Investigating how dietary cholesterol affects liver disease through gut bacteria
The role of dietary cholesterol in Nonalcoholic fatty liver disease through the action of gut microbiota
This study is looking at how the food we eat, especially cholesterol in a Western diet, affects liver health and the role of gut bacteria in this process, which could help find new ways to prevent or treat liver diseases like NAFLD and NASH.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-10948915 on NIH RePORTER |
What this research studies
This research explores the connection between dietary cholesterol and Nonalcoholic fatty liver disease (NAFLD), focusing on how gut microbiota may influence this relationship. By examining the effects of a Western diet on gut bacteria, the study aims to uncover mechanisms that contribute to the development of NAFLD and its more severe form, Nonalcoholic steatohepatitis (NASH). The research utilizes animal models to analyze changes in gut microbial populations and their potential role in liver disease progression. Understanding these interactions could lead to new dietary strategies to prevent or treat NAFLD/NASH.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for or diagnosed with Nonalcoholic fatty liver disease, particularly those with dietary habits high in cholesterol.
Not a fit: Patients with liver disease caused by factors other than diet, such as viral hepatitis or alcohol consumption, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new dietary recommendations or interventions that help prevent or manage Nonalcoholic fatty liver disease.
How similar studies have performed: While there are many ongoing studies related to NAFLD, this specific investigation into the role of dietary cholesterol and gut microbiota is relatively novel and has not been extensively tested.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Hermanson, Jake Brenner — University of Wisconsin-Madison
- Study coordinator: Hermanson, Jake Brenner
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.