Testing a new treatment for mouth sores caused by radiation therapy
Official title: Preclinical assessment of a novel compound for treating radiation-induced oral mucositis
Funded at Sinopia Biosciences, INC. · NIH-10822803 · Data updated 2026-11-12
This study is looking at a new treatment to help prevent and ease the painful mouth sores that many cancer patients get from radiation therapy, using a special compound that has shown promise in early tests.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sinopia Biosciences, INC. NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project start | September 5, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $1,493,635 |
| NIH project number | 2R44DE031464-02 |
| Project ID | NIH-10822803 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients undergoing radiation therapy for head and neck cancers who are at risk of developing oral mucositis.
✕Less likely to help
Patients who are not receiving radiation therapy or those with other types of cancer unrelated to head and neck regions may not benefit from this research.
What this research studies
This research focuses on developing a novel compound to prevent and treat oral mucositis, a painful inflammation and ulceration of the mouth that often occurs in cancer patients undergoing radiation therapy. The study utilizes a computational platform to identify a small molecule that targets specific biological pathways associated with mucositis. Preclinical tests in animal models have shown promising results, indicating that this compound can significantly reduce the duration of mouth sores and may even prevent them altogether. The goal is to provide a safe and effective treatment option for patients suffering from this debilitating side effect.
Why it matters
Potential benefit: If successful, this research could lead to a new treatment that alleviates the pain and complications associated with oral mucositis in cancer patients.
How similar studies have gone: Previous research has shown success in using similar compounds to treat mucositis, but this specific approach is novel and has not yet been tested in clinical settings.
Where this research is happening
-
Sinopia Biosciences, INC.
San Diego, United States Active
Researchers
- Principal investigator: Lloyd, Colton Joseph — Sinopia Biosciences, INC.
- Study coordinator: Lloyd, Colton Joseph
Related research
Other NIH-funded projects on the same topics.
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Understanding how biological sex affects radiation-induced oral mucositis
This grant explores why women and men experience different severity of mouth sores during head and neck cancer radiotherapy and how to tailor treatments to reduce pain and healing time.
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First-in-human topical gel for preventing and treating radiation-induced oral ulcers in cancer patients
A new oral gel applied to the mouth is being tested to prevent and treat painful mouth ulcers caused by cancer radiation therapy, with early safety and dosing data gathered in people.
-
New medicine to prevent or lessen painful mouth sores from radiation
This project develops a potential drug to prevent or shorten painful mouth sores that happen after radiation therapy for head and neck cancer.
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Protecting the mouth from radiation in head and neck cancer
A Duke University-based study looks at how the p53 protein may guard the mouth from radiation-related damage in people with head and neck cancer.
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Prophylactic and therapeutic oral gel to prevent and treat radiation-induced mouth ulcers in cancer patients
A new topical gel shown in animals may prevent or treat painful mouth ulcers caused by cancer radiation therapy, with plans to move toward human testing.
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A new medicine to prevent and treat radiation-related mouth sores
A new oral drug is being developed to prevent or shorten painful mouth sores in people getting radiation to the head and neck.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.