Improving how we measure symptoms for nephrotic syndrome
Official title: Preparing a clinical outcomes assessment set for nephrotic syndrome [Prepare-NS]
Funded at University of Michigan at Ann Arbor · NIH-11082524 · Data updated 2026-11-12
This project aims to create better ways to measure how patients with nephrotic syndrome experience symptoms like fluid overload, making it easier to understand how new treatments are working.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | May 1, 2021 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $743,476 |
| NIH project number | 5UH3FD007308-05 |
| Project ID | NIH-11082524 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with nephrotic syndrome, particularly those experiencing fluid overload, may be ideal candidates for providing input on their experiences and symptoms.
✕Less likely to help
Patients who do not have nephrotic syndrome or are not experiencing fluid overload would likely not directly benefit from this specific research.
What this research studies
We are working to develop and test a core set of tools to measure important symptoms for people with nephrotic syndrome, especially focusing on fluid overload. This involves gathering insights from patients, doctors, regulators, and drug developers to make sure these tools truly reflect what matters most to patients. Our goal is to create reliable and patient-focused ways to track symptoms, which will help in the development of new medicines. Once developed, these new measurement tools will be made widely available for use in future clinical trials.
Why it matters
Potential benefit: If successful, this work could lead to more accurate and patient-centered ways to measure treatment effectiveness for nephrotic syndrome, potentially speeding up the development of new therapies.
How similar studies have gone: While the development of clinical outcome assessments is an established field, this specific effort to create a core set for nephrotic syndrome with a focus on fluid overload is a novel and comprehensive approach.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Salmon, Eloise — University of Michigan at Ann Arbor
- Study coordinator: Salmon, Eloise
Related research
Other NIH-funded projects on the same topics.
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Whole genome sequencing to uncover molecular causes in nephrotic syndrome
A study to map the genetic and molecular factors behind nephrotic syndrome and related kidney diseases to help diagnose and guide future treatments for patients.
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Sodium-related edema in nephrotic syndrome and ANGPTL4
A physician-scientist group is studying how a protein called ANGPTL4 may drive skin edema in nephrotic syndrome, with experiments in rodents and tests on human ANGPTL4 fragments.
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Immune-driven tubulointerstitial injury in pediatric nephrotic syndrome
A physician-scientist aims to understand how immune processes cause kidney tissue damage in children with difficult-to-treat nephrotic syndrome.
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Hodgkin lymphoma–linked nephrotic syndrome and kidney injury
This project looks at how Hodgkin lymphoma may cause nephrotic syndrome by changing a kidney gene and exposing kidney cells to lymphoma-related substances.
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Targeting calcineurin regulators for better diagnostics and treatments for nephrotic syndrome
This work looks at whether proteins that control calcineurin can be used to make better tests and more precise treatments for people with nephrotic syndrome.
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Investigating the role of a specific protein in childhood kidney disease
This study is looking at how a protein called CD93 might affect kidney health in children with Idiopathic Nephrotic Syndrome, and by examining blood and urine samples, researchers hope to find clues that could help doctors better understand and treat this condition.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.