Investigating kidney issues caused by Hodgkin's lymphoma
Official title: Hodgkin’s Lymphoma-induced Nephrotic Syndrome
Funded at Rush University Medical Center · NIH-11025226 · Data updated 2026-11-12
This study is looking at how Hodgkin's lymphoma might cause kidney problems called nephrotic syndrome, and it's for patients who have either condition, as researchers want to find new ways to help them feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rush University Medical Center NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | January 1, 2025 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $343,650 |
| NIH project number | 1R01DK141612-01 |
| Project ID | NIH-11025226 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adolescents and young adults diagnosed with Hodgkin's lymphoma who are experiencing symptoms of nephrotic syndrome.
✕Less likely to help
Patients with Hodgkin's lymphoma who do not develop nephrotic syndrome or those with other unrelated kidney conditions may not benefit from this research.
What this research studies
This research focuses on understanding how Hodgkin's lymphoma can lead to nephrotic syndrome, a serious kidney condition. It examines the role of specific tumor cells that release proteins and cytokines into the bloodstream, which may affect kidney function. The study utilizes advanced techniques, including CRISPR/Cas9 gene editing, to replicate and analyze the genetic changes associated with this condition in laboratory settings. By studying these mechanisms, the research aims to uncover potential therapeutic targets for patients affected by both Hodgkin's lymphoma and nephrotic syndrome.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for patients suffering from kidney complications related to Hodgkin's lymphoma.
How similar studies have gone: Previous research has shown promising results in understanding the genetic factors involved in kidney diseases related to cancer, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Rush University Medical Center
Chicago, United States Active
Researchers
- Principal investigator: Molina Jijon, Eduardo — Rush University Medical Center
- Study coordinator: Molina Jijon, Eduardo
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.