and treated.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-10849301

Related topics

Quick answers

How many Hematological Malignancies clinical trials are recruiting right now?

20, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 15 countries. The most sites are in China (7 trials), United States (7 trials), France (4 trials), Belgium (2 trials), Germany (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 4, Phase 1: 3, Phase 1/2: 2, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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