Using light therapy to prevent mouth sores in patients getting stem cell transplants

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot study evaluates the effectiveness of intraoral photobiomodulation therapy (PBMT) in preventing oral mucositis in patients undergoing myeloablative allogeneic hematopoietic cell transplantation (alloHCT). Participants will receive daily PBMT using a novel LED device, the THOR LX2.3 with LED Lollipop, starting from the conditioning chemotherapy phase until day +20 or discharge. The study aims to assess the impact of this light-based therapy on reducing inflammation and enhancing wound healing in the oral cavity. Approximately 20 patients will be enrolled in this single-center study at Brigham and Women's Hospital.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Planned to undergo myeloablative allogeneic HCT using FluBu4 conditioning and Tac-Mtx GVHD prophylaxis.
* Age ≥18 years.
* Ability to understand and the willingness to sign a written informed consent document.

Exclusion Criteria:

* Participants who have had treatment with intraoral PBMT within four weeks of admission for HSCT.
* Participants who have a history of radiation therapy to the head and neck.
* Participants who have a history of photosensitivity or underlying disease with known photosensitivity.
* Participants who are planned to receive palifermin for OM prevention.

Where it's running

• Brigham and Women's Hospital
  Boston, Massachusetts, United States Recruiting

Study contacts

• Principal investigator: Kentaro Ikeda, DDS, MPH — Brigham and Women's Hospital
• Study coordinator: Kentaro Ikeda, DDS,MPH
• Email: kikeda4@bwh.harvard.edu
• Phone: 617-732-6570

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Amimestrocel infusion to prevent severe mouth sores after allogeneic stem cell transplant

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.