Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Online yoga versus Acceptance and Commitment Therapy for chronic musculoskeletal pain in veterans

Official title: Online Yoga vs Acceptance and Commitment Therapy for Treating Chronic Musculoskeletal Pain

Run by Palo Alto Veterans Institute for Research · NCT06704061 · Data updated 2026-11-12

This project will test whether online yoga works as well as Acceptance and Commitment Therapy to reduce chronic musculoskeletal pain in veterans.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment274 (estimated)
SponsorPalo Alto Veterans Institute for Research
Academic / other
Locations1 site (Palo Alto, California)
StatusRecruiting
StartedJanuary 7, 2026
Main results expectedNovember 1, 2029
Study endsNovember 1, 2029
Registry record updatedJanuary 29, 2026
Trial IDNCT06704061 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are U.S. veterans aged 18 or older with at least six months of musculoskeletal pain, a moderate baseline pain score (≥4), stable pain medications, English literacy, and reliable home internet access.

Probably not a fit

Patients with very low or very high baseline pain scores, recent back surgery, a specific structural cause of back pain, unstable medical or psychiatric conditions, current regular yoga practice, or active suicidal intent are unlikely to qualify or benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized trial will assign veterans with chronic musculoskeletal pain to either weekly online yoga classes or weekly online group Acceptance and Commitment Therapy (ACT) sessions for 12 weeks. Participants will complete self-report questionnaires about pain and function at baseline, during treatment, and over a six-month follow-up. The primary analysis is a non-inferiority comparison to see if online yoga produces pain outcomes comparable to ACT. The team will monitor adverse events and keep regular contact to capture safety and the durability of any benefits.

Why it matters

Potential benefit: If successful, online yoga could provide a low-cost, accessible non-drug option to reduce chronic musculoskeletal pain for veterans.

How similar studies have gone: ACT is an established, evidence-based treatment for chronic pain and prior research shows yoga can help chronic pain, but direct non-inferiority comparisons of online yoga versus ACT are limited.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Veteran of the United States Armed Forces ≥ 18 years old
* Chronic pain \> 6 months related to at least one musculoskeletal pain-related diagnosis indicated by an ICD-9 or -10 code
* Minimum pain intensity at screening ≥4 on a 0-10 using the Defense and Veterans Pain Rating Scale (DVPRS)
* Not begun new pain treatments or medications in the past month
* Stable medication regimen for at least 4 weeks prior to entry to the study
* English literacy
* Internet connection at home

Exclusion Criteria:

* Participation in another clinical trial, unless given prior authorization from both our research team and that of the other study
* Back surgery within the last 12 months
* Back pain potentially attributed to a specific known condition
* Baseline pain \<4 or ≥9 on a 0-10 Numeric Rating Scale
* Unstable, serious coexisting medical illness, mental illness or psychiatric conditions
* Attended or practiced yoga ≥ 1 x in the past 12 months
* Current suicidal intent or plan
* Has received ACT in the past

Where it's running

  • Palo Alto VA Medical Center
    Palo Alto, California, United States
    Recruiting

Study contacts

  • Principal investigator: Peter Bayley, PhD — Palo Alto Veterans Institute for Research
  • Study coordinator: Peter Bayley, PhD
  • Email: peter.bayley@va.gov
  • Phone: 650-493-5000

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.