Understanding liver disease related to nuclear lamins
Official title: Nuclear lamins and the hepatocyte nuclear envelope in nonalcoholic fatty liver disease
Funded at University of Michigan at Ann Arbor · NIH-10771130 · Data updated 2026-11-12
This study is looking at how certain proteins in our cells might affect nonalcoholic fatty liver disease (NAFLD) by using zebrafish to better understand the disease and find new ways to treat it.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | March 3, 2020 |
| Project end | January 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $167,400 |
| NIH project number | 5K08DK120948-05 |
| Project ID | NIH-10771130 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with nonalcoholic fatty liver disease, particularly those with genetic mutations affecting nuclear lamina components.
✕Less likely to help
Patients with liver diseases unrelated to nuclear lamins or those without NAFLD may not benefit from this research.
What this research studies
This research investigates the role of nuclear lamins in nonalcoholic fatty liver disease (NAFLD) using advanced techniques in genomics and bioinformatics. The principal investigator, Dr. Graham Brady, aims to uncover the mechanisms behind NAFLD by studying a unique model organism, zebrafish, which allows for detailed observation of liver function and disease progression. The project combines clinical expertise in hepatology with innovative research methodologies to enhance our understanding of this prevalent liver condition. By identifying genetic factors and cellular processes involved in NAFLD, the research seeks to pave the way for new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from nonalcoholic fatty liver disease.
How similar studies have gone: Previous research has shown promise in understanding liver diseases through genetic and cellular studies, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Brady, Graham F. — University of Michigan at Ann Arbor
- Study coordinator: Brady, Graham F.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.