Investigating the role of kidney PCSK9 in nephrotic syndrome
Official title: Kidney PCSK9 in nephrotic syndrome
Funded at Rush University Medical Center · NIH-10750954 · Data updated 2026-11-12
This study is looking at how a protein called PCSK9 affects cholesterol levels in the kidneys of people with nephrotic syndrome, to help find better ways to spot and treat high cholesterol in these patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rush University Medical Center NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | January 1, 2021 |
| Project end | December 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $331,584 |
| NIH project number | 5R01DK126926-04 |
| Project ID | NIH-10750954 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with nephrotic syndrome who experience elevated cholesterol levels.
✕Less likely to help
Patients without nephrotic syndrome or those who do not have issues with cholesterol levels may not benefit from this research.
What this research studies
This research focuses on understanding how PCSK9, a protein involved in cholesterol regulation, is expressed in the kidneys of patients with nephrotic syndrome. The study aims to explore the molecular mechanisms that lead to high cholesterol levels in these patients, particularly how PCSK9 secreted from kidney cells contributes to this condition. By analyzing kidney biopsies and using animal models, the researchers hope to identify specific markers that could help in early detection and treatment of hypercholesterolemia associated with nephrotic syndrome.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or reducing high cholesterol levels in patients with nephrotic syndrome.
How similar studies have gone: Previous studies have shown promising results in understanding the role of PCSK9 in cholesterol regulation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Rush University Medical Center
Chicago, United States Active
Researchers
- Principal investigator: Clement, Lionel Claudius — Rush University Medical Center
- Study coordinator: Clement, Lionel Claudius
Related research
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Targeting calcineurin regulators for better diagnostics and treatments for nephrotic syndrome
This work looks at whether proteins that control calcineurin can be used to make better tests and more precise treatments for people with nephrotic syndrome.
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Investigating the role of a specific protein in childhood kidney disease
This study is looking at how a protein called CD93 might affect kidney health in children with Idiopathic Nephrotic Syndrome, and by examining blood and urine samples, researchers hope to find clues that could help doctors better understand and treat this condition.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.