Investigating the role of a specific protein in childhood kidney disease
Official title: Evidence For Endothelial Involvement in Idiopathic Nephrotic Syndrome: A Role for CD93
Funded at Research Inst Nationwide Children's Hosp · NIH-11120939 · Data updated 2026-11-12
This study is looking at how a protein called CD93 might affect kidney health in children with Idiopathic Nephrotic Syndrome, and by examining blood and urine samples, researchers hope to find clues that could help doctors better understand and treat this condition.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst Nationwide Children's Hosp NIH-funded |
| Lab location | 1 site (Columbus, United States) |
| Project start | July 1, 2024 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $153,651 |
| NIH project number | 5K08DK134761-02 |
| Project ID | NIH-11120939 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children diagnosed with Idiopathic Nephrotic Syndrome.
✕Less likely to help
Patients with nephrotic syndrome caused by known factors or other kidney diseases may not benefit from this research.
What this research studies
This research focuses on Idiopathic Nephrotic Syndrome (INS), a common kidney condition in children with an unknown cause. The study aims to understand how injury to the endothelial cells lining the kidney's capillaries may contribute to the disease. Researchers will investigate the role of a protein called CD93, which appears to be involved in the activation of these cells and may lead to kidney damage. By analyzing blood and urine samples from patients, the study seeks to identify biomarkers that could help predict disease progression and improve treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and targeted therapies for children suffering from Idiopathic Nephrotic Syndrome.
How similar studies have gone: Previous research has shown promising results in understanding the role of endothelial cells in kidney diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Research Inst Nationwide Children's Hosp
Columbus, United States Active
Researchers
- Principal investigator: Cara-Fuentes, Gabriel Miguel — Research Inst Nationwide Children's Hosp
- Study coordinator: Cara-Fuentes, Gabriel Miguel
Related research
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This work looks at whether proteins that control calcineurin can be used to make better tests and more precise treatments for people with nephrotic syndrome.
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Improving how we measure symptoms for nephrotic syndrome
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.