Condition

Nephrotic Syndrome clinical trials and research

• 18Clinical trials
• 16NIH research projects
• 10Countries

Newest Nephrotic Syndrome clinical trials

All recruiting trials (18)

• Smartphone app to help follow the 2024 KDIGO chronic kidney disease guidelines

  This project will test whether a smartphone app helps young adults (ages 16–29) with chronic kidney disease follow the 2024 KDIGO guideline recommendations.

  Recruiting at 2 sites St. James's Hospital, Ireland · Dublin and 1 other locations · NCT07561957

• SGLT2 inhibitors added to standard care in adult primary nephrotic syndrome

  This trial tests whether adding dapagliflozin or empagliflozin to standard treatment helps reduce protein in urine for adults with primary nephrotic syndrome.

  Recruiting Phase 2/3 Mansoura University · Al Mansurah, Dakahlia Governorate · NCT07214818

• Atacicept for multiple autoimmune glomerular diseases

  This will test whether weekly injections of atacicept can lower protein in the urine and help preserve kidney function in people aged 10 and older with IgA nephropathy, primary membranous nephropathy, or nephrotic syndromes such as MCD and FSGS.

  Recruiting Phase 2 Vera Therapeutics, Inc. · Brisbane, California · NCT06983028

• Multitarget approach for primary podocytopathies

  This project will test whether a lab cell culture can find a factor in the blood that causes proteinuria in people with primary podocytopathies and whether a combined therapy can block that factor in vitro.

  Recruiting at 2 sites Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico · Milan and 1 other locations · NCT06718894

• Follow-up on Rituximab treatment for children's nephrotic syndrome

  This study looks at how well rituximab works and its safety for children with hard-to-treat nephrotic syndrome by reviewing their past treatment data.

  Recruiting The First Affiliated Hospital of Xiamen University · Xiamen, Fujian · NCT06530004

• Investigating the role of a protein in kidney damage related to nephrotic syndrome

  This study is trying to see if a protein called PCSK9 is linked to kidney damage and high cholesterol in people with nephrotic syndrome.

  Recruiting Kolding Sygehus · Kolding · NCT06373913

• Anti-nephrin antibodies in people with idiopathic nephrotic syndrome

  This project tests whether adults with idiopathic nephrotic syndrome (including MCD, FSGS, and post-transplant FSGS relapse) have circulating anti-nephrin autoantibodies compared with people with primary membranous nephropathy.

  Recruiting Mario Negri Institute for Pharmacological Research · Ranica, BG · NCT06334692

• Registry and biobank for resistant nephrotic syndrome treatment responses

  This study is collecting information from patients with resistant nephrotic syndrome to see how different treatments work and to help find better options for the future.

  Recruiting Medical University of Vienna · Vienna · NCT06162546

• Monitoring steroid diabetes in kidney disease patients

  This study is tracking patients with nephrotic syndrome who are starting steroid treatment to see if they develop high blood sugar and to help manage it early on.

  Recruiting Zhejiang Provincial People's Hospital · Hangzhou, Zhejiang · NCT06161701

• Using ketoanalogues to prevent muscle loss in nephrotic syndrome

  This study is testing if adding a special supplement called ketoanalogues to a medium protein diet can help adults with nephrotic syndrome keep their muscle mass and function.

  Recruiting Phase 3 Military Institute od Medicine National Research Institute · Warsaw, Masovian District · NCT05716880

• Exploring experiences of patients and parents dealing with swelling from Nephrotic Syndrome

  This study talks to patients and parents about their experiences with swelling from Nephrotic Syndrome to help create better ways to measure how new treatments work.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT05505500

• Mobile app to manage swelling in kidney patients

  This study tests a mobile app that helps kidney patients manage swelling by adjusting their diuretic medication and tracking their daily health data.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT04759274

• From Immune System and Kidney Cell Damage in Nephrotic Syndrome

  We’re testing how immune system changes and podocyte (kidney cell) damage relate to first episodes of nephrotic syndrome in both kids and adults.

  Recruiting at 2 sites Centre Hospitalier Universitaire de Nice · Nice and 1 other locations · NCT04174066

• Combining belimumab and rituximab for treating primary membranous nephropathy

  This study is testing if combining two medications, belimumab and rituximab, can help adults with primary membranous nephropathy feel better and achieve remission more effectively than using rituximab alone.

  Recruiting at 20 sites Phase 2 National Institute of Allergy and Infectious Diseases (NIAID) · Birmingham, Alabama and 19 other locations · NCT03949855

• Registration system for nephrotic syndrome patients in China

  This study is creating a database for nephrotic syndrome patients in China to track their health and treatment responses over time to improve care and understanding of the condition.

  Recruiting Sun Yat-sen University · Guangzhou, Guangdong · NCT03001934

• Longitudinal study of childhood nephrotic syndrome

  This study looks at children with nephrotic syndrome to see how genetics, blood tests, and environmental factors affect the condition and its progression over time.

  Recruiting at 4 sites The Hospital for Sick Children · Brampton, Ontario and 3 other locations · NCT01605266

• Combining Rituximab and Cyclosporine for Membranous Nephropathy

  This study tests if combining two medications, rituximab and cyclosporine, can help people with membranous nephropathy improve their kidney function and reduce protein in their urine.

  Recruiting at 2 sites Phase 2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland and 1 other locations · NCT00977977

• Observing kidney diseases related to the immune system

  This study is trying to learn more about kidney diseases caused by the immune system in patients to find better treatments and understand how these conditions develop.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT00001979

NIH-funded research (16)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Whole genome sequencing to uncover molecular causes in nephrotic syndrome

  A study to map the genetic and molecular factors behind nephrotic syndrome and related kidney diseases to help diagnose and guide future treatments for patients.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11447299

• Sodium-related edema in nephrotic syndrome and ANGPTL4

  A physician-scientist group is studying how a protein called ANGPTL4 may drive skin edema in nephrotic syndrome, with experiments in rodents and tests on human ANGPTL4 fragments.

  NIH research Rush University Medical Center · Chicago, United States · NIH-11431977

• Immune-driven tubulointerstitial injury in pediatric nephrotic syndrome

  A physician-scientist aims to understand how immune processes cause kidney tissue damage in children with difficult-to-treat nephrotic syndrome.

  NIH research Lurie Children's Hospital of Chicago · Chicago, United States · NIH-11352792

• Hodgkin lymphoma–linked nephrotic syndrome and kidney injury

  This project looks at how Hodgkin lymphoma may cause nephrotic syndrome by changing a kidney gene and exposing kidney cells to lymphoma-related substances.

  NIH research Rush University Medical Center · Chicago, United States · NIH-11251265

• Targeting calcineurin regulators for better diagnostics and treatments for nephrotic syndrome

  This work looks at whether proteins that control calcineurin can be used to make better tests and more precise treatments for people with nephrotic syndrome.

  NIH research Duke University · Durham, United States · NIH-11248746

• Investigating the role of a specific protein in childhood kidney disease

  This study is looking at how a protein called CD93 might affect kidney health in children with Idiopathic Nephrotic Syndrome, and by examining blood and urine samples, researchers hope to find clues that could help doctors better understand and treat this condition.

  NIH research Research Inst Nationwide Children's Hosp · Columbus, United States · NIH-11120939

• Improving how we measure symptoms for nephrotic syndrome

  This project aims to create better ways to measure how patients with nephrotic syndrome experience symptoms like fluid overload, making it easier to understand how new treatments are working.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11082524

• Investigating kidney issues caused by Hodgkin's lymphoma

  This study is looking at how Hodgkin's lymphoma might cause kidney problems called nephrotic syndrome, and it's for patients who have either condition, as researchers want to find new ways to help them feel better.

  NIH research Rush University Medical Center · Chicago, United States · NIH-11025226

• Investigating how calcineurin pathways can help diagnose and treat nephrotic syndrome

  This study is looking into the genetic factors that cause nephrotic syndrome and other kidney diseases to find easier ways to diagnose and treat these conditions, helping patients feel better and manage their health more effectively.

  NIH research Duke University · Durham, United States · NIH-11013317

• Improving treatment choices for children with nephrotic syndrome from diverse backgrounds

  This study is all about helping families of children with nephrotic syndrome, especially those from diverse backgrounds, make better choices about their treatment by improving communication with doctors and understanding their experiences.

  NIH research Emory University · Atlanta, United States · NIH-10978376

• Using non-invasive nerve stimulation to treat nephrotic syndrome in children

  This study is looking at a new, gentle way to help children with nephrotic syndrome who often have flare-ups or don’t get better with steroids, using a method that stimulates a nerve in the ear to help calm their immune system and reduce inflammation.

  NIH research Feinstein Institute for Medical Research · Manhasset, United States · NIH-10896271

• Understanding genetic risks in kidney disease and transplant outcomes

  This study is looking at how certain genes, especially those related to the immune system, might affect people with primary nephrotic syndrome and how they respond to treatments like kidney transplants, so we can better understand the condition and improve care for patients.

  NIH research Duke University · Durham, United States · NIH-10848358

• Investigating the role of kidney PCSK9 in nephrotic syndrome

  This study is looking at how a protein called PCSK9 affects cholesterol levels in the kidneys of people with nephrotic syndrome, to help find better ways to spot and treat high cholesterol in these patients.

  NIH research Rush University Medical Center · Chicago, United States · NIH-10750954

• Investigating genetic causes of nephrotic syndrome

  This study is looking at the genes that might cause primary nephrotic syndrome, a kidney condition that makes you lose a lot of protein in your urine, to help find better ways to understand and treat it for patients like you.

  NIH research Boston Children's Hospital · Boston, United States · NIH-10696083

• A mobile app to help manage childhood nephrotic syndrome

  This study is testing a helpful mobile app called UrApp that aims to support families in managing childhood nephrotic syndrome, making it easier for caregivers to take care of their kids with this kidney condition.

  NIH research Emory University · Atlanta, United States · NIH-10655360

• Noninvasive management of kidney disease in children

  This study is testing a new, gentle way to check how well kidneys are working in kids with nephrotic syndrome, using tiny microneedles to take samples from the skin instead of drawing blood, making it easier and less stressful for them.

  NIH research Washington University · Saint Louis, United States · NIH-10593497

Related topics

Quick answers

How many Nephrotic Syndrome clinical trials are recruiting right now?

18, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 10 countries. The most sites are in United States (6 trials), China (3 trials), Italy (2 trials), Austria (1 trial), France (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 2/3: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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