Noninvasive management of kidney disease in children
Ultrabright Plasmonic-Fluor Nanosensor-Enabled Noninvasive Management of Pediatric Nephrotic Syndrome
This study is testing a new, gentle way to check how well kidneys are working in kids with nephrotic syndrome, using tiny microneedles to take samples from the skin instead of drawing blood, making it easier and less stressful for them.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10593497 on NIH RePORTER |
What this research studies
This research focuses on developing a new, painless method to monitor kidney function in children suffering from nephrotic syndrome, a serious kidney disease. The approach utilizes advanced microneedle technology to extract bioanalytes from the skin without the need for blood draws, making it easier and less traumatic for young patients. By analyzing the interstitial fluid, the research aims to provide accurate and timely assessments of kidney health, which is crucial for effective treatment. This innovative method could significantly improve the quality of care for pediatric patients with this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years diagnosed with nephrotic syndrome, particularly those who are steroid-resistant.
Not a fit: Patients with nephrotic syndrome who are older than 11 years or those without a confirmed diagnosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a safer and more effective way to monitor kidney function in children, reducing the need for painful blood tests.
How similar studies have performed: Similar innovative approaches in noninvasive monitoring have shown promise in other medical fields, suggesting potential success for this novel method.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Chen, Ying Maggie — Washington University
- Study coordinator: Chen, Ying Maggie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.