Investigating how calcineurin pathways can help diagnose and treat nephrotic syndrome
Official title: REGULATORS OF CALCINEURIN PATHWAYS AS DIAGNOSTIC AND THERAPEUTIC TARGETS FOR NEPHROTIC SYNDROME
Funded at Duke University · NIH-11013317 · Data updated 2026-11-12
This study is looking into the genetic factors that cause nephrotic syndrome and other kidney diseases to find easier ways to diagnose and treat these conditions, helping patients feel better and manage their health more effectively.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | February 1, 2023 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $598,348 |
| NIH project number | 5R01DK134347-03 |
| Project ID | NIH-11013317 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with nephrotic syndrome, particularly those with steroid-resistant forms of the disease.
✕Less likely to help
Patients with nephrotic syndrome caused by factors unrelated to calcineurin pathways may not benefit from this research.
What this research studies
This research focuses on understanding the molecular mechanisms behind nephrotic syndrome (NS) and other glomerular diseases, which are significant contributors to chronic kidney disease. By studying specific genetic variants related to calcineurin regulators, the research aims to identify non-invasive diagnostic tools and effective treatment options. The approach includes examining how mutations in these genes affect cell behavior and exploring potential pharmacological interventions to mitigate harmful effects. This could lead to targeted therapies for patients suffering from NS and improve overall patient care.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and targeted therapies for patients with nephrotic syndrome.
How similar studies have gone: Previous research has shown promise in targeting calcineurin pathways for treating kidney diseases, indicating that this approach may yield beneficial results.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Gbadegesin, Rasheed Adebayo — Duke University
- Study coordinator: Gbadegesin, Rasheed Adebayo
Related research
Other NIH-funded projects on the same topics.
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Whole genome sequencing to uncover molecular causes in nephrotic syndrome
A study to map the genetic and molecular factors behind nephrotic syndrome and related kidney diseases to help diagnose and guide future treatments for patients.
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Sodium-related edema in nephrotic syndrome and ANGPTL4
A physician-scientist group is studying how a protein called ANGPTL4 may drive skin edema in nephrotic syndrome, with experiments in rodents and tests on human ANGPTL4 fragments.
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Immune-driven tubulointerstitial injury in pediatric nephrotic syndrome
A physician-scientist aims to understand how immune processes cause kidney tissue damage in children with difficult-to-treat nephrotic syndrome.
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Hodgkin lymphoma–linked nephrotic syndrome and kidney injury
This project looks at how Hodgkin lymphoma may cause nephrotic syndrome by changing a kidney gene and exposing kidney cells to lymphoma-related substances.
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Targeting calcineurin regulators for better diagnostics and treatments for nephrotic syndrome
This work looks at whether proteins that control calcineurin can be used to make better tests and more precise treatments for people with nephrotic syndrome.
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Investigating the role of a specific protein in childhood kidney disease
This study is looking at how a protein called CD93 might affect kidney health in children with Idiopathic Nephrotic Syndrome, and by examining blood and urine samples, researchers hope to find clues that could help doctors better understand and treat this condition.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.