Condition

Head and Neck Neoplasms clinical trials and research

• 29Clinical trials
• 18Countries

Newest Head and Neck Neoplasms clinical trials

All recruiting trials (29)

• Longer antibiotic prophylaxis after head and neck cancer surgery

  This trial tests whether giving antibiotics for 7 days after major mouth and throat cancer surgery reduces wound infections compared with the standard 24-hour course.

  Recruiting Phase 3 AC Camargo Cancer Center · São Paulo, São Paulo · NCT07851857

• Tai Chi during radiotherapy for head and neck cancer fatigue

  This trial tests whether a 12-week Yang-style Tai Chi program added to usual care can reduce cancer-related fatigue in adults with head and neck cancer undergoing radiotherapy.

  Recruiting West China Hospital · Chengdu, Sichuan · NCT07809776

• Topical Boswellia 2% Cream to Prevent Radiation Dermatitis in Head and Neck Cancer

  A topical 2% Boswellia serrata cream is tested to see if it can prevent skin irritation from radiation in people with head and neck cancer.

  Recruiting at 2 sites Alexandria University · Alexandria and 1 other locations · NCT07778290

• Methylscape test in body fluids for multi-cancer detection in Colombia

  A simple blood, urine, or saliva test called Methylscape is being tested to see if it can detect multiple cancers and identify where the signal is coming from, using people with cancer and healthy volunteers in Colombia.

  Recruiting Centro de Tratamiento e Investigación sobre Cáncer, Luis Carlos Sarmiento Angulo · Bogotá, Bogota D.C. · NCT07741435

• Foot reflexology and ta-VNS for symptom relief in head and neck cancer during CCRT

  This trial tests whether foot reflexology, transcutaneous auricular vagus nerve stimulation, and auricular acupressure can reduce pain, dry mouth, fatigue, and other symptoms for head and neck cancer patients receiving cisplatin-based chemoradiotherapy.

  Recruiting Tzu Chi University · Hualien City · NCT07711626

• Ozone gas plus biomimetic toothpaste and mouthwash to treat cancer therapy mouth sores

  This trial will test whether adding a biomimetic toothpaste and mouthwash to ozone gas therapy helps adults with chemo- or radiotherapy-induced mouth sores heal faster and have less pain.

  Recruiting University of Pavia · Pavia, Lombardy · NCT07491536

• Intratumoral injection of N17350 in advanced solid tumors

  Aims to see if injected N17350 can shrink or control tumors in adults with advanced solid cancers who have few other options.

  Recruiting at 7 sites Phase 1/2 Onchilles Pharma Inc · Los Angeles, California and 8 other locations · NCT07339176

• DPYD-guided fluoropyrimidine dose adjustment for patients with one DPYD gene variant

  This trial will test whether giving lower doses of fluoropyrimidine chemotherapy based on a patient's DPYD gene result reduces severe (Grade 3–4) side effects in people with colorectal, breast, or head and neck cancers who carry one DPYD variant.

  Recruiting at 12 sites Phase 4 Rutgers, The State University of New Jersey · Belleville, New Jersey and 11 other locations · NCT07158164

• Tailored reduced-intensity treatment for older adults with head and neck cancer

  This trial tests whether a lower-intensity, PD-L1-guided chemoimmunotherapy approach followed by radiation helps frail patients aged 65 and older with stage IB–IVA squamous cell head and neck cancer.

  Recruiting Phase 3 Brown University · Providence, Rhode Island · NCT06998069

• Zanzalintinib with pembrolizumab and cetuximab for recurrent or metastatic head and neck squamous cell cancer

  This trial tests whether adding the oral drug zanzalintinib to pembrolizumab and cetuximab is safe and finds the best dose for adults with recurrent or metastatic head and neck squamous cell cancer.

  Recruiting Phase 1 University of Chicago · Chicago, Illinois · NCT06912087

• Comparing upfront surgery and chemotherapy followed by surgery for oral cancer

  This study is testing if starting with chemotherapy before surgery can help people with advanced oral cancer do better than having surgery right away.

  Recruiting Phase 3 All India Institute of Medical Sciences, Jodhpur · Bhubaneswar, Odisha and 6 other locations · NCT06737822

• Collection of biological samples for research on head and neck disorders

  This study is collecting biological samples from people with head and neck disorders to see how these conditions develop and find better ways to diagnose and treat them.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT06303180

• Testing a decision-support tool for patients with head and neck cancer

  This study is testing a new support tool to help patients with head and neck cancer make better choices about joining clinical trials.

  Recruiting University of Aarhus · Aarhus · NCT06291610

• Evaluating HTL0039732 for Advanced Solid Tumours

  This study is testing a new drug called HTL0039732, alone and with another treatment, to see if it can help people with advanced solid tumors by boosting their immune response against cancer.

  Recruiting at 6 sites Phase 1/2 Cancer Research UK · Cambridge and 5 other locations · NCT05944237

• A program to support head and neck cancer survivors and their caregivers

  This study is testing a new support program for head and neck cancer survivors and their caregivers to see if it helps them manage symptoms and reduces stress compared to regular care.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT05811936

• Reducing radiation and chemotherapy for head and neck cancer treatment

  This study is testing if giving less radiation and chemotherapy before surgery can still effectively treat certain head and neck cancers while reducing side effects for patients.

  Recruiting at 6 sites Phase 2 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 5 other locations · NCT05544136

• Combination therapy with atezolizumab and tiragolumab for solid tumors

  This study is testing a new combination treatment using two immune-boosting drugs for people with solid tumors, like melanoma and head and neck cancers, to see if it can help them fight their cancer better than current treatments.

  Recruiting Phase 2 University Medical Center Groningen · Groningen · NCT05483400

• Preventive physical activity for head and neck cancer patients

  This study tests if a special exercise program can help head and neck cancer patients feel better and function well during their radiation treatment.

  Recruiting Sahlgrenska University Hospital · Gothenburg · NCT05432297

• Using Pembrolizumab with Chemotherapy for Head and Neck Cancer

  This study is testing if combining a blood test that checks tumor DNA with chemotherapy and immunotherapy can help people with head and neck cancer get better results than using immunotherapy alone.

  Recruiting Phase 2 University of Chicago · Chicago, Illinois · NCT05420948

• Combination treatment of Penpulimab and Cetuximab for advanced head and neck cancer

  This study is testing a new combination of two medications, Penpulimab and Cetuximab, to see if they can help people with advanced head and neck cancer who haven't had treatment before.

  Recruiting at 2 sites Phase 2 Eye & ENT Hospital of Fudan University · Changchun, Jilin and 1 other locations · NCT05260671

• Sparing swallowing and aspiration risk organs in head and neck cancer treatment

  This study is testing a new type of radiation therapy that aims to protect swallowing and aspiration-related organs in people with head and neck cancer to see if it helps them swallow better and have fewer side effects.

  Recruiting Phase 3 All India Institute of Medical Sciences · Jhajjar, Haryana · NCT05187091

• Using light therapy and mobile health to improve quality of life in head and neck cancer patients

  This study is testing whether light therapy can help improve the quality of life and oral health for people who have survived head and neck cancer and are dealing with dry mouth from radiation treatment.

  Recruiting Universidad de Granada · Granada · NCT05106608

• Imaging for personalized treatment of head and neck cancer

  This study is testing if using advanced imaging techniques can help personalize radiotherapy for people with head and neck cancer to improve their treatment results and reduce side effects.

  Recruiting Norwegian University of Science and Technology · Tromsø and 1 other locations · NCT04612075

• Investigating BCA101 for advanced solid tumors driven by EGFR

  This study is testing a new treatment called BCA101 to see if it can help people with advanced solid tumors that are driven by EGFR, especially those who haven't responded to other therapies.

  Recruiting at 21 sites Phase 1 Bicara Therapeutics · La Jolla, California and 20 other locations · NCT04429542

• Evaluating the impact of MR-guided radiation therapy on cancer treatment outcomes

  This study is testing how using a special type of radiation therapy with real-time imaging can improve treatment results and quality of life for adults with cancer.

  Recruiting at 14 sites UMC Utrecht · Pittsburgh, Pennsylvania and 17 other locations · NCT04075305

• Impact of breathing exercises on swallowing in head and neck cancer patients

  This study is testing if breathing exercises can help improve swallowing for people with newly diagnosed head and neck cancer who are getting radiation or chemotherapy.

  Recruiting University of Wisconsin, Milwaukee · Milwaukee, Wisconsin and 1 other locations · NCT03916809

• Effects of Radiotherapy and Chemotherapy on Hearing in Head and Neck Cancer Patients

  This study is trying to see how treatments for head and neck cancer, like radiotherapy and chemotherapy, affect hearing in patients and which parts of the ear are most at risk of damage.

  Recruiting University of Manchester · Manchester · NCT03914378

• Collecting tissue samples for head and neck disorders

  This study is collecting leftover tissue samples from people with head and neck disorders to help researchers learn more about these conditions and find better treatments.

  Recruiting at 9 sites National Institutes of Health Clinical Center (CC) · Washington D.C., District of Columbia and 8 other locations · NCT03429036

• Analyzing the genetic profiles of head and neck tumors

  This study is trying to see if looking at the genes in head and neck tumors can help predict how well patients will respond to treatment and their overall outcomes.

  Recruiting Montefiore Medical Center · The Bronx, New York · NCT00200486

Related topics

Quick answers

How many Head and Neck Neoplasms clinical trials are recruiting right now?

29, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 18 countries. The most sites are in United States (13 trials), Australia (3 trials), United Kingdom (3 trials), China (2 trials), India (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 4, Phase 3: 4, Phase 1: 2, Phase 1/2: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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