Investigating how calcineurin pathways can help diagnose and treat nephrotic syndrome
REGULATORS OF CALCINEURIN PATHWAYS AS DIAGNOSTIC AND THERAPEUTIC TARGETS FOR NEPHROTIC SYNDROME
['FUNDING_R01'] · DUKE UNIVERSITY · NIH-11013317
This study is looking into the genetic factors that cause nephrotic syndrome and other kidney diseases to find easier ways to diagnose and treat these conditions, helping patients feel better and manage their health more effectively.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-11013317 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the molecular mechanisms behind nephrotic syndrome (NS) and other glomerular diseases, which are significant contributors to chronic kidney disease. By studying specific genetic variants related to calcineurin regulators, the research aims to identify non-invasive diagnostic tools and effective treatment options. The approach includes examining how mutations in these genes affect cell behavior and exploring potential pharmacological interventions to mitigate harmful effects. This could lead to targeted therapies for patients suffering from NS and improve overall patient care.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with nephrotic syndrome, particularly those with steroid-resistant forms of the disease.
Not a fit: Patients with nephrotic syndrome caused by factors unrelated to calcineurin pathways may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and targeted therapies for patients with nephrotic syndrome.
How similar studies have performed: Previous research has shown promise in targeting calcineurin pathways for treating kidney diseases, indicating that this approach may yield beneficial results.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GBADEGESIN, RASHEED ADEBAYO — DUKE UNIVERSITY
- Study coordinator: GBADEGESIN, RASHEED ADEBAYO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.