Condition

MASLD clinical trials and research

• 19Clinical trials
• 16NIH research projects
• 15Countries

Newest MASLD clinical trials

All recruiting trials (19)

• Reset-INSPIRE: See if CGM can reveal insulin sensitivity in people at risk for MASLD

  This study tests whether real-time CGM data can accurately reflect insulin sensitivity in adults without diabetes who are at risk for MASLD.

  Recruiting National University Health System, Singapore · Singapore, Singapore · NCT07861191

• ALN-CIDEB in adults with MASLD to see if it helps the liver

  This study tests whether ALN-CIDEB can help adults with MASLD and its liver damage compared to placebo.

  Recruiting at 4 sites Phase 3 Regeneron Pharmaceuticals · Miami, Florida and 3 other locations · NCT07854782

• Peanut intake and liver health in adults with MASLD

  This study tests whether adding peanuts to daily meals for 12 weeks can improve liver markers and metabolic health in adults with MASLD.

  Recruiting Henry Ford Health System · Detroit, Michigan · NCT07646197

• Guided electronic tools to help clinicians manage MASLD

  Aimed at testing whether an electronic decision support tool used in primary care and specialty settings can help clinicians better manage MASLD in adults.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT07382349

• Liver gene response to IV glucose during bariatric surgery in obese people with and without MASLD.

  This trial will test whether giving sugar through a vein changes liver gene activity during bariatric surgery in people with obesity who do or do not have MASLD.

  Recruiting Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam, North Holland · NCT07326865

• Low‑methoxy pectin for inflammation, gut microbiome, and metabolic health in MASLD

  This tests whether taking daily low‑methoxy pectin for six weeks can reduce inflammation and improve gut bacteria and metabolic markers in adults with MASLD.

  Recruiting at 3 sites University of Nottingham · Nottingham, United Kingdom and 2 other locations · NCT07093346

• Digital early-warning system to predict acute lung injury after major liver surgery

  This study will try a machine-learning based warning tool to predict early acute lung injury in adults having major liver surgery.

  Recruiting at 4 sites Beijing Tsinghua Chang Gung Hospital · Beijing, Beijing Municipality and 3 other locations · NCT07070362

• Tirzepatide's effect on liver health in obese patients

  This study tests if tirzepatide can improve liver health in obese patients who have a condition called MASLD.

  Recruiting Early Phase 1 University of New Mexico · Albuquerque, New Mexico · NCT06934642

• Assessing heart function in patients with liver cirrhosis undergoing TIPSS placement

  This study is testing how heart function changes in patients with severe liver cirrhosis who are getting a specific procedure called TIPSS to see if it affects their heart health over the next year.

  Recruiting Jena University Hospital · Jena, Thuringia · NCT06814990

• Using advanced ultrasound to evaluate liver disease in children

  This study is testing new ultrasound methods to see if they can help doctors better detect and monitor liver fat in children at risk for liver disease.

  Recruiting University of California, San Diego · La Jolla, California · NCT06706856

• Healthy Nordic diet's effects on heart disease

  This study is testing if following a Healthy Nordic diet can help people with coronary heart disease improve their heart health over 18 months.

  Recruiting Uppsala University · Uppsala · NCT06701968

• Improving care for Veterans with non-alcoholic fatty liver disease

  This study tests a new way to help Veterans with non-alcoholic fatty liver disease by using a structured plan to improve diagnosis and treatment compared to regular care.

  Recruiting VA Office of Research and Development · Houston, Texas · NCT06671886

• Ultraportable Hepatoscope ultrasound for measuring liver fat in MASLD/MASH

  The Hepatoscope device will be tested to see if it can measure liver fat accurately in adults with MASLD/MASH compared with MRI-PDFF.

  Recruiting at 2 sites E-Scopics · Angers and 2 other locations · NCT06661655

• Endoscopic ultrasound shear wave elastography for measuring liver fibrosis

  This study will test whether endoscopic ultrasound shear wave elastography and attenuation imaging can estimate liver fibrosis compared with biopsy and FibroScan in adults with suspected MASLD or MASH.

  Recruiting at 3 sites Olympus Corporation of the Americas · Newport Beach, California and 2 other locations · NCT06592820

• Digoxin for NASH with stage 2–3 fibrosis

  This trial will see if taking once-daily digoxin helps clear NASH and reduce liver scarring in adults with biopsy-confirmed NASH and stage 2–3 fibrosis.

  Recruiting at 2 sites Phase 2 Yale University · New Haven, Connecticut and 1 other locations · NCT06588699

• Effects of a high fructose diet on gut health and metabolism

  This study is testing how eating a high fructose diet affects gut health and metabolism in people who may struggle to digest fructose.

  Recruiting Icahn School of Medicine at Mount Sinai · New York, New York · NCT06329544

• Endoscopic sleeve gastroplasty for people with obesity and MASH

  This study will test whether endoscopic sleeve gastroplasty plus lifestyle changes helps adults with obesity and MASH lose weight and improve liver health compared with lifestyle changes alone.

  Recruiting at 2 sites Brigham and Women's Hospital · Boston, Massachusetts and 1 other locations · NCT06138821

• Screening patients at risk for liver disease in Europe

  This study is trying to find out if screening high-risk patients in Europe for liver disease using simple tests can help doctors identify and better understand conditions like metabolic dysfunction-associated steatotic liver disease.

  Recruiting at 6 sites Julius Clinical · Brussels, Vlaams-brabant and 12 other locations · NCT05651724

• Non-invasive tool to predict fatty liver disease

  This study is testing a new, non-invasive tool to see if it can help identify fatty liver disease in healthy people and those already diagnosed with it.

  Recruiting Richmond Pharmacology Limited · London, London · NCT04873258

NIH-funded research (16)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Them1’s role in fat metabolism and MASLD progression

  Aims to understand how a fat-regulating protein (Them1) affects energy use in fat and liver, and how this could contribute to MASLD in people who are overweight.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-11591395

• Understanding MASLD progression to MASH and liver cancer in Alaska Native communities

  A patient-facing overview of a study that looks at why a common liver disease progresses to more serious conditions in Alaska Native and American Indian people.

  NIH research Alaska Native Tribal Health Consortium · Anchorage, United States · NIH-11529997

• Pediatric MASLD: a blood test to detect liver disease progression in kids

  A child-friendly blood test is being developed to spot liver disease progression in kids with MASLD without needing biopsies.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11442484

• Growth Hormone and DNA Repair in Children's MASLD outcomes

  A small, patient-friendly study will explore how growth hormone and the ATM DNA repair pathway affect liver health in children with MASLD.

  NIH research Albert Einstein College of Medicine · Bronx, United States · NIH-11440016

• Isocaloric navy bean substitution for MASLD with fibrosis

  A small, patient-friendly trial tests whether swapping in navy beans for some daily calories can help adults with MASLD and liver fibrosis without changing total calories.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11433609

• S100A9+ immune cells driving liver scarring in MASLD/MASH

  Affects people with MASLD/MASH may benefit from a better understanding of how certain immune cells contribute to liver fibrosis and how to stop it.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11429726

• Multi-ancestry genetic study of MASLD with follow-up tests

  A large genetics study will look for liver disease risk genes across diverse populations and follow up with functional tests to understand how these genes affect MASLD.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11416719

• LysoGen: a targeted liver therapy to boost lysosome health in MASLD

  A new medicine idea aims to restore normal lysosome acidity in the liver to help people with MASLD.

  NIH research Boston University (Charles River Campus) · Boston, United States · NIH-11382288

• Early detection of liver cancer risk in people with cirrhosis and MASLD

  A small research grant to explore better ways to find liver cancer early among people with cirrhosis and MASLD so they can get timely care.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11356187

• How the MARCH6 protein controls liver fat in MASLD

  This project looks at whether restoring the liver protein MARCH6 can reduce harmful fat buildup in people with metabolic dysfunction-associated steatotic liver disease (MASLD).

  NIH research Temple Univ of the Commonwealth · Philadelphia, United States · NIH-11346655

• Regulatory T cells and their role in MASLD progression

  This grant studies how regulatory T cells behave in the liver of adults with MASLD to understand why the disease progresses and what might help treat it.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11339017

• Restoring lysosome acidity to help fatty liver (MASLD)

  Researchers are developing an acid-releasing therapy to help liver cells clear fat buildup in people with metabolic-dysfunction associated steatotic liver disease (MASLD).

  NIH research Boston University (Charles River Campus) · Boston, United States · NIH-11195154

• Understanding Them1's Role in Fatty Liver Disease

  This research explores how a protein called Them1 contributes to fatty liver disease when people eat too much.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11189816

• Investigating the role of a protein in liver disease and metabolic disorders

  This study is looking at how a protein called SUN1 might affect liver health in people with metabolic dysfunction-associated steatotic liver disease (MASLD), and we're inviting patients to help by sharing genetic samples to see how different versions of this protein could play a role in this condition.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11057704

• Improving liver health by restoring lysosomal function

  This study is testing a new treatment for people with metabolic dysfunction-associated steatotic liver disease (MASLD) that helps improve liver cell function by making sure they can break down and recycle waste better, and it will be given through an IV directly to the liver.

  NIH research Boston University (Charles River Campus) · Boston, United States · NIH-11029527

• Investigating liver cancer risk factors in Native Hawaiians compared to US whites

  This study is looking at why Native Hawaiians might have a higher risk of liver cancer compared to white Americans, especially in people with a liver condition called MASLD, and it aims to understand how lifestyle, culture, and the environment affect this risk while also exploring the role of gut health and the immune

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11014249

Related topics

Quick answers

How many MASLD clinical trials are recruiting right now?

19, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 15 countries. The most sites are in United States (10 trials), United Kingdom (2 trials), France (2 trials), Germany (2 trials), Netherlands (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Early Phase 1: 1, Phase 2: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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