Targeting specific nerves to reduce pain and mouth sores from radiation therapy
Targeting TRPV1-containing nerves for radiation-induced pain and oral mucositis
This study is looking at how to help people with head and neck cancer who experience painful mouth sores and burning pain during radiation therapy, by exploring new ways to ease their discomfort and improve their quality of life.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10950683 on NIH RePORTER |
What this research studies
This research focuses on addressing the pain and oral mucositis that often occur in patients undergoing radiation therapy for head and neck cancer. It aims to investigate the role of TRPV1-containing nerves in these conditions, as many patients report severe burning pain during and after treatment. By developing preclinical models, the research will evaluate new therapeutic options to alleviate pain and improve the quality of life for affected patients. The study will also explore the relationship between nerve density and the severity of symptoms.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients receiving radiation therapy for head and neck cancer who experience pain and oral mucositis.
Not a fit: Patients who are not undergoing radiation therapy or those with other types of cancer unrelated to head and neck may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective pain management strategies for patients undergoing radiation therapy for head and neck cancer.
How similar studies have performed: Previous studies have shown promise in targeting TRPV1 nerves for pain relief, indicating potential for success in this novel approach.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Scheff, Nicole N — University of Pittsburgh at Pittsburgh
- Study coordinator: Scheff, Nicole N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.