Investigating how kisspeptin signaling affects liver fat accumulation in nonalcoholic fatty liver disease.
Official title: Hepatic fat accumulation in nonalcoholic fatty liver disease: critical regulation by kisspeptin signaling
Funded at Rutgers Biomedical and Health Sciences · NIH-11083704 · Data updated 2026-11-12
This study is looking at how a substance called kisspeptin affects the liver and its role in nonalcoholic fatty liver disease (NAFLD), which many adults have, to find new ways to help treat this condition and its related issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project start | April 30, 2022 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $473,236 |
| NIH project number | 5R01DK129870-04 |
| Project ID | NIH-11083704 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults with nonalcoholic fatty liver disease or those at risk due to obesity or metabolic disorders.
✕Less likely to help
Patients with liver disease due to alcohol consumption or other non-metabolic causes may not benefit from this research.
What this research studies
This research focuses on understanding the role of kisspeptin signaling in the liver and its impact on nonalcoholic fatty liver disease (NAFLD), a condition that affects a significant portion of adults. The study examines how kisspeptin interacts with liver cells and regulates fat accumulation, particularly in the context of obesity and high-fat diets. By using mouse models, researchers will explore the molecular mechanisms that lead to fatty liver and its progression to more severe liver conditions. The ultimate goal is to identify potential therapeutic targets for treating NAFLD and its complications.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for nonalcoholic fatty liver disease, potentially improving liver health for many patients.
How similar studies have gone: Previous research has shown promising results in understanding the role of signaling pathways in liver diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Rutgers Biomedical and Health Sciences
Newark, United States Active
Researchers
- Principal investigator: Bhattacharya, Moshmi M — Rutgers Biomedical and Health Sciences
- Study coordinator: Bhattacharya, Moshmi M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.