Condition

Head & Neck Cancer clinical trials and research

• 23Clinical trials
• 8NIH research projects
• 1New in 30 days
• 13Countries

Newest Head & Neck Cancer clinical trials

All recruiting trials (23)

• Proton Re-irradiation for Recurrent or Second Primary Head and Neck Cancer

  This study tests proton radiotherapy to see if it can control head and neck cancer that has come back or appeared again in the same area, while trying to limit side effects.

  Recruiting Oslo University Hospital · Bergen and 3 other locations · NCT07922967

• TS-104: a first-in-human, dose-escalation study for advanced solid tumors

  This study tests TS-104, a peptide-drug conjugate, as a single therapy in adults with advanced solid tumors like NSCLC, HNSCC, esophageal, gastric, ovarian, or endometrial cancer to see if it is safe and tolerable and whether it shows any benefit.

  Recruiting at 3 sites Phase 1 TwoStep Therapeutics, Inc. · Maumee, Ohio and 2 other locations · NCT07814248

• BupiZenge vs Lidocaine for mouth pain from oral mucositis in head and neck cancer

  A phase 3 trial tests whether the BupiZenge lozenge provides better pain relief than lidocaine for mouth sores caused by radiation in head and neck cancer patients.

  Recruiting at 9 sites Phase 3 OncoZenge AB · Copenhagen and 10 other locations · NCT07672236

• Proton Re-irradiation for Head and Neck Cancer Recurrence

  This study tests whether proton therapy as a second round of radiation is safe and helpful for adults with head and neck cancer that has come back after prior treatment.

  Recruiting Istituto Clinico Humanitas · Rozzano, Milano · NCT07635641

• Intratumoral EDS01 plus toripalimab for recurrent or metastatic head and neck cancer

  This phase 1 study tests whether directly injecting a gene‑therapy endostatin product (EDS01) into a tumor, together with the PD-1 inhibitor toripalimab, is safe and shows early signs of activity in adults with recurrent or metastatic head and neck cancer after platinum therapy.

  Recruiting Phase 1 West China Hospital · Chengdu, China · NCT07625423

• Specialist nurse-led perioperative nursing care for head and neck cancer surgery

  A multidisciplinary team of specialist nurses tests whether a nurse-led perioperative care plan improves recovery for people having head and neck cancer surgery.

  Recruiting Tianjin Medical University Cancer Institute and Hospital · Tianjin · NCT07622381

• Nimotuzumab plus Immunotherapy and Chemotherapy before surgery for locally advanced head and neck cancer

  This phase 2 trial tests whether adding nimotuzumab to immunotherapy and chemotherapy before surgery helps people with locally advanced head and neck squamous cell carcinoma.

  Recruiting Phase 2 Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine · Shanghai · NCT07601737

• Home-based supervised exercise program beforeHead and neck cancer surgery

  This study tests a supervised, at-home exercise plan to help people with head and neck cancer regain strength and function after surgery.

  Recruiting Centre Henri Becquerel · Rouen · NCT07560397

• FL-261 imaging to detect and stage c-MET–expressing cancers

  This first-in-human test uses FL-261 labeled for PET or SPECT to see if it safely highlights c-MET–positive tumors in adults with advanced solid tumors such as non-small cell lung, colorectal, or head and neck cancer.

  Recruiting Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan, Hubei · NCT07510321

• Immune changes that may stop laryngeal dysplasia from becoming cancer

  This project will see if immune cells and gene activity in adults with laryngeal dysplasia can predict which lesions will turn into cancer.

  Recruiting European Institute of Oncology · Milan, MI · NCT07508319

• Safety and dosing of 177Lu-INN805 in patients with malignant solid tumors

  This early-phase, single-arm study tests different dose levels of 177Lu-INN805 to see if it can be safely given and if it shows signs of activity in adults with hard-to-treat solid tumors.

  Recruiting Early Phase 1 FindCure Biosciences (ZhongShan) Co., Ltd. · Wuxi, Jiangsu · NCT07459283

• Early PET/CT response after first‑line pembrolizumab in recurrent or metastatic head and neck cancer

  This project will see if an 18F‑FDG PET/CT scan after two doses of pembrolizumab can tell who is responding among patients with recurrent or metastatic PD‑L1 CPS ≥1 head and neck cancer.

  Recruiting University of Rome Tor Vergata · Rome, Italy · NCT07448727

• Postoperative radiotherapy with nimotuzumab followed by bemcentinib for high-risk head and neck cancer patients who can't take cisplatin

  This study will see if adding nimotuzumab during postoperative radiotherapy followed by bemcentinib can help prevent recurrence in high-risk head and neck cancer patients who are unable to receive cisplatin.

  Recruiting Phase 3 Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University · Shanghai · NCT07445048

• MRI-guided focused ultrasound mesencephalotomy for opioid-resistant head, neck, and brachial cancer pain

  This study will try MRI-guided focused ultrasound to make a tiny, precise lesion in the midbrain to relieve severe, opioid-resistant head, neck, or brachial cancer pain.

  Recruiting University of Virginia · Boston, Massachusetts and 5 other locations · NCT07405645

• Nimotuzumab plus toripalimab and chemotherapy for locally advanced tonsillar cancer

  This trial will try giving nimotuzumab and toripalimab together with chemotherapy before surgery to see if it increases complete tumor response in people with resectable, locally advanced tonsillar cancer.

  Recruiting Phase 2 Tang-Du Hospital · Shanxi, Province · NCT07353723

• SL-28 for Advanced Solid Tumours

  A new allogeneic cell therapy called SL-28 is being tested in adults with advanced solid tumors to see if it is safe and can help shrink tumors.

  Recruiting Phase 1/2 Second Life Therapeutics · Sydney, New South Wales and 2 other locations · NCT07341737

• Radiotherapy with nimotuzumab versus radiotherapy alone for platinum-ineligible advanced head and neck squamous cell carcinoma

  This trial tests whether adding nimotuzumab to radiotherapy helps people with advanced head and neck squamous cell carcinoma who cannot receive platinum chemotherapy.

  Recruiting Phase 3 Shandong Cancer Hospital and Institute · Shandong, Province · NCT07333274

• Contrast-enhanced ultrasound to locate sentinel lymph nodes during cancer surgery

  This will test whether a contrast-enhanced ultrasound scan using Sonazoid can find sentinel lymph nodes during surgery in adults with melanoma, breast cancer, or head and neck cancer.

  Recruiting Phase 2/3 The Netherlands Cancer Institute · Amsterdam, North Holland · NCT07310758

• OM-RCA-01 (anti-FGFR1 antibody) for metastatic tumors that express FGFR1

  This trial will try OM-RCA-01, an IV antibody given every two weeks, in adults with metastatic cancers whose tumors test positive for FGFR1 and who have progressed after standard treatments.

  Recruiting at 4 sites Phase 1/2 Kidney Cancer Research Bureau · Kazan' and 4 other locations · NCT07292168

• Injecting a viral particle to treat head and neck cancer

  This study is testing a new virus injection to see if it can help treat head and neck cancer in different groups of patients.

  Recruiting Phase 1 VLP Therapeutics · Stanford, California · NCT06736379

• Exploring HPV and Genomic Changes in Head and Neck Cancer

  This study is trying to see how common HPV is in head and neck cancer patients in Bangladesh and what changes it causes in their cells.

  Recruiting Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh · Dhaka, Dhaka Division · NCT06642324

• Treatment of head-neck cancer using RiMO-301, radiotherapy, and a PD-1 inhibitor

  This study is testing a new treatment combining RiMO-301, radiation therapy, and a PD-1 inhibitor to see if it helps people with advanced head and neck cancer feel better and live longer.

  Recruiting Phase 1/2 Coordination Pharmaceuticals, Inc. · Chicago, Illinois · NCT05838729

• Exploring new treatment targets for head and neck cancers

  This study is trying to find out how certain genetic changes and HPV relate to head and neck cancers in patients with oral squamous cell carcinoma to help improve treatment options.

  Recruiting Banaras Hindu University · Varanasi, Uttar Pradesh · NCT05382585

NIH-funded research (8)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• New treatment targets for head and neck cancer in Veterans

  This project looks for ways to block a protein called TMEM16A that helps head and neck cancers grow in Veterans.

  NIH research VA Medical Center · New York, United States · NIH-11471967

• New treatments for head and neck cancer in veterans

  This study is looking at how a specific protein called TMEM16A affects the growth of a type of throat and mouth cancer in veterans, with the goal of finding new ways to stop early signs of cancer from becoming more serious.

  NIH research VA Medical Center · New York, United States · NIH-11218692

• Personalized scheduling for radiation therapy in head and neck cancer

  This study is looking at how to make radiation therapy better for people with head and neck cancers by creating personalized treatment plans that adjust based on how the tumor changes during treatment, helping to reduce side effects and improve results.

  NIH research Rice University · Houston, United States · NIH-11199085

• Personalized treatment planning for head and neck cancer radiation therapy

  This study is working to make radiation therapy better for people with head and neck cancers by creating personalized treatment plans that adjust to changes in their bodies during treatment, helping to reduce side effects and protect healthy tissues.

  NIH research Rice University · Houston, United States · NIH-11198078

• Understanding and Treating Head and Neck Cancer with Ceramide

  This research explores how a natural substance called ceramide can help stop head and neck cancer cells from growing and improve future treatments.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11114057

• New ways to treat head and neck cancer in veterans

  This study is looking at how a certain protein called TMEM16A affects the growth of a type of cancer in veterans, with the hope of finding better treatments for both early and advanced stages of the disease.

  NIH research Veterans Health Administration · Pittsburgh, United States · NIH-10948102

• Personalized treatment planning for head and neck cancer using adaptive radiation therapy

  This study is looking to make radiation therapy for head and neck cancers better by creating personalized treatment plans that adjust based on how your body changes during therapy, helping to target the tumor more effectively while reducing side effects.

  NIH research Rice University · Houston, United States · NIH-10862796

• Understanding the signals that drive head and neck cancer

  This study is looking into how head and neck cancer develops and grows, hoping to find new ways to treat it better by understanding the genetic changes and signals in the cells.

  NIH research Boston University Medical Campus · Boston, United States · NIH-10763417

Related topics

Quick answers

How many Head & Neck Cancer clinical trials are recruiting right now?

23, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 13 countries. The most sites are in China (8 trials), United States (4 trials), Italy (3 trials), Norway (2 trials), Netherlands (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 3, Phase 3: 3, Phase 1/2: 3, Phase 2: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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