Hodgkin lymphoma–linked nephrotic syndrome and kidney injury
Official title: Hodgkin’s Lymphoma-induced Nephrotic Syndrome
Funded at Rush University Medical Center · NIH-11251265 · Data updated 2026-11-12
This project looks at how Hodgkin lymphoma may cause nephrotic syndrome by changing a kidney gene and exposing kidney cells to lymphoma-related substances.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rush University Medical Center NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | January 1, 2025 |
| Project end | November 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $343,650 |
| NIH project number | 5R01DK141612-02 |
| Project ID | NIH-11251265 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with Hodgkin lymphoma—especially adolescents and young adults—or those with Hodgkin lymphoma who have new or worsening proteinuria would be the most relevant candidates.
✕Less likely to help
People who do not have Hodgkin lymphoma or any kidney protein problems are unlikely to receive direct benefit from this work.
What this research studies
If I have Hodgkin lymphoma, this work aims to find why a small number of people develop nephrotic syndrome. Researchers will analyze Hodgkin Reed–Sternberg cell lines and patient samples to look for a ZHX2 genetic change and the proteins those cancer cells release. They will use CRISPR to reproduce the genetic change in human kidney cells and test effects of lymphoma cell secretions in mouse models to see whether these factors cause protein leakage from the kidney. The team will link lab findings back to samples from Hodgkin patients who developed nephrotic syndrome to better understand the cause.
Why it matters
Potential benefit: If successful, this could identify markers that predict which Hodgkin lymphoma patients are at risk for nephrotic syndrome and point to ways to prevent or treat the kidney injury.
How similar studies have gone: Previous work has linked ZHX2 defects to minimal change disease and animal models show cytokine-driven albuminuria, but tying a specific Hodgkin cell genetic insertion to human nephrotic syndrome is a new direction.
Where this research is happening
-
Rush University Medical Center
Chicago, United States Active
Researchers
- Principal investigator: Molina Jijon, Eduardo — Rush University Medical Center
- Study coordinator: Molina Jijon, Eduardo
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.