Hodgkin lymphoma–linked nephrotic syndrome and kidney injury
Hodgkin’s Lymphoma-induced Nephrotic Syndrome
['FUNDING_R01'] · RUSH UNIVERSITY MEDICAL CENTER · NIH-11251265
This project looks at how Hodgkin lymphoma may cause nephrotic syndrome by changing a kidney gene and exposing kidney cells to lymphoma-related substances.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RUSH UNIVERSITY MEDICAL CENTER (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-11251265 on ClinicalTrials.gov |
What this research studies
If I have Hodgkin lymphoma, this work aims to find why a small number of people develop nephrotic syndrome. Researchers will analyze Hodgkin Reed–Sternberg cell lines and patient samples to look for a ZHX2 genetic change and the proteins those cancer cells release. They will use CRISPR to reproduce the genetic change in human kidney cells and test effects of lymphoma cell secretions in mouse models to see whether these factors cause protein leakage from the kidney. The team will link lab findings back to samples from Hodgkin patients who developed nephrotic syndrome to better understand the cause.
Who could benefit from this research
Good fit: People with Hodgkin lymphoma—especially adolescents and young adults—or those with Hodgkin lymphoma who have new or worsening proteinuria would be the most relevant candidates.
Not a fit: People who do not have Hodgkin lymphoma or any kidney protein problems are unlikely to receive direct benefit from this work.
Why it matters
Potential benefit: If successful, this could identify markers that predict which Hodgkin lymphoma patients are at risk for nephrotic syndrome and point to ways to prevent or treat the kidney injury.
How similar studies have performed: Previous work has linked ZHX2 defects to minimal change disease and animal models show cytokine-driven albuminuria, but tying a specific Hodgkin cell genetic insertion to human nephrotic syndrome is a new direction.
Where this research is happening
CHICAGO, UNITED STATES
- RUSH UNIVERSITY MEDICAL CENTER — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MOLINA JIJON, EDUARDO — RUSH UNIVERSITY MEDICAL CENTER
- Study coordinator: MOLINA JIJON, EDUARDO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.