Chlorophyllin to reduce mouth sores before allogeneic stem cell transplant

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a single-arm Phase II trial evaluating oral sodium copper chlorophyllin as a preventive measure against radiation-induced oral mucositis in patients receiving myeloablative total body irradiation prior to their first allogeneic HSCT. Participants will start 750 mg daily 48 hours before conditioning and continue through day +28 after transplant. The study focuses on whether chlorophyllin can reduce the incidence of Grade III/IV mucositis, shorten its duration, and lessen related supportive-care needs while maintaining safety. Outcomes include rates of severe mucositis, duration, nutrition support requirements, analgesic use, and treatment-related toxicities. The trial addresses the lack of widely available prophylaxis for radiation-induced mucositis in this setting.

Why it matters

Who can join: the full rules

Inclusion Criteria

* Patients ≥12 and ≤65 years of age
* First allogeneic stem cell transplant
* Total body irradiation dose (fractionated) ≥8 Gy

Exclusion Criteria

* Known hypersensitivity or contraindications to sodium chlorophyllin (CHL)

Where it's running

• Advanced Centre for Treatment, Research and Education in Cancer
  Navi Mumbai, Maharashtra, India Recruiting

Study contacts

• Study coordinator: Sumeet Mirgh, MBBS MD DM Clinical Hematology
• Email: drsumeetmirgh@gmail.com
• Phone: +91 9769918905

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.