Longitudinal study of childhood nephrotic syndrome
INSIGHT (Insight Into Nephrotic Syndrome: Investigating Genes, Health and Therapeutics)
The Hospital for Sick Children · NCT01605266
This study looks at children with nephrotic syndrome to see how genetics, blood tests, and environmental factors affect the condition and its progression over time.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1000 (estimated) |
| Ages | 6 Months to 18 Years |
| Sex | All |
| Sponsor | The Hospital for Sick Children (other) |
| Locations | 4 sites (Brampton, Ontario and 3 other locations) |
| Trial ID | NCT01605266 on ClinicalTrials.gov |
What this trial studies
INSIGHT is a longitudinal observational study focused on childhood nephrotic syndrome, aiming to identify genetic, serologic, and environmental factors that contribute to the condition and its progression. The study involves a large multiethnic cohort and recruits participants from Toronto and surrounding regions, with plans to expand to additional sites in the future. By collecting data over time, the study seeks to test hypotheses regarding risk factors and disease outcomes in affected children.
Who should consider this trial
Good fit: Ideal candidates for this study are children aged 6 months to 18 years diagnosed with nephrotic syndrome.
Not a fit: Patients with congenital nephrotic syndrome or syndromic diseases involving multiple organ systems may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of nephrotic syndrome in children.
How similar studies have performed: Other studies have explored genetic and environmental factors in nephrotic syndrome, but this specific longitudinal approach is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. diagnosis of nephrotic syndrome 2. signed informed consent and assent appropriate for age 3. ages 6 months -18 years old and 4. ability to complete questionnaires Exclusion Criteria: 1. congenital nephrotic syndrome (less than age 1) 2. syndromic disease with multiple organ involvement 3. inability to provide consent by primary care providers 4. conditions such as systemic lupus erythematous.
Where this trial is running
Brampton, Ontario and 3 other locations
- William Osler Health System, Brampton Civic Hospital and Peel Memorial Centre for Integrated Health and Wellness — Brampton, Ontario, Canada (RECRUITING)
- Hamilton Health Sciences Corporation - McMaster University Medical Centre — Hamilton, Ontario, Canada (RECRUITING)
- Rouge Valley Health System, Rouge Valley Centenary — Scarborough Village, Ontario, Canada (RECRUITING)
- The Hospital for Sick Children — Toronto, Ontario, Canada (RECRUITING)
Study contacts
- Principal investigator: Rulan Parekh, MD — The Hospital for Sick Children
- Study coordinator: Rulan Parekh, MD
- Email: rulan.parekh@sickkids.ca
- Phone: 416-813-7654
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Nephrotic Syndrome, pediatric, kidney disease, minimal change disease, focal segmental glomerulosclerosis, nephrotic syndrome