Understanding genetic risks in kidney disease and transplant outcomes
Defining the Landscape of HLA Risk Alleles in Primary Nephrotic Syndrome and Post Kidney Transplant Recurrence
['FUNDING_U01'] · DUKE UNIVERSITY · NIH-10848358
This study is looking at how certain genes, especially those related to the immune system, might affect people with primary nephrotic syndrome and how they respond to treatments like kidney transplants, so we can better understand the condition and improve care for patients.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-10848358 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic factors associated with primary nephrotic syndrome, particularly focusing on the role of Human Leukocyte Antigen (HLA) genes. By analyzing a diverse group of over 3,700 patients, the study aims to identify specific genetic variants that may influence the disease's progression and response to treatments, including kidney transplants. Using advanced next-generation sequencing techniques, the researchers will explore both coding and non-coding regions of HLA genes to gain insights into how these genetic factors contribute to the risk of nephrotic syndrome and its recurrence after transplantation.
Who could benefit from this research
Good fit: Ideal candidates for this research include children and young adults diagnosed with primary nephrotic syndrome, especially those who are steroid resistant or have undergone kidney transplantation.
Not a fit: Patients with nephrotic syndrome who are steroid sensitive and do not require transplantation may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for predicting and managing nephrotic syndrome and its recurrence in kidney transplant patients.
How similar studies have performed: Previous studies have shown associations between HLA variants and nephrotic syndrome, but this research aims to expand on those findings with a larger, more diverse patient population and advanced sequencing techniques.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GBADEGESIN, RASHEED ADEBAYO — DUKE UNIVERSITY
- Study coordinator: GBADEGESIN, RASHEED ADEBAYO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.