Condition

Nonalcoholic Fatty Liver Disease clinical trials and research

• 11Clinical trials
• 29NIH research projects
• 5Countries

Newest Nonalcoholic Fatty Liver Disease clinical trials

All recruiting trials (11)

• Combining genetics, blood, urine, and stool data to predict complications of metabolic syndrome

  The team will try combining genetic, blood, urine, and stool data to see if patterns predict complications in adults with or without metabolic syndrome.

  Recruiting Chang Gung Memorial Hospital · Taoyuan · NCT07248371

• ERCG (clip-and-loop endoscopic gastric reduction) versus optimized lifestyle for weight loss

  This trial will test whether ERCG, a sutureless endoscopic clip-and-loop procedure that reduces stomach volume, helps Chinese adults with BMI 24.0–37.4 kg/m² lose more weight than an optimized lifestyle program.

  Recruiting Beijing 302 Hospital · Beijing, Beijing Municipality and 1 other locations · NCT07237750

• New MRI methods to measure metabolism and predict outcomes in metabolic-associated fatty liver disease

  This project tests whether new MRI techniques can measure body metabolism and help predict disease status and prognosis for people with metabolic-associated fatty liver disease.

  Recruiting Tongji Hospital · Wuhan, Hubei · NCT07149571

• Low‑methoxy pectin for inflammation, gut microbiome, and metabolic health in MASLD

  This tests whether taking daily low‑methoxy pectin for six weeks can reduce inflammation and improve gut bacteria and metabolic markers in adults with MASLD.

  Recruiting at 3 sites University of Nottingham · Nottingham, United Kingdom and 2 other locations · NCT07093346

• Effects of Henagliflozein on liver fat in patients with diabetes and fatty liver disease

  This study is testing if a new diabetes medication called Henagliflozein can help reduce liver fat in people with type 2 diabetes and fatty liver disease.

  Recruiting Phase 4 Zhujiang Hospital · Guangzhou, Guangdong · NCT06449833

• Antiviral therapy for chronic hepatitis B with nonalcoholic fatty liver disease

  This study is testing if a new antiviral treatment can help people with chronic hepatitis B and fatty liver disease clear the virus better than the standard medication.

  Recruiting at 5 sites Phase 4 First Affiliated Hospital of Wenzhou Medical University · Ningbo and 4 other locations · NCT06368882

• Understanding Non-Alcoholic Fatty Liver Disease in Saudi Patients with Type 2 Diabetes

  This study looks at how non-alcoholic fatty liver disease affects Saudi adults with type 2 diabetes over 10 years to see how the disease progresses and what factors might make it worse.

  Recruiting King Saud University · Riyadh, Select A State Or Province · NCT05697991

• Observational study on patients with nonalcoholic fatty liver disease

  This study looks at patients with nonalcoholic fatty liver disease to see how their condition varies and to collect samples for future research.

  Recruiting Xiangya Hospital of Central South University · Changsha, Hunan · NCT05625750

• Assessing liver fat levels in HIV/AIDS patients on different medications

  This study is trying to see how different HIV medications affect liver fat levels in patients living with HIV/AIDS to understand the risk of liver disease.

  Recruiting Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT05330923

• Monitoring chronic hepatitis B patients with fatty liver disease

  This study looks at how chronic hepatitis B affects people who also have fatty liver disease to see if having both conditions leads to more serious liver problems over time.

  Recruiting Humanity and Health Research Centre · Hong Kong, Hong Kong · NCT02863757

• Cohort of obese patients with nonalcoholic fatty liver disease

  This study is trying to find out what causes some obese people with fatty liver disease to develop a more serious condition and to see if there are easier ways to diagnose it.

  Recruiting Maastricht University Medical Center · Maastricht, Limburg · NCT02422238

NIH-funded research (29)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Targeting fatty liver disease in women around pregnancy to improve health

  This grant explores how to identify and help pregnant and postpartum women who are at risk for fatty liver disease to prevent liver problems later.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11385949

• Clinically meaningful research on fatty liver disease in adults and children

  A nationwide effort studying MASLD, the major form of fatty liver disease, to find better ways to identify who is at risk and how to treat it, including kids and adults.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11369254

• NAFLD in PCOS: Do androgens drive liver injury and fatty liver progression?

  Young women with PCOS may face liver disease progression due to high androgen levels, and this research looks at targeted ways to slow or prevent that progression.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11345167

• Ultrasound tests to find and track fatty liver in children

  This project develops easy-to-use ultrasound methods to find and monitor liver fat in children who are overweight or obese.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11326290

• How genes and heavy metals influence fatty liver disease

  This project looks at how a person’s genes and the amounts of metals in their liver together relate to nonalcoholic fatty liver disease (NAFLD).

  NIH research Wayne State University · Detroit, United States · NIH-11306089

• Gm4951 gene and nonalcoholic fatty liver disease (NAFLD)

  Researchers are looking at whether changes in the Gm4951 gene affect how much fat builds up in the liver for people with nonalcoholic fatty liver disease.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11248812

• Investigating the link between fatty liver disease and preeclampsia risk in pregnant women

  This study is looking at how nonalcoholic fatty liver disease might increase the chances of developing preeclampsia in overweight and obese pregnant women, with the goal of finding ways to keep moms and babies healthier during pregnancy.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11248108

• Preventing and treating fatty liver during pregnancy and after childbirth

  This project screens pregnant and postpartum women for fatty liver using blood tests and non-invasive tools to track liver changes that could affect their long-term health.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11228037

• Understanding and Treating Fatty Liver Disease

  This project aims to find better ways to understand, diagnose, and treat fatty liver disease, which affects many adults and children.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11166644

• Better liver imaging for nonalcoholic fatty liver disease

  This research is creating new MRI techniques to check for liver inflammation and damage in people with nonalcoholic fatty liver disease without needing a biopsy.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11135407

• How genes and heavy metals affect liver disease

  This study is looking at how certain genes and heavy metals in the liver might affect people with nonalcoholic fatty liver disease (NAFLD), which is a common condition with no approved treatments yet, to help find better ways to diagnose and manage it.

  NIH research Wayne State University · Detroit, United States · NIH-11128507

• Using ultrasound to diagnose fatty liver disease in children.

  This study is working to help kids with nonalcoholic fatty liver disease by creating better ultrasound tools to spot liver fat early, so they can get the care they need sooner.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11124834

• How Androgens Affect Liver Health in Women with PCOS

  This project explores how elevated androgen levels in women with Polycystic Ovary Syndrome (PCOS) may lead to liver damage and the progression of fatty liver disease.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11115746

• How vinyl chloride affects the risk of severe liver disease

  This study is looking at how a chemical called vinyl chloride, which we can find in our environment, might increase the risk of nonalcoholic fatty liver disease (NAFLD), especially in people who are overweight or have metabolic issues, and it hopes to find new ways to help treat this liver condition.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11085125

• Understanding how immune cells contribute to liver disease

  This study is looking at how immune cells move to the liver in people with nonalcoholic fatty liver disease (NAFLD) as it changes to a more serious condition called nonalcoholic steatohepatitis (NASH), with the hope of finding new ways to help treat liver problems caused by inflammation.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11084388

• Investigating how kisspeptin signaling affects liver fat accumulation in nonalcoholic fatty liver disease.

  This study is looking at how a substance called kisspeptin affects the liver and its role in nonalcoholic fatty liver disease (NAFLD), which many adults have, to find new ways to help treat this condition and its related issues.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11083704

• Helping Mexican and Central-American patients with fatty liver disease improve their health

  This study is all about helping Mexican and Central-American patients with nonalcoholic fatty liver disease (NAFLD) by finding out what makes it hard for them to change their eating and exercise habits, and then creating a friendly program to support them in losing weight and improving their liver health.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11082309

• Investigating a gene's role in nonalcoholic fatty liver disease

  This study is looking at how a specific gene affects fat buildup in the liver of mice on a high-fat diet, which helps researchers find new ways to treat nonalcoholic fatty liver disease (NAFLD) in people.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-10997332

• Investigating how dietary cholesterol affects liver disease through gut bacteria

  This study is looking at how the food we eat, especially cholesterol in a Western diet, affects liver health and the role of gut bacteria in this process, which could help find new ways to prevent or treat liver diseases like NAFLD and NASH.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-10948915

• Using ultrasound to detect early signs of fatty liver disease

  This study is testing a new ultrasound method to help find nonalcoholic fatty liver disease early, making it easier and cheaper for patients to get checked for liver health before serious problems develop.

  NIH research Texas Engineering Experiment Station · College Station, United States · NIH-10933143

• The impact of androgens on liver health in women with Polycystic Ovary Syndrome.

  This study is looking at how high levels of certain hormones in women with PCOS might harm their liver and lead to fatty liver disease, and it hopes to find ways to help improve liver health for those affected.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-10914973

• Investigating how DNA damage affects liver health in children with fatty liver disease

  This study is looking at how a specific gene might affect liver health in children with nonalcoholic fatty liver disease, helping us understand why kids can get sicker faster than adults and how we can better support their recovery.

  NIH research Albert Einstein College of Medicine · Bronx, United States · NIH-10894167

• A new system to study liver disease and improve clinical trials for patients with fatty liver disease

  This study is creating a special model of the liver using cells from patients to help us learn more about nonalcoholic fatty liver disease (NAFLD) and improve new treatments, so that people with this condition can have better options for care.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10868453

• Improving women's health by targeting liver disease during pregnancy

  This study is looking at how pregnancy can affect liver health in women, especially those at risk for nonalcoholic fatty liver disease (NAFLD) and its more serious form, and it aims to find early signs of these conditions through simple tests during pregnancy to help improve health for moms and their babies.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-10858545

• Investigating the role of a specific protein in liver disease related to aging

  This study is looking at how a protein called HUWE1 affects nonalcoholic fatty liver disease (NAFLD) in older adults, with the goal of finding new ways to help manage or prevent this condition.

  NIH research Kent State University · Kent, United States · NIH-10834220

• Targeted treatment for fatty liver disease using genetic medicine

  This study is testing a new genetic treatment for people with nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) who have a specific gene mutation, to see if it can help reduce fat in the liver and improve their health.

  NIH research Wayne State University · Detroit, United States · NIH-10832053

• Understanding the genetic factors behind nonalcoholic fatty liver disease.

  This study is looking at how our genes might affect nonalcoholic fatty liver disease (NAFLD) by using special cells from patients to see how certain genetic differences can lead to fat buildup in the liver, helping us learn more about why some people may have more severe cases of this condition.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-10804636

• Understanding liver disease related to nuclear lamins

  This study is looking at how certain proteins in our cells might affect nonalcoholic fatty liver disease (NAFLD) by using zebrafish to better understand the disease and find new ways to treat it.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-10771130

• Reducing iron levels to improve diabetes and liver health

  This study is looking at how high iron levels in the body might be linked to type 2 diabetes and fatty liver disease, and it will see if lowering iron through a simple blood donation can help improve blood sugar and liver health for people with too much iron.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-10761794

Related topics

Quick answers

How many Nonalcoholic Fatty Liver Disease clinical trials are recruiting right now?

11, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 5 countries. The most sites are in China (7 trials), Netherlands (1 trial), United Kingdom (1 trial), Saudi Arabia (1 trial), Taiwan (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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